DBD Search
Irit Ben-Chelouche
Director of Business Development, Harvard Medical School
Displaying: 61 - 70 of 80 Results
Research Tool
7B2 Knock Out Mice
While heterozygotes are viable and fertile, mice homozygous for this mutation (7B2-null) die in prepubertal or pubertal ages (5 weeks) with severe cardio-respiratory failure, convulsions, and hypothermia. No transcripts are detected in brain tissue…
Research Tool
YY1lox Targeted Mutation Mice
These mice possess loxP sites on either side of exon 1 of the targeted gene. Mice that are homozygous for this allele are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. When these mutant mice are…
Investigators
- Yang Shi
Research Tool
NOD.DQ8, H2-Ab0null Mice
The NOD transgenic HLA DQ8, H2-Ab1deficient mouse is diabetes resistant but develops cardiomyopathy resulting in early death from heart failure in both males and females. Histological exam indicates hearts are 3-4x larger than wildtype. Pathology…
Investigators
- Michael J. Grusby
Research Tool
Thy1-CFP-MitoC Transgenic Mice
These transgenic mice express Cyan Fluorescent Protein (CFP) under the control of the mouse thymus cell antigen 1, theta, Thy1, promoter. CFP is specifically localized to the mitochondria by a human cytochrome c oxidase, subunit 8A (ubiquitous),…
Investigators
- Jeffrey W. Lichtman
Research Tool
Fmn1 Knock Out Mice
Mice that are homozygous for the targeted mutation are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. None of the major splice variants of Fmn1 are detected by Northern blot analysis. No gene…
Investigators
- Philip Leder
Research Tool
Ror2f/f Targeted Mutation Mice
These Ror2f/f mutant mice possess loxP sites flanking exons 3-4 of the receptor tyrosine kinase-like orphan receptor 2 (Ror2) gene. Mice that are homozygous for this allele are viable, fertile, normal in size and do not display any gross physical or…
Investigators
- Michael E Greenberg
Research Tool
Blmlox Targeted Mutation Mice
These mice possess loxP sites on either side of exon 8 of the targeted gene. Mice that are homozygous for this allele are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. When these mutant mice are…
Investigators
- Philip Leder
Research Tool
PD-1- Targeted Mutation Mice
PD-1-/-mice lack exons 2-3 of the programmed cell death 1 (Pdcd1) gene. Mice that are homozygous for this allele are viable and fertile. PD-1 is an inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and…
Investigators
- Arlene H. Sharpe
Research Tool
NOD.DQ8, H2-Ab0null,Rag1null Mice
Rag1 and H2-Ab1 deficient NOD mice carrying transgenes coding for human CD2-CD4 and HLA-DQ8 lack T and B cells, and are diabetes free. Also, unlike the H2-Ab1 deficient, transgenic CD4, HLA-DQ8 mice (see Stock No. 006021), this strain does not…
Investigators
- Michael J. Grusby
Research Tool
Thy1-CFP-MitoS Transgenic Mice
These transgenic mice express Cyan Fluorescent Protein (CFP) under the control of the mouse thymus cell antigen 1, theta, Thy1, promoter. CFP is specifically localized to the mitochondria by a human cytochrome c oxidase, subunit 8A (ubiquitous),…
Investigators
- Jeffrey W. Lichtman