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Attivare, a startup advancing a portfolio of technologies developed at the Wyss Institute, John A. Paulson School of Engineering and Applied Sciences, Dana-Farber Cancer Institute, and Massachusetts General Hospital, has shown promising results in cancer clinical trials and is developing a malaria vaccine. Through decades of innovation and cross-disciplinary collaboration, the technology has the potential to fight cancer more effectively or prevent pathogen-related infections. 

For more than three decades, Greg Verdine has brought bold, innovative methods to solving some of medicine’s biggest challenges - from early-stage work backed by the Harvard Blavatnik Biomedical Accelerator to the launch of multiple startups.

A Harvard-led team synthesized 64 distinct DNA sequences on a silicon chip in parallel – not by using the solvent-heavy chemistry that dominates custom DNA manufacturing today, but through a water-based enzymatic process. The research was led by Donhee Ham, the John A. and Elizabeth S. Armstrong Professor of Engineering and Applied Sciences at the John A. Paulson School of Engineering and Applied Sciences.

Researchers at the Harvard John A. Paulson School of Engineering and Applied Sciences built a device called a pico-calorimeter that directly measures heat signals from small groups of living cells. The device could lead to advances in bacterial growth monitoring or antibiotic resistance testing.