Microbiome reagents to treat inflammatory bowel disease and restore gut homeostasis

Reactive oxygen species (ROS) and oxidative stress are believed to cause and/or aggravate several diseases, including inflammatory diseases like inflammatory bowel disease (IBD). Antioxidants have the ability to neutralize the damaging effects of ROS and reduce oxidative stress. The Garrett Lab has discovered that a lactic acid bacterium containing a specific antioxidative enzyme is capable of neutralizing ROS and attenuating colitis. The effects are carried out by a specific enzyme in these bacteria that undergoes targeted and controlled release in the gut. In addition to modulating inflammatory conditions, the bacteria may also help facilitate the maintenance of healthy oxidative levels in the intestine.

Intellectual Property Status: Patent(s) Pending