Grant R. Zimmermann

Managing Director of Business Development, Blavatnik Biomedical Accelerator

Displaying: 31 - 40 of 46 Results

Inhibitors of protein-processivity factor

Harvard investigators have discovered that Pol interacts with a processivity factor at a site that is distinct from sites of normal interaction between known Pol family members and other cellular factors. Unlike most protein-protein interactions,…


  • Donald M. Coen
  • James M. Hogle
  • Harmon Zuccola
  • Kristie Grove Bridges
  • Carl Elkin
  • Scott R. Lokey

Phaeobacticides - Potent and selective new class of algae growth inhibitors

Algae are a diverse group of uni- and multicellular plants that grow in water. Undesired and uncontrolled algal blooms are a recurring problem in bodies of water such as swimming pools, aquaculture ponds, aquariums, industrial drainage systems and…


  • Jon Clardy
  • Roberto G. Kolter
  • Mohammad R. Seyedsayamdost
  • Rebecca J. Case

Method for producing site-specific recombination of DNA in a transgenic non-human mammal at chromosomal regions containing Flp-recognition sites

A method is disclosed for producing site-specific recombination of DNA in a transgenic non-human mammal at chromosomal regions containing Flp-recognition sites (e.g., a DNA sequence containing an FRT site). The invention in particular discloses the…


  • Susan M. Dymecki
  • A. Francis Stewart

SpeedGene: A compression algorithm for fast and efficient storage of next-generation genetic sequencing studies

To solve the problem of large file sizes and long loading times of pedigree files for GWAS studies and next-generation sequencing studies, researchers at the Harvard School of Public Health have developed a new compression algorithm -- SpeedGene –…


  • Christoph Lange
  • Dandi Qiao

Anti-PLK-1 monoclonal antibody

The monoclonal antibody PLK-1 recognizes the Macrophage Receptor with Collagenous structure (MARCO). The scavenger receptors (SRs) expressed by macrophages are thought to play an important role in the immune response against bacteria by mediating…


  • Lester Kobzik
  • Aiyappa M. Palecanda

Targeted inhibition of the SREBP-mediator interaction as a novel therapeutic

While most therapeutic approaches aimed at altering gene expression programs target upstream signaling pathways or nuclear translocation checkpoints, Scientists at the Wagner lab have provided mechanistic insights supporting an alternative approach,…


  • Gerhard Wagner
  • Anders M. Naar
  • Haribabu Arthanari

Absolute quantification of Proteins (AQUA)

This invention provides methods, reagents and kits for obtaining absolute quantification of proteins and their modifications directly from cell lysates. In particular, the invention provides peptide internal standards for use in high performance…


  • Steven P. Gygi
  • Scott A. Gerber

Monoclonal IgE anti-ovalbumin antibody

A laboratory from the Harvard School of Public Health has developed a monoclonal Ig E mouse anti-ovalbumin. This antibody is useful as a positive control in ELISA assays used to measure the level of IgE anti-ovalbumin antibodies in mouse models of…


  • Lester Kobzik
  • Aiyappa M. Palecanda

HEK293T cells stably express Divalent Metal Transporter-1 for use in a model system to screen for inhibitors of iron uptake

This invention is a cell-based screen that enables the rapid identification of iron transport inhibitors. From initial efforts, 10 small molecule inhibitors of transport have been identified, and ongoing studies focus on characterizing their…


  • Marianne Wessling-Resnick
  • Peter Buckett

Homozygous IKKepsilon knockout mouse as an animal model for influenza virus infection

Homozygous IKKepsilon (inhibitor of kappaB kinase epsilon) mutant mice are used as animal models for influenza virus infection. Homozygous deletion results in a complete loss of the endogenous kinase function in lung, spleen, and embryonic…


  • Thomas Maniatis
  • Benjamin R. tenOever

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