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Displaying: 41 - 50 of 103 Results
Selective deposition of cells in microwells
This invention is a method of selectively functionalizing indentations (such as wells or channels in microfluidic systems) or protrusions on a substrate such that, for example, cells selectively bind to the indentations or the protrusions. The…
DBD
- Sam Liss
Investigators
- George Whitesides
- Emanuele Ostuni
- Christopher Chen
- Donald Ingber
Directed evolution of proteins and nucleic acids using nonhomologous random recombination
The nonhomologous random recombination (NRR) method allows portions of nucleic acids to be recombined at sites where there is little or no sequence homology. This increases the frequency at which novel sequences are generated, allowing a more…
DBD
- Irit Ben-Chelouche
Investigators
- David Liu
- Joshua Bittker
Absolute quantification of Proteins (AQUA)
This invention provides methods, reagents and kits for obtaining absolute quantification of proteins and their modifications directly from cell lysates. In particular, the invention provides peptide internal standards for use in high performance…
DBD
- Grant Zimmermann
Investigators
- Steven Gygi
- Scott Gerber
MicroArray spot LINEar regression (MASLINER) software
Signal intensities between samples on a microarrary typically vary by as much as three to four orders of magnitude, frustrating efforts at comparative analysis of samples assayed in parallel. At any given laser power or photomultiplier tube gain…
DBD
- Maryanne Fenerjian
Investigators
- George Church
- John Aach
- Aimee Dudley
- Martin Steffen
Lead compounds for the treatment of pain
The invention is a novel synthetic pathway to the generation of nonpeptidic ligands for the mu opioid class of G-protein coupled receptors. The system uses stereochemical variation and acyclic geometric stereocontrol to generate diversity among its…
DBD
- Vivian Berlin
Investigators
- Gregory Verdine
- Bryce Harrison
- Tiffany Gierasch
- Zhangjie Shi
Modulating gene activity on chondrocytes
Transgenic mice were generated in which the regulatory sequences for the Col2a1 gene were used to drive expression of Cre recombinase in chondrocytes. The strain initiates Cre-mediated recombination predominantly in immature chondrocytes and the…
DBD
- Vivian Berlin
Investigators
- Andrew McMahon
- Fanxin Long
Drug-inducible RNA aptaswitch for regulating eukaryotic protein expression
Using in vivo evolution techniques, scientists in the Liu laboratory have engineered a drug-inducible aptaswitch for regulating eukaryotic protein expression at the transcription level. This aptaswitch consists of two modular RNA elements: a…
DBD
- Irit Ben-Chelouche
Investigators
- David Liu
- Allen Buskirk
- Polina Kehayova
Animal model of diabetes and obesity
Mice with the JNK 1 and JNK2 genes knocked out were crossed with the obese mouse line (ob/ob) to create a mouse model of diabetes and obesity. These mice exhibit many of the hallmark metabolic pertubations characteristic in diabetes and obesity.
DBD
- Vivian Berlin
Investigators
- Gokhan Hotamisligil
- Michael Karin
Monoclonal IgE anti-ovalbumin antibody
A laboratory from the Harvard School of Public Health has developed a monoclonal Ig E mouse anti-ovalbumin. This antibody is useful as a positive control in ELISA assays used to measure the level of IgE anti-ovalbumin antibodies in mouse models of…
DBD
- Grant Zimmermann
Investigators
- Lester Kobzik
- Aiyappa Palecanda
Bead-based polymerase colony microarrays and nucleic acid sequencing ("Polony-FISSEQ Beads")
Foundational work of Dr. George Church has enabled the production and use of replicable arrays of polymerase-amplified nucleic acid colonies (so-called "polonies") on semisolid support matrices (see Harvard Case #1438). The present invention extends…
DBD
- Maryanne Fenerjian
Investigators
- George Church
- Jay Shendure
- Gregory Porreca
- Jun Zhu