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ARMMs – Microvesicles for Non-immunogenic Nucleic Acid and/or Protein Drug Delivery
Dr. Quan Lu has discovered a novel population of naturally secreted, non-immunogenic microvesicles that can deliver nucleic acid and protein…
Investigators:
Quan Lu
Autophagy Enhancers for the Treatment of Neurodegeneration
An emerging startup from Junying Yuan's lab intends to develop three classes of small molecules for the treatment of neurodegenerative…
Investigators:
Junying Yuan
Compounds that block human cytomegalovirus by targeting the nuclear egress complex
Researchers in Dr. Donald Coen’s lab have identified molecules that inhibit human cytomegalovirus (HCMV) virion egress from the cell,…
Investigators:
Donald Coen
In vitro models and method of treatment for amyotrophic lateral sclerosis (ALS)
It has been impossible to isolate viable human motor neurons from patients or from postmortem samples to investigate the mechanisms leading…
Investigators:
Kevin Eggan
Francesco Di Giorgio
Inhibitors of protein-processivity factor
Harvard investigators have discovered that Pol interacts with a processivity factor at a site that is distinct from sites of normal…
Investigators:
Donald Coen
James Hogle
Harmon Zuccola
Kristie Bridges
Carl Elkin
Scott Lokey
Ionic liquid aerosols for respiratory complications related to COVID-19
Researchers in the lab of Samir Mitragotri have developed ionic liquid aerosols that have the potential to combat pulmonary bacterial…
Investigators:
Samir Mitragotri
Lead compounds for the treatment of pain
The invention is a novel synthetic pathway to the generation of nonpeptidic ligands for the mu opioid class of G-protein coupled receptors.…
Investigators:
Gregory Verdine
Bryce Harrison
Tiffany Gierasch
Zhangjie Shi
Method for large-scale production of differentiated neurons
INTRODUCTIONHuman pluripotent stem cells (hPSC’s) can be used to generate a wide variety of somatic cell types. In addition, they…
Investigators:
Lee Rubin
Methods and compounds for the treatments of spinal muscular atrophy and ALS
Scientists in the Rubin laboratory have carried out an image-based screen of pharmacologically active small molecules to find compounds that…
Investigators:
Lee Rubin
Nina Makhortova
Yin Yang
Monica Bennett
Amy Sinor-Anderson
Novel annulation catalysts via direct C-H bond amination
Introducing functionality into unactivated C-H bonds, a ubiquitous group in organic molecules, remains a significant challenge due to the…
Investigators:
Theodore Betley
Elisabeth Hennessy
Alexandre Mikhailine
Claudia Kleinlein
Yuyang Dong
Yunjung Baek