Irit Ben-Chelouche

Director of Business Development, Harvard Medical School

Displaying: 71 - 80 of 80 Results

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Hbva-x Targeted Mutation Mice

Mice that are homozygous for this targeted mutation have an embryonic lethal phenotype. No gene product (mRNA) is detected by Northern blot analysis of homozygous embryos. _-globin mRNA expression is also reduced in homozygous embryos. Homozygous…

Investigators

  • Philip Leder

Research Tool

Thy1-Brainbow 1.1 Transgenic Mice

These Thy1-Brainbow 1.1 (line M) transgenic mice are viable and fertile. The mice possess multiple fluorescent protein sequences uniquely flanked with pairs of incompatible Lox sites alternated to create mutually exclusive recombination events;…

Investigators

  • Jeffrey W. Lichtman

Research Tool

Daxxlox Targeted Mutation Mice

These mice possess loxP sites on either side of exon II (also called exon 3, when the first non-coding exon is included in the numbering scheme) of the targeted gene. Mice that are homozygous for this allele are viable and fertile. Sequence analysis…

Investigators

  • Philip Leder

Research Tool

Lsd1fl Targeted Mutation Mice

These LSD1fl/fl mice possess loxP sites flanking exons 5-6 of the lysine (K)-specific demethylase 1A (Kdm1a) gene. LSD1 demethylates histone H3 on Lys4 or Lys9 (H3K4/K9) and represses hematopoietic stem and progenitor cell (HSPC) gene expression…

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p35 Knock Out Mice

At birth, mice homozygous for this targeted allele are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. Cdk5r protein product is not immunodetectable in homozygote whole-brain lysates. Histological…

Investigators

  • Li-Huei Tsai

Research Tool

Trpa1CKO;pCAGGCre-Er Targeted Mutation Mice

This Trpa1CKO;pCAGGCre-ERTM compound mutant has a floxed allele of the Trpa1 (transient receptor potential cation channel, subfamily A, member 1) gene in addition to a tamoxifen inducible Cre transgene driven by the chicken beta actin…

Investigators

  • David P. Corey

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Ngn1-CreERT2 Transgenic Mice

These transgenic mice have a tamoxifen inducible Cre-mediated recombination system driven by the mouse neurogenin 1, Neurog1, promoter. The transgene insert contains a fusion product involving Cre recombinase and a mutant form of the mouse estrogen…

Investigators

  • Lisa Goodrich

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Thy1-Brainbow 2.1 Transgenic Mice

These Thy1-Brainbow 2.1 (line R) transgenic mice are viable and fertile. The mice possess two invertible DNA segments (four fluorescent protein sequences in total) uniquely positioned in tandem and flanked with LoxP sites to generate a larger number…

Investigators

  • Jeffrey W. Lichtman

Research Tool

EGRPF-Fmn1-IV Trangenic Mice

These mice contain an Enhanced Green Fluorescent Protein (EGFP) gene inserted in-frame into the Fmn1 locus. Expression of the EGFP is detected in the cytoplasm and localized along microtubules. This strain serves as a reporter strain, with EGFP…

Investigators

  • Philip Leder

Research Tool

Cx40 Knock Out Mice

The Gja5 gene encodes an intercellular channel forming protein, also known as Connexin 40, which functions as a component of gap junctions. These mice carry a knock out mutation of the Gja5 gene in which a PGK-NEO cassette replaces the single coding…

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