Vivian Berlin

Executive Director, HMS

Displaying: 71 - 75 of 75 Results

Research Tool

Wnt7bc3 LoxP Targeted Mutation Mice

Mice homozygous for the Wnt7bc3 allele are viable and fertile, with loxP sites flanking exon 3 of the targeted gene. When bred to mice that express Cre recombinase, the resulting offspring will have this region deleted in the cre-expressing…

Investigators

  • Douglas Melton

Research Tool

Shh Knock Out Mice

Mice homozygous for the Shhtm1Amc targeted mutation display early defects in the establishment and maintenance of midline structures. These defects result from the critical role the Sonic hedgehog (Shh) gene plays in the patterning of vertebrate…

Investigators

  • Andrew P. McMahon

Research Tool

gene trap ROSA 26 Targeted Mutation Mice

These mice contain a sequence encoding an intracellular portion of the mouse Notch1 gene (amino acids 1749-2293), but lacking the c-terminal PEST domain, and Green Fluorescent Protein, GFP, inserted into the GT(ROSA)26Sor locus. Expression of the…

Investigators

  • Douglas Melton

Research Tool

Wnt11-myrTagRFP-IRES-CE Transgenic Mice

These Wnt11-myrTagRFP-IRES-CE mutant mice have a tamoxifen inducible Cre-mediated recombination system and express the Tag-RFPT variant of Red Fluorescent Protein under the direction of the mouse Wnt11, wingless-related MMTV integration site 11,…

Investigators

  • Andrew P. McMahon

Research Tool

Pax4-cre Transgenic Mice

Pax4-cre transgenic mice have the mouse paired box gene 4 (Pax4) promoter directing expression of an enhanced green fluorescent protein fused to a Tet-off cassette (EGFP/tTA). The transgene also contains a tetracycline-responsive element with a CMV…

Investigators

  • Douglas Melton

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