CD1- mice developed in the laboratory of Dr. Michael Grusby
Homozygous Cd1tm1Gru knock-out mice (C.129S2-Cd1tm1Gru/J, also known as CD1-) were developed by Dr. Michael J. Grusby at Harvard University. The mutant mice are deficient in both the Cd1.1 and Cd1.2 genes, and lack the normal natural killer cell-like T cell subset (Science, 1997).
The detailed description of the mouse strain can be found here.
The mice can be used to study immunology and inflammatory conditions.
The mouse strain is available for licensing from Harvard University and will be provided by The Jackson Laboratory.