DBD Search
Grant R. Zimmermann
Managing Director of Business Development, Blavatnik Biomedical Accelerator
Displaying: 41 - 50 of 67 Results
Invention
Phaeobacticides - Potent and selective new class of algae growth inhibitors
Algae are a diverse group of uni- and multicellular plants that grow in water. Undesired and uncontrolled algal blooms are a recurring problem in bodies of water such as swimming pools, aquaculture ponds, aquariums, industrial drainage systems and…
Investigators
- Jon Clardy
- Roberto G. Kolter
- Mohammad R. Seyedsayamdost
- Rebecca J. Case
Invention
HEK293T cells stably express Divalent Metal Transporter-1 for use in a model system to screen for inhibitors of iron uptake
This invention is a cell-based screen that enables the rapid identification of iron transport inhibitors. From initial efforts, 10 small molecule inhibitors of transport have been identified, and ongoing studies focus on characterizing their…
Investigators
- Marianne Wessling-Resnick
- Peter Buckett
Invention
Targeted inhibition of the SREBP-mediator interaction as a novel therapeutic
While most therapeutic approaches aimed at altering gene expression programs target upstream signaling pathways or nuclear translocation checkpoints, Scientists at the Wagner lab have provided mechanistic insights supporting an alternative approach,…
Investigators
- Gerhard Wagner
- Anders M. Naar
- Haribabu Arthanari
Invention
Migration inhibitory factor (MIF) knockout mouse
To study the biological role of migration inhibitory factor (MIF), a pleiotropic cytokine, we generated a mouse strain lacking MIF by gene targeting in embryonic stem cells. Analysis of the role of MIF during sepsis showed that MIF-/- mice were…
Investigators
- John R. David
- Marcelo Torres Bozza
- Craig Gerard
Invention
Mass spectrometry-based in vitro kinome activity assay
This technology is a new generation, high-throughput assay to quantitatively assess the activity of the kinome in a variety of samples. Cocktails of synthetic peptides are combined with a sample of interest and phosphorylated by kinases in the…
Investigators
- Steven P. Gygi
- Judit Villen
- Kazuishi Kubota
- Yong Yu
Invention
Inhibitors of protein-processivity factor
Harvard investigators have discovered that Pol interacts with a processivity factor at a site that is distinct from sites of normal interaction between known Pol family members and other cellular factors. Unlike most protein-protein interactions,…
Investigators
- Donald M. Coen
- James M. Hogle
- Harmon Zuccola
- Kristie Grove Bridges
- Carl Elkin
- Scott R. Lokey
Invention
A fusion intermediate state of HIV-1 gp41, targeted by broadly neutralizing antibodies, for purposes of vaccination
HIV infection generally induces a strong antibody response to the envelope glycoprotein, the sole antigen on the virion surface. Most of the induced antibodies are ineffective in preventing infection, however, as they are either non-neutralizing or…
Investigators
- Stephen C. Harrison
- Gary H. Frey
- Bing Chen
Invention
Method for producing site-specific recombination of DNA in a transgenic non-human mammal at chromosomal regions containing Flp-recognition sites
A method is disclosed for producing site-specific recombination of DNA in a transgenic non-human mammal at chromosomal regions containing Flp-recognition sites (e.g., a DNA sequence containing an FRT site). The invention in particular discloses the…
Investigators
- Susan M. Dymecki
- A. Francis Stewart
Research Tool
Crx GFPAP Transgenic Mice
Hemizygotes are viable and fertile. Expression of human placental alkaline phosphatase (PLAP) and GFP recapitulates that of the endogenous Crx promoter in the retina at embryonic time points as early as embryonic day 12.5 (E12.5) and in the retina…
Investigators
- Connie Cepko
Research Tool
casp-11 Knock Out Mice
Caspase 4 (also known as caspase 11) is a critical upstream regulator in the caspase cascade with an important dual role in regulating both inflammatory response and apoptosis. Splenocytes harvested from homozygous mice both before and after…
Investigators
- Junying Yuan