DBD Search

Invention

Knockout mouse model for human liver cancer

While most hepatocytes in healthy liver are resting cells, deletion of Mad2 in liver activates the cell cycles and causes proliferation of hepatocytes. Cre-mediated, simultaneous liver-specific knockout of Mad2 and p53 induces mouse cancer which…

Invention

Monoclonal IgE anti-ovalbumin antibody

A laboratory from the Harvard School of Public Health has developed a monoclonal Ig E mouse anti-ovalbumin. This antibody is useful as a positive control in ELISA assays used to measure the level of IgE anti-ovalbumin antibodies in mouse models of…

Invention

Phaeobacticides - Potent and selective new class of algae growth inhibitors

Algae are a diverse group of uni- and multicellular plants that grow in water. Undesired and uncontrolled algal blooms are a recurring problem in bodies of water such as swimming pools, aquaculture ponds, aquariums, industrial drainage systems and…

Invention

Targeted inhibition of the SREBP-mediator interaction as a novel therapeutic

While most therapeutic approaches aimed at altering gene expression programs target upstream signaling pathways or nuclear translocation checkpoints, Scientists at the Wagner lab have provided mechanistic insights supporting an alternative approach,…

Invention

Disease incidence/prevalence analytical model

Invention

HEK293T cells stably express Divalent Metal Transporter-1 for use in a model system to screen for inhibitors of iron uptake

This invention is a cell-based screen that enables the rapid identification of iron transport inhibitors. From initial efforts, 10 small molecule inhibitors of transport have been identified, and ongoing studies focus on characterizing their…

Invention

Migration inhibitory factor (MIF) knockout mouse

To study the biological role of migration inhibitory factor (MIF), a pleiotropic cytokine, we generated a mouse strain lacking MIF by gene targeting in embryonic stem cells. Analysis of the role of MIF during sepsis showed that MIF-/- mice were…

Invention

Mass spectrometry-based in vitro kinome activity assay

This technology is a new generation, high-throughput assay to quantitatively assess the activity of the kinome in a variety of samples. Cocktails of synthetic peptides are combined with a sample of interest and phosphorylated by kinases in the…

Research Tool

ROSA26::FLPe Knock In Mice

Homozygous FLPeR mice are viable and fertile, with widespread expression of the FLPe variant of the Saccharomyces cerevisiae FLP1 recombinase gene driven by the Gt(ROSA)26Sor promoter. The FLPe recombinase variant exhibits enhanced thermostability…