Homozygous T-bet-/- × RAG2-/- deficient mice were created in the laboratory of Dr. Glimcher at Harvard University. These mice develop a spontaneous jevenille ulcerative colitis resulting from a pro-inflammatory response to the commensal microbiota driven by dendritic cell and TNF-alpha. When cohoused with wild-type mice, this mouse strain can induce colitis in the normal hosts via transmission of the colitogenic intestinal microbiota (Cytokine, 2009).
The mice can be used to model:
- Spontaneous ulcerative colitis
- Host-commensal relations at mucosal surface
The mouse strain is available for licensing from Harvard University.