Glp1r (Glucagon-Like Peptide 1 Receptor) -ires-Cre knock-in mice were developed in Dr. Stephen Liberles lab at Harvard Medical School. IRES and Cre sequence were inserted after the gene Glp1r, thus the mouse strain expresses Cre recombinase in cells expressing Glp1r, allowing Cre-dependent conditional genetic manipulation. Glp1r signaling regulates insulin secretion and gastric and small bowel motility (Cell, 2016). GLP1 is known as a clinically potent anti-diabetic and anti-feeding hormone and Glp1r-ires-Cre mice allows for specific targeting of cells that detect GLP1.
The mouse strain can be used as a tool to study:
- Gut motility
- Gastrointestinal function
This strain also offers a unique tool for optogenetic studies.
The detailed description of the mouse strain can be found here.
The mouse strain is available for licensing from Harvard University and will be provided by The Jackson Laboratory.