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DNA Destruction Through Novel and Adaptable Enzymes

Bacteria in mixed populations compete for resources and have several strategies on surviving and dominating other bacterial species. One method employs the injection of lethal effectors into adjacent cells. These effectors can disrupt cell membranes…


  • Karine Gibbs

Disinfecting Pathogens on Surfaces and in Air

Pathogens found in the air and on surfaces present a massive global health challenge, threating human health and food security. The lab of Philip Demokritou at Harvard’s T.H. Chan School of Public Health has developed Engineered Water Nanostructures…


  • Philip Demokritou

Isolating live cells after high-throughput, long-term, time-lapse microscopy

Researchers led by Johan Paulsson have engineered a high-throughput microfluidic device for multigenerational culturing, imaging, and tracking of single-cell lineages. The platform is highly customizable and is compatible with many cell types,…


  • Johan Paulsson

Extracellular vesicles for COVID-19 vaccine development

The laboratory of Quan Lu at the Harvard T.H. Chan School of Public Health has developed an innovative vaccine platform that features a novel antigen display technology that has been shown to elicit broadly neutralizing antibody responses from…


  • Quan Lu

Red blood cell-hitchhiking to boost delivery of antivirals and immunotherapies to the lungs

Researchers in Samir Mitragotri’s lab have developed a way to traffic therapeutics directly to the lungs following routine intravenous injection and hope to apply the technology to treatment of acute respiratory distress syndrome (ARDS) and…


  • Samir Mitragotri

Ionic liquid aerosols for respiratory complications related to COVID-19

Researchers in the lab of Samir Mitragotri have developed ionic liquid aerosols that have the potential to combat pulmonary bacterial infections. The technology may help to treat the respiratory conditions resulting from COVID-19 infection and…


  • Samir Mitragotri

Repurposing of therapeutics to block SARS-CoV-2 protease activity and pathogenesis

Researchers in Christina Woo’s lab are studying the essential mechanisms by which SARS-CoV-2 (novel coronavirus) co-opts normal cellular processes for viral replication. One mechanism that the team has identified indicates that the virus encodes…


  • Christina Woo

Utilizing the herpes simplex virus-based vaccine vectors to develop a COVID-19 vaccine

Researchers in the lab of David Knipe have constructed the HSV-1 based vaccine vector HSV-1 d106S. The vector can express viral, bacterial, or cancer gene products and has been used to induce protective immunity in humanized mice against HIV and…


  • David Knipe

Compounds that block human cytomegalovirus by targeting the nuclear egress complex

Researchers in Dr. Donald Coen’s lab have identified molecules that inhibit human cytomegalovirus (HCMV) virion egress from the cell, effectively inhibiting HCMV replication. The team is looking to expand on these findings in collaborations that…


  • Donald Coen

Promising new hand disinfection technology to eliminate pathogens

Pathogens found in the air and on surfaces present a massive global health challenge, threating human health and food security. With the increased prevalence of antibiotic-resistant bacteria and the use of harmful chemicals in typical…


  • Philip Demokritou
  • Georgios Pyrgiotakis
  • Joseph Brain
  • Nachiket Vaze
  • Mary Eleftheriadou

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