Irit Ben-Chelouche

Director of Business Development, Harvard Medical School

Displaying: 71 - 80 of 80 Results

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Cx37 Knock Out Mice

The Gja4 gene encodes an intercellular channel forming protein, also known as Connexin 37, that is a component of gap junctions. These mice carry a knock out mutation of the Gja4 gene in which a PGK-NEO cassette replaces almost the entire coding…

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Ror1f/f Targeted Mutation Mice

These Ror1f/f mutant mice possess loxP sites flanking exons 3-4 of the receptor tyrosine kinase-like orphan receptor 1 (Ror1) gene. Mice that are homozygous for this allele are viable and fertile. ROR1 is a receptor for Wnt5a-mediated signaling.…

Investigators

  • Michael E Greenberg

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7B2 Knock Out Mice

While heterozygotes are viable and fertile, mice homozygous for this mutation (7B2-null) die in prepubertal or pubertal ages (5 weeks) with severe cardio-respiratory failure, convulsions, and hypothermia. No transcripts are detected in brain tissue…

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YY1lox Targeted Mutation Mice

These mice possess loxP sites on either side of exon 1 of the targeted gene. Mice that are homozygous for this allele are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. When these mutant mice are…

Investigators

  • Yang Shi

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NOD.DQ8, H2-Ab0null Mice

The NOD transgenic HLA DQ8, H2-Ab1deficient mouse is diabetes resistant but develops cardiomyopathy resulting in early death from heart failure in both males and females. Histological exam indicates hearts are 3-4x larger than wildtype. Pathology…

Investigators

  • Michael J. Grusby

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Thy1-CFP-MitoC Transgenic Mice

These transgenic mice express Cyan Fluorescent Protein (CFP) under the control of the mouse thymus cell antigen 1, theta, Thy1, promoter. CFP is specifically localized to the mitochondria by a human cytochrome c oxidase, subunit 8A (ubiquitous),…

Investigators

  • Jeffrey W. Lichtman

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Fmn1 Knock Out Mice

Mice that are homozygous for the targeted mutation are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. None of the major splice variants of Fmn1 are detected by Northern blot analysis. No gene…

Investigators

  • Philip Leder

Research Tool

Ror2f/f Targeted Mutation Mice

These Ror2f/f mutant mice possess loxP sites flanking exons 3-4 of the receptor tyrosine kinase-like orphan receptor 2 (Ror2) gene. Mice that are homozygous for this allele are viable, fertile, normal in size and do not display any gross physical or…

Investigators

  • Michael E Greenberg

Research Tool

Blmlox Targeted Mutation Mice

These mice possess loxP sites on either side of exon 8 of the targeted gene. Mice that are homozygous for this allele are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. When these mutant mice are…

Investigators

  • Philip Leder

Research Tool

PD-1- Targeted Mutation Mice

PD-1-/-mice lack exons 2-3 of the programmed cell death 1 (Pdcd1) gene. Mice that are homozygous for this allele are viable and fertile. PD-1 is an inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and…

Investigators

  • Arlene H. Sharpe

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