DBD Search
Irit Ben-Chelouche
Director of Business Development, Harvard Medical School
Displaying: 61 - 70 of 80 Results
Research Tool
Thy1-CFP-MitoS Transgenic Mice
These transgenic mice express Cyan Fluorescent Protein (CFP) under the control of the mouse thymus cell antigen 1, theta, Thy1, promoter. CFP is specifically localized to the mitochondria by a human cytochrome c oxidase, subunit 8A (ubiquitous),…
Investigators
- Jeffrey W. Lichtman
Research Tool
Fat3lox Targeted Mutation Mice
FAT3, an atypical cadherin protein, is expressed on amacrine cell (AC) processes in the developing and mature inner plexiform layer (IPL) of the retina and is associated with dendrite morphogenesis. These mutant mice possess loxP sites flanking exon…
Investigators
- Lisa Goodrich
Research Tool
Cx37 Knock Out Mice
The Gja4 gene encodes an intercellular channel forming protein, also known as Connexin 37, that is a component of gap junctions. These mice carry a knock out mutation of the Gja4 gene in which a PGK-NEO cassette replaces almost the entire coding…
Research Tool
p35 Knock Out Mice
At birth, mice homozygous for this targeted allele are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. Cdk5r protein product is not immunodetectable in homozygote whole-brain lysates. Histological…
Investigators
- Li-Huei Tsai
Research Tool
Transmembrane IL-4 Knock In mice
This strain was made using gene targeting in embryonic stem cells to modify the Il4 locus by knocking-in a transmembrane domain. Expression of Il4 in a membrane-bound form provides a novel method for the identification and characterization of…
Investigators
- Michael J. Grusby
Research Tool
Fmn1 Knock Out Mice
Mice that are homozygous for the targeted mutation are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. None of the major splice variants of Fmn1 are detected by Northern blot analysis. No gene…
Investigators
- Philip Leder
Research Tool
PD-L1 Knock Out Mice
The signal and all of the immunoglobulin (Ig)-V-like exon of the CD274 antigen (Cd274) gene were replaced with a neomycin resistance cassette, abolishing PD-L1 gene expression. PD-L1 is one of two ligands for PD-1 and is upregulated on antigen…
Investigators
- Arlene H. Sharpe
Research Tool
Trpa1 Knock Out Mice
Homozygous mice are viable and fertile. The donating investigator reports a dramatic loss of fecundity after 5-6 months of age. The targeting vector contains an endoplasmic reticulum (ER) retention signal (KDEL), which is reported to sequester the…
Investigators
- David P. Corey
Research Tool
Fmn2 Knock Out Mice
The proline-rich FH1 domain of the formin 2 (Fmn2) gene was disrupted with a neomycin resistance (neo) cassette, abolishing FH1 domain binding function. Formin 2, a straight-actin-filament nucleator expressed in neurons of the central nervous…
Investigators
- Philip Leder
Research Tool
Ror1f/f Targeted Mutation Mice
These Ror1f/f mutant mice possess loxP sites flanking exons 3-4 of the receptor tyrosine kinase-like orphan receptor 1 (Ror1) gene. Mice that are homozygous for this allele are viable and fertile. ROR1 is a receptor for Wnt5a-mediated signaling.…
Investigators
- Michael E Greenberg