DBD Search
Vivian Berlin
Executive Director, HMS
Displaying: 61 - 70 of 75 Results
Research Tool
Wnt7bc3 LoxP Targeted Mutation Mice
Mice homozygous for the Wnt7bc3 allele are viable and fertile, with loxP sites flanking exon 3 of the targeted gene. When bred to mice that express Cre recombinase, the resulting offspring will have this region deleted in the cre-expressing…
Investigators
- Douglas Melton
Research Tool
Shh Knock Out Mice
Mice homozygous for the Shhtm1Amc targeted mutation display early defects in the establishment and maintenance of midline structures. These defects result from the critical role the Sonic hedgehog (Shh) gene plays in the patterning of vertebrate…
Investigators
- Andrew P. McMahon
Research Tool
gene trap ROSA 26 Targeted Mutation Mice
These mice contain a sequence encoding an intracellular portion of the mouse Notch1 gene (amino acids 1749-2293), but lacking the c-terminal PEST domain, and Green Fluorescent Protein, GFP, inserted into the GT(ROSA)26Sor locus. Expression of the…
Investigators
- Douglas Melton
Research Tool
Wnt11-myrTagRFP-IRES-CE Transgenic Mice
These Wnt11-myrTagRFP-IRES-CE mutant mice have a tamoxifen inducible Cre-mediated recombination system and express the Tag-RFPT variant of Red Fluorescent Protein under the direction of the mouse Wnt11, wingless-related MMTV integration site 11,…
Investigators
- Andrew P. McMahon
Research Tool
Pax4-cre Transgenic Mice
Pax4-cre transgenic mice have the mouse paired box gene 4 (Pax4) promoter directing expression of an enhanced green fluorescent protein fused to a Tet-off cassette (EGFP/tTA). The transgene also contains a tetracycline-responsive element with a CMV…
Investigators
- Douglas Melton
Research Tool
Cldn6CIHV Targeted Mutation Mice
In this strain, the Cldn6CIHV allele replaces the entire coding region of the claudin 6 (Cldn6) locus with a CreERT2 fusion protein, an internal ribosome entry site (IRES), and a histone H2B-Venus fluorescent protein. This abolishes gene expression.…
Investigators
- Douglas Melton
Research Tool
Sox2-cre Transgenic Mice
The Sox2Cre transgene was designed with 12.5 kb of upstream regulatory sequence from the mouse Sox2 locus (SRY-box containing gene 2), a chicken _-actin intron, a Cre recombinase gene, and a rabbit _-globin poly(A) sequence. This transgene was…
Investigators
- Andrew P. McMahon
Research Tool
Lfng-nuc-Tag-RFP-T-IRES-CE Transgenic Mice
These Lfng-nuc-Tag-RFP-T-IRES-CE mutant mice have a tamoxifen inducible Cre-mediated recombination system and express the Tag-RFPT variant of Red Fluorescent Protein under the direction of the mouse Lfng, LFNG O-fucosylpeptide…
Investigators
- Andrew P. McMahon
Research Tool
Wnt9bc LoxP Targeted Mutation Mice
Mice homozygous for the Wnt9bc allele are viable and fertile, with loxP sites flanking exon 2 of the targeted gene. When bred to mice that express Cre recombinase, the resulting offspring will have this region deleted in the cre-expressing…
Investigators
- Andrew P. McMahon
Research Tool
Shh Targeted Mutation Mice
Mice that are homozygous for the Shhtm2Amc targeted mutation are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. This conditional mutant contains two loxP sites flanking exon 2 of the targeted…
Investigators
- Andrew P. McMahon