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Displaying: 51 - 60 of 139 Results
Noggin Knock Out Mice
Homozygous mice are born but die shortly after birth, exhibiting multiple defects, including an open neural tube, skeletal abnormalities, shortened body axis, and a small vestigial tail. Analysis of early gene expression has shown that the loss of…
DBD
- Vivian Berlin
Investigators
- Andrew McMahon
Osr1GCE Knock In Mice
Homozygous mice die upon birth with multiple abnormalities of the heart and urogenital system (among other tissues). Heterozygous mice are viable and fertile. The Osr1eGFPCreERt2 (Osr1GCE) "knock-in" allele both abolishes Osr1 gene function and…
DBD
- Vivian Berlin
Investigators
- Andrew McMahon
Osx1-GFP::Cre Transgenic Mice
Mice hemizygous for this Osx1-GFP::Cre transgene are viable and fertile. The transgene carries both tTA under the regulation of the osterix (Sp7) promoter and, just downstream, a tetracycline responsive element (TRE; tetO)-controlled GFP/Cre fusion…
DBD
- Vivian Berlin
Investigators
- Andrew McMahon
p21CIP1/WAF1 Knock Out Mice
In this knockout strain, a neo cassette replaces exon 2 of the of the cyclin-dependent kinase inhibitor 1A (Cdkn1a or p21CIP1/WAF1) gene. Homozygotes are viable, fertile, and normal in size. P21CIP1/WAF1 is expressed, in a p53-dependent manner,…
DBD
- Irit Ben-Chelouche
Investigators
- Philip Leder
p26 Tg Transgenic Mice
Hemizygous transgenic mice are viable, fertile, normal in size and do not display any behavioral abnormalities. Mice homozygous for this transgene may not be viable. When these transgenic mice are bred with mice expressing the…
DBD
- Irit Ben-Chelouche
Investigators
- Li-Huei Tsai
p35 Knock Out Mice
At birth, mice homozygous for this targeted allele are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. Cdk5r protein product is not immunodetectable in homozygote whole-brain lysates. Histological…
DBD
- Irit Ben-Chelouche
Investigators
- Li-Huei Tsai
Pax4-cre Transgenic Mice
Pax4-cre transgenic mice have the mouse paired box gene 4 (Pax4) promoter directing expression of an enhanced green fluorescent protein fused to a Tet-off cassette (EGFP/tTA). The transgene also contains a tetracycline-responsive element with a CMV…
DBD
- Vivian Berlin
Investigators
- Douglas Melton
PDGFRa-CRE Transgenic Mice
Hemizygous Pdgfra-cre mice are viable and fertile, with cre expression directed to retinal Muller glial cells by the mouse Pdgfra (platelet derived growth factor receptor, alpha polypeptide) promoter. Expression is predominantly in the cell bodies…
DBD
- Grant Zimmermann
Investigators
- Connie Cepko
PD-L1 Knock Out Mice
The signal and all of the immunoglobulin (Ig)-V-like exon of the CD274 antigen (Cd274) gene were replaced with a neomycin resistance cassette, abolishing PD-L1 gene expression. PD-L1 is one of two ligands for PD-1 and is upregulated on antigen…
DBD
- Irit Ben-Chelouche
Investigators
- Arlene Sharpe
R26:FRAP Knock In Mice
These mice possess a disrupted human placental alkaline phosphatase (ALPP) transgene inserted into the Gt(ROSA)26Sor locus. Expression of the ALPP transgene is contingent upon Flp-mediated excision of the FRT-flanked STOP cassette placed between the…
DBD
- Grant Zimmermann
Investigators
- Susan Dymecki