Crx GFPAP Transgenic Mice

Hemizygotes are viable and fertile. Expression of human placental alkaline phosphatase (PLAP) and GFP recapitulates that of the endogenous Crx promoter in the retina at embryonic time points as early as embryonic day 12.5 (E12.5) and in the retina of the adult mouse. This line also shows a more sensitive detection of Crx expression in the optic nerve of the developing retina. PLAP (but not GFP) expression is also found in fresh frozen pineal gland samples collected from adult mice. The Jackson Laboratory 2024, used with permission.

Jax Stock Number: 7066