Grant R. Zimmermann

Managing Director of Business Development, Blavatnik Biomedical Accelerator

Displaying: 21 - 30 of 46 Results

Novel Antifungal Agent

The existing suite of clinically useful antifungals is limited. While amphotericin B and nystatin have been used widely over the past 50 years, they are associated with high toxicity and negligible oral bioavailability. Harvard researchers in the…

Investigators

  • Jon Clardy

Selectively targeting serotonergic neuron subtypes to create precision neuro-psychiatric therapeutics

Targeting central monoamine systems, such as the brain serotonergic neural system, continues to be the strategy of choice for the treatment of psychiatric disorders including depression and schizophrenia. Selective serotonin reuptake inhibitors…

Investigators

  • Susan M. Dymecki

Antibody Target and Biomarker for Oocytes and Egg Quality Profiling

Harvard researchers have identified a way to isolate and manipulate oogonial stem cells (OSCs) with greater efficacy and validity than current methods. OSCs facilitate oocyte production in the ovary and serve as a foundation for promising new…

Investigators

  • David Sinclair

Microbiome reagents to treat inflammatory bowel disease and restore gut homeostasis

Reactive oxygen species (ROS) and oxidative stress are believed to cause and/or aggravate several diseases, including inflammatory diseases like inflammatory bowel disease (IBD). Antioxidants have the ability to neutralize the damaging effects of…

Investigators

  • Wendy Garrett

Innovative microbiome anti-oxidants to repair UV damaged skin and slow aging

Ultraviolet (UV) radiation from the sun drives accumulation of reactive oxygen species (ROS) and inflammation in the skin. UV radiation also depletes skin cells of antioxidant enzymes, including superoxide dismutase (SOD). Increased ROS and…

Investigators

  • Wendy Garrett

Environmentally Safe, First-in-Class Mosquito Sterilant

Dr. Flaminia Catteruccia from the Harvard T.H. Chan School of Public Health has discovered a biopesticide that is capable of sterilizing mosquitoes while being safe for human and environmental health. Spraying pesticides is a common method to…

Investigators

  • Flaminia Catteruccia

Novel therapies for neural regeneration

Researchers at the Flanagan lab discovered a novel therapeutic approach for stimulation of neuronal regeneration. They demonstrated that type II receptor protein tyrosine phosphatases (RPTPs) get activated by several heparan sulfate proteoglycans…

Investigators

  • John G. Flanagan
  • Yingjie Shen
  • Alan Peter Tenney
  • Jerry Silver

The next generation of cholesterol screening - A personalized diagnostic index for the improved assessment of cardiovascular risk using a novel method for the measurement of lipoprotein subtypes

OpportunityThis program offers the next generation of cholesterol screening. In 2013, 96 million visits to doctors' offices in the US included a cholesterol test.Problem/Unmet needCurrent practice of measuring total HDL level in serum does not…

Investigators

  • Frank Sacks

Absolute quantification of Proteins (AQUA)

This invention provides methods, reagents and kits for obtaining absolute quantification of proteins and their modifications directly from cell lysates. In particular, the invention provides peptide internal standards for use in high performance…

Investigators

  • Steven P. Gygi
  • Scott A. Gerber

Monoclonal IgE anti-ovalbumin antibody

A laboratory from the Harvard School of Public Health has developed a monoclonal Ig E mouse anti-ovalbumin. This antibody is useful as a positive control in ELISA assays used to measure the level of IgE anti-ovalbumin antibodies in mouse models of…

Investigators

  • Lester Kobzik
  • Aiyappa M. Palecanda

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