DBD Search
Irit Ben-Chelouche
Director of Business Development, Harvard Medical School
Displaying: 61 - 70 of 80 Results
Research Tool
Fmn1 Knock Out Mice
Mice that are homozygous for the targeted mutation are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. None of the major splice variants of Fmn1 are detected by Northern blot analysis. No gene…
Investigators
- Philip Leder
Research Tool
Ror2f/f Targeted Mutation Mice
These Ror2f/f mutant mice possess loxP sites flanking exons 3-4 of the receptor tyrosine kinase-like orphan receptor 2 (Ror2) gene. Mice that are homozygous for this allele are viable, fertile, normal in size and do not display any gross physical or…
Investigators
- Michael E Greenberg
Research Tool
Blmlox Targeted Mutation Mice
These mice possess loxP sites on either side of exon 8 of the targeted gene. Mice that are homozygous for this allele are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. When these mutant mice are…
Investigators
- Philip Leder
Research Tool
PD-1- Targeted Mutation Mice
PD-1-/-mice lack exons 2-3 of the programmed cell death 1 (Pdcd1) gene. Mice that are homozygous for this allele are viable and fertile. PD-1 is an inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and…
Investigators
- Arlene H. Sharpe
Research Tool
NOD.DQ8, H2-Ab0null,Rag1null Mice
Rag1 and H2-Ab1 deficient NOD mice carrying transgenes coding for human CD2-CD4 and HLA-DQ8 lack T and B cells, and are diabetes free. Also, unlike the H2-Ab1 deficient, transgenic CD4, HLA-DQ8 mice (see Stock No. 006021), this strain does not…
Investigators
- Michael J. Grusby
Research Tool
Thy1-CFP-MitoS Transgenic Mice
These transgenic mice express Cyan Fluorescent Protein (CFP) under the control of the mouse thymus cell antigen 1, theta, Thy1, promoter. CFP is specifically localized to the mitochondria by a human cytochrome c oxidase, subunit 8A (ubiquitous),…
Investigators
- Jeffrey W. Lichtman
Research Tool
Fmn2 Knock Out Mice
The proline-rich FH1 domain of the formin 2 (Fmn2) gene was disrupted with a neomycin resistance (neo) cassette, abolishing FH1 domain binding function. Formin 2, a straight-actin-filament nucleator expressed in neurons of the central nervous…
Investigators
- Philip Leder
Research Tool
Stat4 Knock Out mice
Mice homozygous for the Stat4tm1Gru mutation are viable and fertile. IL12 induced interferon-gamma secretion and stimulation of lymphocytes are defective. Development of Th1 cells in response to either IL12 or Listeria monocytogenes is also…
Investigators
- Michael J. Grusby
Research Tool
Cd1 Knock Out Mice
Mice homozygous for the Cd1tm1Gru targeted mutation are deficient in both the Cd1d1 and Cd1d2 genes (CD1.1, CD1.2). Homozygous mutant mice lack the normal natural killer cell-like T cell subset. However, type 2 T helper cell (TH2) response is…
Investigators
- Michael J. Grusby
Research Tool
CD1-deficient BXSB.Yaa Knock Out Mice
BXSB.Yaa CD1-/- (BXSB.Yaa Cd1d1/Cd1d2-/-) mice are a BXSB-congenic strain carrying a null mutation of the CD1 antigen complex; both CD1.1 (Cd1d1) and CD1.2 (Cd1d2) expression is abolished. Homozygous (CD1-/-) mice are natural killer T cell…
Investigators
- Michael J. Grusby