Homozygous Transient Receptor Potential Cation Channel Subfamily A Member 1 (TRPA1) mutant mice (B6;129P-Trpa1tm1Kykw/J, also known as Trpa1 KO) were developed by HHMI Investigator David Corey at Harvard Medical School. They exhibit abnormal behaviors in response to tactile, cold, and chemical stimuli (Neuron, 2006). The mutant mice are viable and fertile, but show loss of fertility after 5-6 months of age. Trpa1 KO mice have a normal auditory and vestibular function.
The detailed description of the mouse strain can be found here.
The mice can be used to model the following conditions:
- Temperature sensitivity
- Sensitivity to touch
The mouse strain is available for licensing from Harvard University and will be provided by The Jackson Laboratory.