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Displaying: 71 - 80 of 139 Results
Shh Knock Out Mice
Mice homozygous for the Shhtm1Amc targeted mutation display early defects in the establishment and maintenance of midline structures. These defects result from the critical role the Sonic hedgehog (Shh) gene plays in the patterning of vertebrate…
DBD
- Vivian Berlin
Investigators
- Andrew McMahon
Shh Targeted Mutation Mice
Mice that are homozygous for the Shhtm2Amc targeted mutation are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. This conditional mutant contains two loxP sites flanking exon 2 of the targeted…
DBD
- Vivian Berlin
Investigators
- Andrew McMahon
Shh::gfp Targeted Mutation Mice
While mice heterozygous for the Shh::gfp allele are viable, fertile, and indistinguishable from wild-type littermates, homozygotes are stillborn and show developmental defects consistent with reduced Sonic Hedgehog (Shh) signaling. The Shh::gfp…
DBD
- Vivian Berlin
Investigators
- Andrew McMahon
Six2-GCE Targeted Mutation Mice
While heterozygous mice are viable and fertile with no reported abnormalities, homozygous mice die shortly after birth. The Six2GCE "knock-in" allele both abolishes Six2 gene function and expresses an eGFPCreERT2 fusion protein (EGFP and creERT2…
DBD
- Vivian Berlin
Investigators
- Andrew McMahon
Six2-TGCtg EFGPCre Transgenic Mice
Six2-TGCtg mice harbor an ~181 kb BAC transgene with a Tet-off-eGFPCre under control of the Six2 promoter/enhancer regions within the BAC transgene. The Tet-off-eGFPCre contains both the tetracycline-controlled transactivator protein (tTA) as well…
DBD
- Vivian Berlin
Investigators
- Andrew McMahon
Smo Knock Out Mice
Mice that are heterozygous for the targeted allele are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. Homozygous null mice have an embryonic lethal phenotype, failing to develop past 9.5 days post…
DBD
- Vivian Berlin
Investigators
- Andrew McMahon
Sox2Cre Transgenic Mice
These transgenic mice express Cre recombinase under the control of the mouse SRY-box containing gene 2 promoter. The transgene integrated into an intron of Edil3 (EGF-like repeats and discoidin I-like domains 3). The insertion results in a…
DBD
- Vivian Berlin
Investigators
- Andrew McMahon
Sox2-cre Transgenic Mice
The Sox2Cre transgene was designed with 12.5 kb of upstream regulatory sequence from the mouse Sox2 locus (SRY-box containing gene 2), a chicken _-actin intron, a Cre recombinase gene, and a rabbit _-globin poly(A) sequence. This transgene was…
DBD
- Vivian Berlin
Investigators
- Andrew McMahon
spH Trangenic Mice
These transgenic mice express spH, the pH-sensitive variant of the green fluorescent protein (superecliptic pHluorin) fused to the mouse synaptic vesicle-associated membrane protein 2 (Vamp2), under the control of the mouse thymus cell antigen 1…
DBD
- Yelena Bisharyan
Investigators
- Venkatesh Murthy
spH64 Thy1 Transgenic Mice
These transgenic mice express spH, the pH-sensitive variant of the enhanced green fluorescent protein (ecliptic pHluorin) fused to the mouse synaptic vesicle-associated membrane protein 2 (Vamp2), under the control of the mouse thymus cell antigen 1…
DBD
- Yelena Bisharyan
Investigators
- Venkatesh Murthy