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Guppy Tank: NoRI – Revolutionizing Digital Imaging

November 30th, 2022 ~ 04:00pm - 06:00pm

LabCentral, 700 Main Street North, Cambridge, MA

Harvard's Office of Technology Development and LabCentral invite you to the latest event in the Guppy Tank series, where Harvard life-science innovators pitch their concepts to a panel of entrepreneurs and investors for constructive, in-depth feedback.

Please join us at LabCentral on November 30 from 4:00 to 6:00 p.m. to learn from experts on startup formation and participate in giving audience feedback.

All guests visiting LabCentral must be fully vaccinated. Vaccination status will be checked by the event organizers upon arrival to the event.

Register Here


Naomi Fried, PhD – Founder and CEO, PharmStars

Jon Glickman, MD, PhD – VP, Head of Translational Pathology, PathAI

Adam Kundzewicz, PhD – Executive Director, Boehringer Ingelheim Venture Fund

Chandra Ramanathan, PhD – Global Head, Innovation Hubs, Danaher Corporation

Steve Tregay, PhD – Managing Partner at Mission BioCapital

Featured project:

NoRI – Revolutionizing Digital Imaging

Presented by Seungeun Oh, Ph.D, post doctoral researcher in the lab of Marc Kirschner at Harvard Medical School

The Kirschner lab has developed a novel image analysis algorithm, NoRI (Normalized Raman Imaging), that derives the absolute concentration of lipids, proteins, and water from label-free images generated using Simulated Raman Spectroscopy (SRS). This new dimension of quantitative data derived from qualitative images of tissues or cells could accelerate the advent of AI-enabled, digital histopathology diagnostics – a challenge that has proven difficult to address for a long time. In addition to digital pathology, this technology can also be applied to biomedical research in cases where the amount and distribution of protein and lipid mass is central, including but not limited to research in areas such as cancer, metabolic diseases, and neurodegenerative diseases.

Key Technical Advantages of NoRI

  • Absolute concentration measurement of protein, lipid, and water from in vitro culture or tissue samples.
  • Histological information from live or fixed samples without the need for staining, paraffin embedding, or thin sectioning.
  • 3-dimensional histology with very high spatial resolution and measurement sensitivity – able to resolve sub-cellular components in tissue samples over 100µm thick.
  • Inherently digital image data suitable for quantitative and remote histopathology.

Doctors Oh and Kirschner welcome constructive feedback from the Guppy Tank panelists, and from the audience, on the commercialization strategy for these innovations.

Tags: Guppy Tank

Press Contact: Kirsten Mabry | (617) 495-4157

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