Grant R. Zimmermann

Managing Director of Business Development, Blavatnik Biomedical Accelerator

Displaying: 11 - 20 of 46 Results

SIM-PAL: proteome wide identification of small molecule binding sites

Precise target identification for small molecules is an important and essential step in drug development. Despite its importance, there are very few unbiased, proteome-wide approaches aimed at identifying binding partners for small molecules. In…

Investigators

  • Christina Woo

Polycystic Kidney Disease: Mechanistic Dissection and Discovering Precision Therapeutic Targets

Autosomal-dominant polycystic kidney disease (ADPKD) is a life-threatening monogenic disease that affects nearly 1 million people in the U.S. alone. ADPKD represents a very large unmet medical need, currently without remedy. It is characterized by…

Investigators

  • Adrian Salic

Glp1r-ires-Cre (Glp1r-ires-Cre knock-in mice)

Glp1r (Glucagon-Like Peptide 1 Receptor) -ires-Cre knock-in mice were developed in Dr. Stephen Liberles lab at Harvard Medical School. IRES and Cre sequence were inserted after the gene Glp1r, thus the mouse strain expresses Cre recombinase in cells…

Investigators

  • Stephen D. Liberles

Gpr65-ires-Cre (Gpr65-ires-Cre knock-in mice)

Gpr65 (G Protein-Coupled Receptor 65) -ires-Cre knock-in mice were developed by Dr. Stephen Liberles and members of his lab at Harvard Medical School. In these mice, expression of Cre recombinase is controlled by Gpr65 promoter in Gpr65-positive…

Investigators

  • Stephen D. Liberles

CD1- mice developed in the laboratory of Dr. Michael Grusby

Homozygous Cd1tm1Gru knock-out mice (C.129S2-Cd1tm1Gru/J, also known as CD1-) were developed by Dr. Michael J. Grusby at Harvard University. The mutant mice are deficient in both the Cd1.1 and Cd1.2 genes, and lack the normal natural killer…

Investigators

  • Michael J. Grusby

B6.Cg-Shhtm1(EGFP/cre)Cjt/J mice developed in the laboratory of Dr. Clifford Tabin

This mouse stain, also known as Shhgfpcre was originally described in Cell in 2004. The mice express GFP in all cell expressing Shh, and specifically, in the distal posterior region of the limb buds of embryos aged embryonic day 10 to 12. Mice…

Investigators

  • Clifford Tabin

ROSA26 FLPeR mice developed in the laboratory of Dr. Susan Dymecki

Homozygous FLPe knock-in mice (B6N.129S4-Gt(ROSA)26Sortm1(FLP1)Dym/J, also known as ROSA26::FLPe knock in) were developed by Dr. Susan Dymecki using ROSA26 segments provided by Dr. Phillippe Soriano. The mouse strain carries the FLPe knock-in allele…

Investigators

  • Susan M. Dymecki

“TRUC mice” Tbx21-/-.Rag2-/- (BALB/c) mice developed by Dr. Laurie Glimcher

Homozygous T-bet-/- × RAG2-/- deficient mice were created in the laboratory of Dr. Glimcher at Harvard University. These mice develop a spontaneous jevenille ulcerative colitis resulting from a pro-inflammatory response to the commensal microbiota…

CDK5R1/p25 transgenic mice developed in the laboratory of Dr. Li-Huei Tsai

Hemizygous CDK5R1 transgenic mice (C57BL/6-Tg(tetO-CDK5R1/GFP)337Lht/J, also known as p25 Tg) were developed in the laboratory of a former HHMI investigator Dr. Li-Huei Tsai at Harvard University. The mice express CDK5R1/GFP fusion protein under the…

Studying interactions between essential bacterial ABC (ATP-binding cassette) transporter MsbA and bacterial LPS to pave the way for new antibiotic discovery

Gram-negative bacteria cause multiple infectious disease and are increasingly becoming resistant to antibiotics. However, development of drugs targeting these organisms is complicated by the extreme complexity of the structure of gram-negative cell…

Investigators

  • Maofu Liao

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