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Utilizing the herpes simplex virus-based vaccine vectors to develop a COVID-19 vaccine

Researchers in the lab of David Knipe have constructed the HSV-1 based vaccine vector HSV-1 d106S. The vector can express viral, bacterial, or cancer gene products and has been used to induce protective immunity in humanized mice against HIV and…


  • David Knipe

Novel adjuvants to enhance adaptive immune response of vaccines

Researchers in the lab of Ulrich von Andrian have discovered a novel adjuvanting behavior of a clinically approved and well-tolerated class of medicines known as bisphosphonates. The team is hoping to collaborate with manufacturers of COVID-19…


  • Ulrich von Andrian

Self-adjuvanting mRNA platform technology

Researchers in the lab of Prof. George Church at Harvard Medical School have developed a vaccine platform technology that can be applied to fields such as infectious diseases and oncology therapeutics. The team is looking to further demonstrate…


  • George Church

Evolution of Sequence-Defined Highly Functionalized Nucleic Acid Polymers

DESCRIPTION Template-directed synthesis of modified DNA sequences can provide a rich source of material for generating new therapies featuring modified nucleic acid polymers. The Liu lab has previously developed pioneering methods to generate…


  • David Liu

CD1- mice developed in the laboratory of Dr. Michael Grusby

Homozygous Cd1tm1Gru knock-out mice (C.129S2-Cd1tm1Gru/J, also known as CD1-) were developed by Dr. Michael J. Grusby at Harvard University. The mutant mice are deficient in both the Cd1.1 and Cd1.2 genes, and lack the normal natural killer…


  • Michael Grusby

A system for in vivo generation of protective CD8+ T lymphocytes and other cells of hematopoietic origin

Differentiated CD8+ effector T cells mediate long-term immunity and protection against infectious diseases and cancer. Naive T cells are refractory to transduction with viral vectors without extensive ex vivo manipulations. A team of researchers at…


  • Arlene Sharpe
  • Nicholas Haining

Microbiome reagents to treat inflammatory bowel disease and restore gut homeostasis

Reactive oxygen species (ROS) and oxidative stress are believed to cause and/or aggravate several diseases, including inflammatory diseases like inflammatory bowel disease (IBD). Antioxidants have the ability to neutralize the damaging effects of…


  • Wendy Garrett

Immunology and Computational Biology Partnership

Professors Diane Mathis and Christophe Benoist at Harvard Medical School, together with other world-renowned immunologists and computational biologists from multiple research institutions, have created the Immunological Genome Project – Immgen…


  • Diane Mathis
  • Christophe Benoist

Novel methods for generating regulatory T-cells

Regulatory T-cells (Tregs) are key mediators of peripheral tolerance that can actively suppress effector T-cells, inhibit inflammation and mediate self-tolerance. Unlike naturally occurring Tregs (nTregs) which develop in the thymus,…


  • Arlene Sharpe
  • Loise Francisco
  • Vijay Kuchroo

Novel target in NK cell mediated antigen specific memory responses

The von Andrian laboratory discovered a novel mechanism for inducing antigen specific immunological memory. Their research examines the role of a molecular target not previously known to be associated with the natural killer (NK) cell mediated…


  • Ulrich von Andrian
  • Silke Paust

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