Homozygous Hba-a1 (hemoglobin alpha, adult chain 1) knockout mice (129S-Hba-a1tm1Led/J) were developed by HHMI Investigator Dr. Philip Leder and his lab at Harvard Medical School. While the mice are viable and fertile, they develop anemia with elevated platelet number and decreased hemoglobin levels (Blood, 1997).
The detailed description of the mouse strain can be found here.
The mice can be used to model the following conditions:
- Erythropoiesis and hemoglobin defects
The mouse strain is available for licensing from Harvard University and will be provided by The Jackson Laboratory.