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Grant R. Zimmermann
Managing Director of Business Development, Blavatnik Biomedical Accelerator
Displaying: 21 - 30 of 46 Results
Novel Antifungal Agent
The existing suite of clinically useful antifungals is limited. While amphotericin B and nystatin have been used widely over the past 50 years, they are associated with high toxicity and negligible oral bioavailability. Harvard researchers in the…
Investigators
- Jon Clardy
Selectively targeting serotonergic neuron subtypes to create precision neuro-psychiatric therapeutics
Targeting central monoamine systems, such as the brain serotonergic neural system, continues to be the strategy of choice for the treatment of psychiatric disorders including depression and schizophrenia. Selective serotonin reuptake inhibitors…
Investigators
- Susan M. Dymecki
Antibody Target and Biomarker for Oocytes and Egg Quality Profiling
Harvard researchers have identified a way to isolate and manipulate oogonial stem cells (OSCs) with greater efficacy and validity than current methods. OSCs facilitate oocyte production in the ovary and serve as a foundation for promising new…
Investigators
- David Sinclair
Microbiome reagents to treat inflammatory bowel disease and restore gut homeostasis
Reactive oxygen species (ROS) and oxidative stress are believed to cause and/or aggravate several diseases, including inflammatory diseases like inflammatory bowel disease (IBD). Antioxidants have the ability to neutralize the damaging effects of…
Investigators
- Wendy Garrett
Innovative microbiome anti-oxidants to repair UV damaged skin and slow aging
Ultraviolet (UV) radiation from the sun drives accumulation of reactive oxygen species (ROS) and inflammation in the skin. UV radiation also depletes skin cells of antioxidant enzymes, including superoxide dismutase (SOD). Increased ROS and…
Investigators
- Wendy Garrett
Environmentally Safe, First-in-Class Mosquito Sterilant
Dr. Flaminia Catteruccia from the Harvard T.H. Chan School of Public Health has discovered a biopesticide that is capable of sterilizing mosquitoes while being safe for human and environmental health. Spraying pesticides is a common method to…
Investigators
- Flaminia Catteruccia
Novel therapies for neural regeneration
Researchers at the Flanagan lab discovered a novel therapeutic approach for stimulation of neuronal regeneration. They demonstrated that type II receptor protein tyrosine phosphatases (RPTPs) get activated by several heparan sulfate proteoglycans…
Investigators
- John G. Flanagan
- Yingjie Shen
- Alan Peter Tenney
- Jerry Silver
The next generation of cholesterol screening - A personalized diagnostic index for the improved assessment of cardiovascular risk using a novel method for the measurement of lipoprotein subtypes
OpportunityThis program offers the next generation of cholesterol screening. In 2013, 96 million visits to doctors' offices in the US included a cholesterol test.Problem/Unmet needCurrent practice of measuring total HDL level in serum does not…
Investigators
- Frank Sacks
HEK293T cells stably express Divalent Metal Transporter-1 for use in a model system to screen for inhibitors of iron uptake
This invention is a cell-based screen that enables the rapid identification of iron transport inhibitors. From initial efforts, 10 small molecule inhibitors of transport have been identified, and ongoing studies focus on characterizing their…
Investigators
- Marianne Wessling-Resnick
- Peter Buckett
Homozygous IKKepsilon knockout mouse as an animal model for influenza virus infection
Homozygous IKKepsilon (inhibitor of kappaB kinase epsilon) mutant mice are used as animal models for influenza virus infection. Homozygous deletion results in a complete loss of the endogenous kinase function in lung, spleen, and embryonic…
Investigators
- Thomas Maniatis
- Benjamin R. tenOever