Vivian Berlin

Executive Director, HMS

Displaying: 61 - 70 of 75 Results

Research Tool

FoxD1GCE eGFPCreERT2 Transgenic Mice

Heterozygous mice are viable and fertile, normal in size and do not display any gross physical or behavioral abnormalities. The DI states that the strain is homozygous lethal. The Foxd1GCE allele expresses an eGFPCreERT2 fusion protein (EGFP and…

Investigators

  • Andrew P. McMahon

Research Tool

Wnt11 knock-out

Mice heterozygous for this targeted mutation are viable and fertile with normal kidney size and histology. Homozygotes exhibit some embryonic lethality and will die by 2 days post partem. While the cause of death is unclear, these neonates have…

Investigators

  • Andrew P. McMahon

Research Tool

Osx1-GFP::Cre Transgenic Mice

Mice hemizygous for this Osx1-GFP::Cre transgene are viable and fertile. The transgene carries both tTA under the regulation of the osterix (Sp7) promoter and, just downstream, a tetracycline responsive element (TRE; tetO)-controlled GFP/Cre fusion…

Investigators

  • Andrew P. McMahon

Research Tool

Cited1-nuc-TagRFP-T Transgenic Mice

These transgenic mice express the Tag-RFPT variant of Red Fluorescent Protein under the direction of the mouse Cited1, Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1, promoter. TagRFP is the optimized monomeric…

Investigators

  • Andrew P. McMahon

Research Tool

Sox2Cre Transgenic Mice

These transgenic mice express Cre recombinase under the control of the mouse SRY-box containing gene 2 promoter. The transgene integrated into an intron of Edil3 (EGF-like repeats and discoidin I-like domains 3). The insertion results in a…

Investigators

  • Andrew P. McMahon

Research Tool

L7Cre Transgenic Mice

Hemizygous mice are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities. Cre activity is observed in parasagittal domains of the cerebellum beginning at embryonic day 17 (E17). At E19, low level…

Investigators

  • Andrew P. McMahon

Research Tool

Wnt7bc3 LoxP Targeted Mutation Mice

Mice homozygous for the Wnt7bc3 allele are viable and fertile, with loxP sites flanking exon 3 of the targeted gene. When bred to mice that express Cre recombinase, the resulting offspring will have this region deleted in the cre-expressing…

Investigators

  • Douglas Melton

Research Tool

Shh Knock Out Mice

Mice homozygous for the Shhtm1Amc targeted mutation display early defects in the establishment and maintenance of midline structures. These defects result from the critical role the Sonic hedgehog (Shh) gene plays in the patterning of vertebrate…

Investigators

  • Andrew P. McMahon

Research Tool

gene trap ROSA 26 Targeted Mutation Mice

These mice contain a sequence encoding an intracellular portion of the mouse Notch1 gene (amino acids 1749-2293), but lacking the c-terminal PEST domain, and Green Fluorescent Protein, GFP, inserted into the GT(ROSA)26Sor locus. Expression of the…

Investigators

  • Douglas Melton

Research Tool

Wnt11-myrTagRFP-IRES-CE Transgenic Mice

These Wnt11-myrTagRFP-IRES-CE mutant mice have a tamoxifen inducible Cre-mediated recombination system and express the Tag-RFPT variant of Red Fluorescent Protein under the direction of the mouse Wnt11, wingless-related MMTV integration site 11,…

Investigators

  • Andrew P. McMahon

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