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KRT14-cre Transgenic Mice
Mice hemizygous for the K14-Cre transgene are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. These transgenic mice express Cre recombinase under the control of the human keratin 14 promoter. Cre…
DBD
- Vivian Berlin
Investigators
- Andrew McMahon
L7Cre Transgenic Mice
Hemizygous mice are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities. Cre activity is observed in parasagittal domains of the cerebellum beginning at embryonic day 17 (E17). At E19, low level…
DBD
- Vivian Berlin
Investigators
- Andrew McMahon
Lfng-nuc-Tag-RFP-T-IRES-CE Transgenic Mice
These Lfng-nuc-Tag-RFP-T-IRES-CE mutant mice have a tamoxifen inducible Cre-mediated recombination system and express the Tag-RFPT variant of Red Fluorescent Protein under the direction of the mouse Lfng, LFNG O-fucosylpeptide…
DBD
- Vivian Berlin
Investigators
- Andrew McMahon
Meox1-nucTagRFP-T-IRES-CE Transgenic Mice
These Meox1-nucTagRFP-T-IRES-CE mutant mice have a tamoxifen inducible Cre-mediated recombination system and express the nuclear-localized Tag-RFPT variant of Red Fluorescent Protein under the direction of the mouse Meox1, mesenchyme homeobox 1,…
DBD
- Vivian Berlin
Investigators
- Andrew McMahon
Mif Knock Out Mice
These mice have a neo cassette disrupting exons 2-3 of the macrophage migration inhibitory factor (glycosylation-inhibiting factor) (MIf) gene, abolishing gene expression. MIF is a lymphokine involved in cell-mediated immunity, immunoregulation, and…
DBD
- Yelena Bisharyan
Investigators
- John David
Ngn1-CreERT2 Transgenic Mice
These transgenic mice have a tamoxifen inducible Cre-mediated recombination system driven by the mouse neurogenin 1, Neurog1, promoter. The transgene insert contains a fusion product involving Cre recombinase and a mutant form of the mouse estrogen…
DBD
- Irit Ben-Chelouche
Investigators
- Lisa Goodrich
Ngn3/CreER Trangenic Mice
These transgenic mice have a tamoxifen inducible Cre-mediated recombination system driven by the mouse neurogenin 3, Neurog3, promoter. The transgene insert contains a fusion product involving Cre recombinase and a mutant form of the mouse estrogen…
DBD
- Vivian Berlin
Investigators
- Douglas Melton
NOD.DQ6, H2-Ab0null,Rag1null
Rag1 and H2-Ab1 deficient NOD mice carrying transgenes encoding humanized CD4 and HLA-DQ6 lack T and B cells and are free of autoimmune diabetes and cardiomyopathy, and do not develop thyroiditis. This model is useful in adoptive transfer…
DBD
- Irit Ben-Chelouche
Investigators
- Michael Grusby
NOD.DQ8, H2-Ab0null Mice
The NOD transgenic HLA DQ8, H2-Ab1deficient mouse is diabetes resistant but develops cardiomyopathy resulting in early death from heart failure in both males and females. Histological exam indicates hearts are 3-4x larger than wildtype. Pathology…
DBD
- Irit Ben-Chelouche
Investigators
- Michael Grusby
NOD.DQ8, H2-Ab0null,Rag1null Mice
Rag1 and H2-Ab1 deficient NOD mice carrying transgenes coding for human CD2-CD4 and HLA-DQ8 lack T and B cells, and are diabetes free. Also, unlike the H2-Ab1 deficient, transgenic CD4, HLA-DQ8 mice (see Stock No. 006021), this strain does not…
DBD
- Irit Ben-Chelouche
Investigators
- Michael Grusby