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Displaying: 1 - 10 of 21 Results

DNA Destruction Through Novel and Adaptable Enzymes

Bacteria in mixed populations compete for resources and have several strategies on surviving and dominating other bacterial species. One method employs the injection of lethal effectors into adjacent cells. These effectors can disrupt cell membranes…


  • Karine Gibbs

Promising new hand disinfection technology to eliminate pathogens

Pathogens found in the air and on surfaces present a massive global health challenge, threating human health and food security. With the increased prevalence of antibiotic-resistant bacteria and the use of harmful chemicals in typical…


  • Philip Demokritou
  • Georgios Pyrgiotakis
  • Joseph Brain
  • Nachiket Vaze
  • Mary Eleftheriadou

Novel annulation catalysts via direct C-H bond amination

Introducing functionality into unactivated C-H bonds, a ubiquitous group in organic molecules, remains a significant challenge due to the inertness of the substrate. Traditional synthesis strategies involve functional group exchange, an inefficient…


  • Theodore Betley
  • Elisabeth Hennessy
  • Alexandre Mikhailine
  • Claudia Kleinlein
  • Yuyang Dong
  • Yunjung Baek

Continuous directed evolution of aminoacyl-tRNA synthetases to alter amino acid specificity and enhance activity

DESCRIPTION Functions of various biotherapeutics can often be enhanced by modifying individual amino acid residues. However, the current approaches rely on existing natural amino acid chemistry. Approaches that provide new chemical “handles” will…


  • David Liu

Studying interactions between essential bacterial ABC (ATP-binding cassette) transporter MsbA and bacterial LPS to pave the way for new antibiotic discovery

Gram-negative bacteria cause multiple infectious disease and are increasingly becoming resistant to antibiotics. However, development of drugs targeting these organisms is complicated by the extreme complexity of the structure of gram-negative cell…


  • Maofu Liao

Intracellular delivery of proteins: Aurin 1.2, an efficient non-endosomal protein delivery platform

To fully realize the therapeutic potential of proteins, exogenous proteins need to access intracellular targets. Since the vast majority of proteins cannot spontaneously cross cell membranes, a range of delivery platforms have been developed. These…


  • David Liu

First in class substrate-selective Insulin Degrading Enzyme (IDE) inhibitors for treating Diabetes

First in class substrate-selective Insulin Degrading Enzyme (IDE) inhibitors for treating Diabetes. Professor David Liu and a multidisciplinary research team have recently discovered and optimized of a series of small molecules (<550 Da, IC50 = 1…


  • David Liu
  • Juan Pablo Maianti

Highly specific chemical detection using NMR at low magnetic fields

NMR often does not have sufficient resolution to distinguish between chemicals with related or similar structures in the presence of a large background, which leads to poor chemical specificity. The NMR spectra of complex chemical mixtures may…


  • Ronald Walsworth
  • Matthew Rosen
  • Stephen DeVience

Microfluidic arrays for multiplex detection of analyts

This invention is a microfluidic array apparatus and a method of performing multiple analyses on multiple samples simultaneously, utilizing nanoliter volumes of reagents. It has two embodiments, the first consists of N microfluidic channels, perhaps…


  • George Whitesides
  • Rustem Ismagilov
  • Jessamine Lee
  • Paul Kenis
  • Xingyu Jiang
  • Rosaria Ferrigno

Highly conformal tungsten nitride films for use in microelectronics and semiconductors

The invention describes a method of producing a uniform, smooth and conformal coating of tungsten nitride, synthesized by atomic layer deposition (ALD). The silver-colored coating (or film) is metallic and a good electrical conductor.


  • Roy Gordon
  • Jill Becker
  • Seigi Suh

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