DBD Search
Irit Ben-Chelouche
Director of Business Development, Harvard Medical School
Displaying: 71 - 80 of 80 Results
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Blmlox Targeted Mutation Mice
These mice possess loxP sites on either side of exon 8 of the targeted gene. Mice that are homozygous for this allele are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. When these mutant mice are…
Investigators
- Philip Leder
Research Tool
PD-1- Targeted Mutation Mice
PD-1-/-mice lack exons 2-3 of the programmed cell death 1 (Pdcd1) gene. Mice that are homozygous for this allele are viable and fertile. PD-1 is an inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and…
Investigators
- Arlene H. Sharpe
Research Tool
NOD.DQ6, H2-Ab0null,Rag1null
Rag1 and H2-Ab1 deficient NOD mice carrying transgenes encoding humanized CD4 and HLA-DQ6 lack T and B cells and are free of autoimmune diabetes and cardiomyopathy, and do not develop thyroiditis. This model is useful in adoptive transfer…
Investigators
- Michael J. Grusby
Research Tool
Thy1-Brainbow 1.1 Transgenic Mice
These Thy1-Brainbow 1.1 (line M) transgenic mice are viable and fertile. The mice possess multiple fluorescent protein sequences uniquely flanked with pairs of incompatible Lox sites alternated to create mutually exclusive recombination events;…
Investigators
- Jeffrey W. Lichtman
Research Tool
Cd1 Knock Out Mice
Mice homozygous for the Cd1tm1Gru targeted mutation are deficient in both the Cd1d1 and Cd1d2 genes (CD1.1, CD1.2). Homozygous mutant mice lack the normal natural killer cell-like T cell subset. However, type 2 T helper cell (TH2) response is…
Investigators
- Michael J. Grusby
Research Tool
CD1-deficient BXSB.Yaa Knock Out Mice
BXSB.Yaa CD1-/- (BXSB.Yaa Cd1d1/Cd1d2-/-) mice are a BXSB-congenic strain carrying a null mutation of the CD1 antigen complex; both CD1.1 (Cd1d1) and CD1.2 (Cd1d2) expression is abolished. Homozygous (CD1-/-) mice are natural killer T cell…
Investigators
- Michael J. Grusby
Research Tool
NOD.DQ8, H2-Ab0null Mice
The NOD transgenic HLA DQ8, H2-Ab1deficient mouse is diabetes resistant but develops cardiomyopathy resulting in early death from heart failure in both males and females. Histological exam indicates hearts are 3-4x larger than wildtype. Pathology…
Investigators
- Michael J. Grusby
Research Tool
Thy1-Brainbow 2.1 Transgenic Mice
These Thy1-Brainbow 2.1 (line R) transgenic mice are viable and fertile. The mice possess two invertible DNA segments (four fluorescent protein sequences in total) uniquely positioned in tandem and flanked with LoxP sites to generate a larger number…
Investigators
- Jeffrey W. Lichtman
Research Tool
Cdk5lox Targeted Mutation Mice
These Cdk5 floxed mutant mice possess loxP sites flanking exons 1-5. Mice that are homozygous for this allele are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. When bred to mice that express Cre…
Investigators
- Li-Huei Tsai
Research Tool
Slamf2 Knock Out Mice
The Cd48 gene, also know as Slamf2 (signaling lymphocytic activation molecule 2), encodes for a lymphocyte cell surface antigen that binds CD2 and CD244 and is involved in regulation of T cell activation. These mice carry a targeted mutation for…
Investigators
- Arlene H. Sharpe