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Displaying: 1 - 8 of 8 Results
Platform for AAV Delivery to Skin
Emerging startup: A platform technology from George Church's lab enables delivery of gene therapy via the skin. (Image credit: Carl Schoellhammer, Denitsa Milanova, Humberto Trevino, Cody Cleveland, Jeff Wyckoff, Anna Mandinova, George Church,…
DBD
- Grant Zimmermann
Investigators
- George Church
Evolution of Sequence-Defined Highly Functionalized Nucleic Acid Polymers
DESCRIPTION Template-directed synthesis of modified DNA sequences can provide a rich source of material for generating new therapies featuring modified nucleic acid polymers. The Liu lab has previously developed pioneering methods to generate…
DBD
- Irit Ben-Chelouche
Investigators
- David Liu
Innovative microbiome anti-oxidants to repair UV damaged skin and slow aging
Ultraviolet (UV) radiation from the sun drives accumulation of reactive oxygen species (ROS) and inflammation in the skin. UV radiation also depletes skin cells of antioxidant enzymes, including superoxide dismutase (SOD). Increased ROS and…
DBD
- Grant Zimmermann
Investigators
- Wendy Garrett
Preventing Stress-Induced Greying of Hair
Loss of hair pigmentation has long been associated with stress; however, stress-related changes at the level of the somatic cell have only recently been elucidated. The hair follicle consists of two stem cell populations: epithelial-derived hair…
DBD
- Yelena Bisharyan
Investigators
- Ya-Chieh Hsu
- Bing Zhang
Regeneration of Skin Tissue
The amazing regenerative capability of fetal skin has been known for decades. While postnatal skin heals through fibrosis (scar formation) and only the epidermis can be restored, fetal skin has enormous regenerative capability and heals without scar…
DBD
- Yelena Bisharyan
Investigators
- Ya-Chieh Hsu
Targeting Mechanisms of Stress or Age-Related Skin Hyperpigmentation
Pigmentation is highly heritable, as genetic factors modulate the amount and distribution of melanin to the skin, hair, and eyes. However, endocrine factors associated with stress, pregnancy, and aging often induce temporary or permanent changes in…
DBD
- Yelena Bisharyan
Investigators
- Ya-Chieh Hsu
Localized Modulation of Hair Growth or Hair Suppression
Although hair loss is common, it is often considered an undesirable outcome. Another popular opinion is that body hair can be just as unpleasant. Hair growth undergoes a cycle of rest and growth, where hair follicle stem cells (HFSCs) either remain…
DBD
- Yelena Bisharyan
Investigators
- Ya-Chieh Hsu
Targeting Mechanisms of Stress-Related Hair Loss
More than 80 percent of men and nearly half of women experience significant hair loss during their lifetime. For many, the thinning begins well before middle age. Everyone has a story to share about the annoying effects of hair loss, which range…
DBD
- Yelena Bisharyan
Investigators
- Ya-Chieh Hsu