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Displaying: 31 - 40 of 139 Results
FoxD1GC Transgenic Mice
Heterozygous mice are viable and fertile, normal in size and do not display any gross physical or behavioral abnormalities. The DI states that the strain is homozygous lethal. The FoxD1GC allele expresses an eGFPCre fusion protein (EGFP and cre…
DBD
- Vivian Berlin
Investigators
- Andrew McMahon
FoxD1GCE eGFPCreERT2 Transgenic Mice
Heterozygous mice are viable and fertile, normal in size and do not display any gross physical or behavioral abnormalities. The DI states that the strain is homozygous lethal. The Foxd1GCE allele expresses an eGFPCreERT2 fusion protein (EGFP and…
DBD
- Vivian Berlin
Investigators
- Andrew McMahon
gene trap ROSA 26 Targeted Mutation Mice
These mice contain a sequence encoding an intracellular portion of the mouse Notch1 gene (amino acids 1749-2293), but lacking the c-terminal PEST domain, and Green Fluorescent Protein, GFP, inserted into the GT(ROSA)26Sor locus. Expression of the…
DBD
- Vivian Berlin
Investigators
- Douglas Melton
Glar2 Knock Out Mice
Mice homozygous for this targeted mutation are viable and fertile and do not display any gross physical or behavioral abnormalities. There is no identifiable phenotype in these mice. Expression is eliminated in the brain as determined by RT-PCR and…
DBD
- Grant Zimmermann
Investigators
- Connie Cepko
Hba-a1 Targeted Mutation Mice
Mice that are homozygous for the targeted mutation are viable and fertile, but are anemic. Reduced levels of gene product (mRNA) are detected by Northern blot analysis of homozygous embryos (due to compensatory expression of the _2-globin gene).…
DBD
- Irit Ben-Chelouche
Investigators
- Philip Leder
Hbva-x Targeted Mutation Mice
Mice that are homozygous for this targeted mutation have an embryonic lethal phenotype. No gene product (mRNA) is detected by Northern blot analysis of homozygous embryos. _-globin mRNA expression is also reduced in homozygous embryos. Homozygous…
DBD
- Irit Ben-Chelouche
Investigators
- Philip Leder
Hoxb7-cre Transgenic Mice
Mice hemizygous for the transgenic insert are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. Homozygotes are not viable. These transgenic mice express the Cre recombinase under the control of the…
DBD
- Vivian Berlin
Investigators
- Andrew McMahon
Ihh Knock Out Mice
Mice that are heterozygous for the targeted allele are viable and fertile. Mice homozygous for this mutation have a lethal phenotype. Half of homozygous null mice have an embryonic lethal phenotype, dying between 10.5 to 12.5 days post coitum. The…
DBD
- Vivian Berlin
Investigators
- Andrew McMahon
Ihh Transgenic Mice
Mice heterozygous for this targeted mutation are viable and fertile. Homozygotes die from respiratory failure shortly after birth. Expression of the "knocked-in" lacZ gene is detected in a pattern similar to the endogenous transcript (in lung,…
DBD
- Vivian Berlin
Investigators
- Andrew McMahon
Irf8 Knock Out Mice
Mice homozygous for this Irf8 knockout allele (Irf8-/-) may be expected to to exhibit some or all of the phenotype published for other Irf8 null mutations on both a C57BL/6J-congenic and mixed genetic background. For example, other Ifr8 null mice…
DBD
- Vivian Berlin
Investigators
- Andrew McMahon