DBD Search
Vivian Berlin
Executive Director, HMS
Displaying: 41 - 50 of 75 Results
Research Tool
Wnt5 Knock Out Mice
Homozygous null mice have a perinatal lethal phenotype and do not survive long after birth due to respiratory failure. Mice that are heterozygous for the targeted mutation are viable, fertile, normal in size and do not display any gross physical or…
Investigators
- Andrew P. McMahon
Research Tool
RosaGli1Flag c/c Transgenic Mice
These RosaGli1Flag c/c mice contain a floxed-neomycin resistance (neo) cassette and polyadenylation signal, cDNA encoding a FLAG-tagged GLI-Kruppel family member (Gli1) gene, an internal ribosome entry site (IRES), and a Venus yellow fluorescent…
Investigators
- Andrew P. McMahon
Research Tool
Disp1_2C Transgenic Mice
These mice possess loxP sites on either side of exon 2 of the targeted gene. Mice that are homozygous for this allele are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. When used in conjunction…
Investigators
- Andrew P. McMahon
Research Tool
Upk3a-GCE Transgenic Mice
These transgenic mice express the eGFPCreERT2 (Enhanced Green Fluorescent Protein and cre/ESR1) fusion gene under the direction of the mouse Upk3a, uroplakin 3A, promoter. Transgene expression is detected in the bladder urothelium and ureters of…
Investigators
- Andrew P. McMahon
Research Tool
Noggin Knock Out Mice
Homozygous mice are born but die shortly after birth, exhibiting multiple defects, including an open neural tube, skeletal abnormalities, shortened body axis, and a small vestigial tail. Analysis of early gene expression has shown that the loss of…
Investigators
- Andrew P. McMahon
Research Tool
Uba6flox/flox Targeted Mutation Mice
These Uba6flox/flox mutant mice possess loxP sites flanking exons 16-17 of the ubiquitin-like modifier activating enzyme 6 (Uba6) gene. Uba6 (E1) is part of the ubiquitin proteasome system (UPS) which regulates protein homeostasis during…
Research Tool
Akr1b7RFP Trangenic Mice
These transgenic mice express Red Fluorescent Protein (TagRFP-T variant) under the direction of the mouse Akr1b7, aldo-keto reductase family 1, member B7, promoter. Transgene expression is detected at high levels in the adrenal glands and…
Investigators
- Andrew P. McMahon
Research Tool
Six2-TGCtg EFGPCre Transgenic Mice
Six2-TGCtg mice harbor an ~181 kb BAC transgene with a Tet-off-eGFPCre under control of the Six2 promoter/enhancer regions within the BAC transgene. The Tet-off-eGFPCre contains both the tetracycline-controlled transactivator protein (tTA) as well…
Investigators
- Andrew P. McMahon
Research Tool
Irf8 Knock Out Mice
Mice homozygous for this Irf8 knockout allele (Irf8-/-) may be expected to to exhibit some or all of the phenotype published for other Irf8 null mutations on both a C57BL/6J-congenic and mixed genetic background. For example, other Ifr8 null mice…
Investigators
- Andrew P. McMahon
Research Tool
Wnt7a Knock Out Mice
Mice that are homozygous for the targeted mutation are viable, but sterile. A truncated mRNA transcript is detected during embryogenesis. Homozygotes exhibit ventralization of dorsal limb mesoderm tissues. The variable phenotype includes thickening…
Investigators
- Andrew P. McMahon