Harvard Office of Technology Development

Red Blood Cell-Hitchhiking for Targeted Drug Delivery

Drug delivery utilizing nanocarriers (NCs) as a targeted approach has been actively pursued; however, even with the use of different affinity moieties such as antibodies to improve targeting and reduce off-target toxicity, NCs are predominately…

Investigators

Samir Mitragotri

Novel Biochemical and Computational Approaches to Increase Mass Spectrometry Sensitivity

Mass spectrometry (MS) has become the leading protein identification technique. Current mass spectrometry methods rely on tandem MS/MS detection, where a prepared peptide digestion sample is injected into the mass spectrometer and analyzed by its…

Investigators

Marc Kirschner
Mingjie Dai

New Raman Microscopy Technique Accelerates Digital Pathology

Current methods for pathological diagnosis of diseases require laborious and costly sample processing steps and provide inherently qualitative information. Moreover, batch to batch variations in staining intensity results in highly variable images,…

Investigators

Marc Kirschner
Seungeun Oh

DNA Destruction Through Novel and Adaptable Enzymes

Bacteria in mixed populations compete for resources and have several strategies on surviving and dominating other bacterial species. One method employs the injection of lethal effectors into adjacent cells. These effectors can disrupt cell membranes…

Investigators

Karine Gibbs

Inhibiting Microbial Metabolism of Levodopa to Increase Availability in the CNS

Parkinson’s disease (PD) impacts 10 million people globally, with 60,000 Americans newly diagnosed every year. Levodopa remains the gold standard treatment for PD, despite limitations including side effects and peripheral metabolism. Current…

Investigators

Emily Balskus

Reproducible Individual Brain Organoids

The human brain is a highly complex organ comprised of a variety of cell types and that are largely generated during embryonic development. While this process is invariable in vivo, it is unclear if this can be recapitulated outside of the embryo.…

Investigators

Paola Arlotta

Cyborg organoids with fully integrated nanoelectronics

Researchers from the Liu lab at Harvard have grown organoids with fully integrated sensors that grow with the developing cells, giving them the unique ability to study the early stages of organ development. Organoids are 3D clusters of cells that…

Investigators

Jia Liu
Kewang Nan
Qiang Li

Scalable method for manufacture of thin film photovoltaic devices

Photovoltaic devices based on perovskites hold the potential of thin, light structures and very high efficiencies. However, the instability of perovskites in air leads to very short device lifetimes (on the order of hours), and thus silicone-based…

Investigators

Roy Gordon
Christina Chang
Luke Davis

Hardware Accelerators for Machine Learning Systems

Conventional computing platforms are inefficient at handling complex machine learning algorithms, which has limited the use of artificial intelligence (AI) in business applications. With support from Harvard's Physical Sciences & Engineering…

Investigators

David Brooks
Gu-Yeon Wei

Disinfecting Pathogens on Surfaces and in Air

Pathogens found in the air and on surfaces present a massive global health challenge, threating human health and food security. The lab of Philip Demokritou at Harvard’s T.H. Chan School of Public Health has developed Engineered Water Nanostructures…

Investigators

Philip Demokritou