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Stat4 Knock Out mice

Mice homozygous for the Stat4tm1Gru mutation are viable and fertile. IL12 induced interferon-gamma secretion and stimulation of lymphocytes are defective. Development of Th1 cells in response to either IL12 or Listeria monocytogenes is also…

DBD

  • Irit Ben-Chelouche

Investigators

  • Michael Grusby

T-bet Knock Out Mice

The Tbx21 gene encodes a transcription factor that controls expression of interferon-gamma and is involved in Th1 cell lineage development. Mice that are homozygous for this targeted mutation of Tbx21, in which a NEO cassette replaces 2 Kb of…

Investigators

  • Laurie Glimcher

Thy1-Brainbow 1.0 Trangenic Mice

These Thy1-Brainbow 1.0 (line L) transgenic mice are viable and fertile. The mice possess multiple fluorescent protein sequences uniquely flanked with pairs of incompatible Lox sites alternated to create mutually exclusive recombination events;…

DBD

  • Irit Ben-Chelouche

Investigators

  • Jeffrey Lichtman

Thy1-Brainbow 1.1 Transgenic Mice

These Thy1-Brainbow 1.1 (line M) transgenic mice are viable and fertile. The mice possess multiple fluorescent protein sequences uniquely flanked with pairs of incompatible Lox sites alternated to create mutually exclusive recombination events;…

DBD

  • Irit Ben-Chelouche

Investigators

  • Jeffrey Lichtman

Thy1-Brainbow 2.1 Transgenic Mice

These Thy1-Brainbow 2.1 (line R) transgenic mice are viable and fertile. The mice possess two invertible DNA segments (four fluorescent protein sequences in total) uniquely positioned in tandem and flanked with LoxP sites to generate a larger number…

DBD

  • Irit Ben-Chelouche

Investigators

  • Jeffrey Lichtman

Thy1-Brainbow Transgenic Mice

These Thy1-Brainbow 1.0 (line H) transgenic mice are viable and fertile. The mice possess multiple fluorescent protein sequences uniquely flanked with pairs of incompatible Lox sites alternated to create mutually exclusive recombination events;…

DBD

  • Irit Ben-Chelouche

Investigators

  • Jeffrey Lichtman

Thy1-CFP-MitoC Transgenic Mice

These transgenic mice express Cyan Fluorescent Protein (CFP) under the control of the mouse thymus cell antigen 1, theta, Thy1, promoter. CFP is specifically localized to the mitochondria by a human cytochrome c oxidase, subunit 8A (ubiquitous),…

DBD

  • Irit Ben-Chelouche

Investigators

  • Jeffrey Lichtman

Thy1-CFP-MitoS Transgenic Mice

These transgenic mice express Cyan Fluorescent Protein (CFP) under the control of the mouse thymus cell antigen 1, theta, Thy1, promoter. CFP is specifically localized to the mitochondria by a human cytochrome c oxidase, subunit 8A (ubiquitous),…

DBD

  • Irit Ben-Chelouche

Investigators

  • Jeffrey Lichtman

Tmem100-GCE Transgemic Mice

These transgenic mice express the eGFPCreERT2 (Enhanced Green Fluorescent Protein and cre/ESR1) fusion gene under the direction of the mouse Tmem100, transmembrane protein 100, promoter. Transgene expression is detected in developing nephrons of the…

DBD

  • Vivian Berlin

Investigators

  • Andrew McMahon

Top2beta Flox2 Targeted Mutation Mice

These mice possess loxP sites flanking the 3 exons encoding the active-site tyrosyl residue of the targeted gene. Mice that are homozygous for this allele are viable, fertile, normal in size and do not display any gross physical or behavioral…

DBD

  • Grant Zimmermann

Investigators

  • James Wang

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