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Displaying: 91 - 100 of 270 Results
Non-invasive real-time detection of hardware trojans
Integrated circuit (IC) trojans are a significant security threat to our communications, cloud and IT infrastructure. These rogue modifications to semiconductors can be triggered at any point and represent a latent risk. A hostile government or…
DBD
- Sam Liss
Investigators
- Marko Loncar
- Linbo Shao
Liquid biopsy-based predictive platform for early cancer detection and drug discovery
Recognition and management of individuals susceptible to disease are critical for patient care. However, identification of these patients is very challenging, especially in oncology. Dr. Peter Park and his group at the Department of Biomedical…
DBD
- Irit Ben-Chelouche
Investigators
- Peter Park
Wearable gait analysis system for measuring overstriding in runners
Roughly 50% of the 20 million active runners in the United States are injured each year, with overstriding being a major cause. Proper gait is essential to minimizing the risk of injury, but perfecting it requires constant monitoring of one's…
DBD
- Sam Liss
Investigators
- Conor Walsh
- Panagiotis Polygerinos
- Daniel Lieberman
- Stephanie Liu
Strong and flexible hydrogels below water freezing temperature
Hydrogels are highly absorbent gels in which the swelling agent is water. They’re used in a wide range of biomedical and commercial applications, such as tissue engineering, wound healing, cell culture, contact lenses, and disposable diapers. This…
DBD
- Christopher Petty
Investigators
- Joost Vlassak
- Widusha Illeperuma
- Zhigang Suo
First in class substrate-selective Insulin Degrading Enzyme (IDE) inhibitors for treating Diabetes
First in class substrate-selective Insulin Degrading Enzyme (IDE) inhibitors for treating Diabetes. Professor David Liu and a multidisciplinary research team have recently discovered and optimized of a series of small molecules (<550 Da, IC50 = 1…
DBD
- Irit Ben-Chelouche
Investigators
- David Liu
- Juan Pablo Maianti
Therapeutic strategies for autism spectrum disorder sensory (tactile) hypersensitivity, anxiety and social interaction deficits
This is a novel strategy to treat tactile hypersensitivity, anxiety, and social interaction deficits by targeting the peripheral nervous system without drugging the brain.Autism spectrum disorders (ASDs), including Rett Syndrome, as well as Fragile…
DBD
- Irit Ben-Chelouche
Investigators
- David Ginty
- Lauren Orefice
A novel and effective technology for target-based screening
Target-based screening allows for rapid identification of ligands for an increasing number of macromolecular targets and is commonly used in drug discovery.The present invention uses interaction-dependent PCR (IDPCR) to selectively identify…
DBD
- Irit Ben-Chelouche
Investigators
- David Liu
- Christoph Dumelin
- David Gorin
- Lynn McGregor
Highly specific chemical detection using NMR at low magnetic fields
NMR often does not have sufficient resolution to distinguish between chemicals with related or similar structures in the presence of a large background, which leads to poor chemical specificity. The NMR spectra of complex chemical mixtures may…
Investigators
- Ronald Walsworth
- Matthew Rosen
- Stephen DeVience
Photostick: Physical isolation of single cells from tissue, for further propagation and single cell sequencing and omics
Photostick enables the physical selection of single cells from large populations in diverse environments. The novel process entails photochemical immobilization of live cells with patterned illumination, followed by removal of unwanted cells with…
DBD
- Yelena Bisharyan
Investigators
- Adam Cohen
- Miao-Ping Chien
Enhancers of Gene Therapy
Currently available gene therapy technologies rely on either plasmid DNA or viral vector transduction to enable gene transfer. However, such methods often suffer from poor direct expression and insufficient incorporation of foreign genetic material.…
DBD
- Vivian Berlin
Investigators
- David Knipe
- Megan Orzalli