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Displaying: 1-10 of 33 Results
Antimicrobial agents targeting Gram-negative bacteria
Infections by multiple antibiotics-resistant bacteria have become a significant medical problem. However, the development of new antibiotics…
Investigators:
Jon Beckwith
Dana Boyd
Case #: 4891ARMMs – Microvesicles for Non-immunogenic Nucleic Acid and/or Protein Drug Delivery
Dr. Quan Lu has discovered a novel population of naturally secreted, non-immunogenic microvesicles that can deliver nucleic acid and protein…
Investigators:
Quan Lu
Case #: HU 4400/HU 5521Autophagy Enhancers for the Treatment of Neurodegeneration
An emerging startup from Junying Yuan's lab intends to develop three classes of small molecules for the treatment of neurodegenerative…
Investigators:
Junying Yuan
Case #:Cancer metabolism: SIRT4 as a key regulator of glutamine metabolism
Background - Cancer Metabolism: In many cancer cells, glutamine is the primary mitochondrial substrate and is required for maintenance of…
Investigators:
Marcia Haigis
Seungmin Jeong
Case #: 4188Cardiac glycosides as treatments for inflammatory and autoimmune diseases
Bufalin and other cardiac glycoside inhibitors of the sodium-potassium ATPase (sodium pump) potently inhibit the induction of the…
Investigators:
Thomas Maniatis
Junqiang Ye
Shuibing Chen
Case #: 3787Development of a Potent Allosteric Inhibitor of SHP2 Protein Suitable for Treatment Of Blood Cancers and Solid Tumors
The SHP2 protein, encoded by the PTPN11 gene in humans, is a tyrosine phosphatase that plays a critical role in the full activation of the…
Investigators:
Stephen Blacklow
Case #: 7193Harnessing microtubule stabilizers to treat neurodegenerative diseases
Normal assembly of microtubules (MT), cytoskeletal elements found in all mammalian cells, is critical for proper brain function. Conversely,…
Investigators:
Timothy Mitchison
Case #: 6598High-resolution single-particle cryo-electron microscopy enables studies of drug-target interactions and molecular mechanisms of disease
Large proteins, including membrane-embedded transporters and ion channels are targeted by multiple drugs. However, their complex structures…
Investigators:
Maofu Liao
Case #:In vitro models and method of treatment for amyotrophic lateral sclerosis (ALS)
It has been impossible to isolate viable human motor neurons from patients or from postmortem samples to investigate the mechanisms leading…
Investigators:
Kevin Eggan
Francesco Di Giorgio
Case #: 2964Inhibitors of protein-processivity factor
Harvard investigators have discovered that Pol interacts with a processivity factor at a site that is distinct from sites of normal…
Investigators:
Donald Coen
James Hogle
Harmon Zuccola
Kristie Bridges
Carl Elkin
Scott Lokey
Case #: 1613