Targeting spiral ganglion neurons for treatment of hearing loss

Hearing loss makes interactions with the world challenging for over 30 million people in the United States. While cochlear implants and hearing aid devices can ameliorate hearing loss, they often fail to restore the function of spiral ganglion neurons (SGNs) that transmit electrical stimuli from the hair cells to the brain.

Using genetic tools, advanced imaging and screening techniques, as well as unique animal models, Dr. Lisa Goodrich of Harvard Medical School has identified druggable targets for repair and development of spiral ganglion neurons. Several research projects aimed at better understanding of SNG physiology and identification of novel therapeutics targeting SNGs are available for a collaborative research program with the Goodrich lab.