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Displaying: 111 - 120 of 139 Results

B6(D2)-Tg(CAG-Brainbow1.0)3 Transgenic Mice

These transgenic mice carry the Brainbow 1.0 cassette, incorporating dTomato, mCerulean, and EYFP, driven by the broadly-expressed CAG (CMV-chicken beta actin) promoter. These fluorescent markers are useful in tracing cell lineage. This strain, line…

DBD

  • Vivian Berlin

Investigators

  • Kevin Eggan

PD-1- Targeted Mutation Mice

PD-1-/-mice lack exons 2-3 of the programmed cell death 1 (Pdcd1) gene. Mice that are homozygous for this allele are viable and fertile. PD-1 is an inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and…

DBD

  • Irit Ben-Chelouche

Investigators

  • Arlene Sharpe

Tg(Gnrh1-cre)1 Transgenic Mice

Neurons that synthesize and secrete Gnrh1 (gonadotropin releasing hormone 1; also known as Lhrh) integrate and control peripheral and central aspects of reproduction, including the onset of puberty. The hormone is produced by a small and diffuse…

DBD

  • Yelena Bisharyan

Trpc2 Knock Out Mice

In mouse, the Trpc2 (transient receptor potential cation channel, subfamily C, member 2) gene is expressed primarily in the neurons of the vomeronasal organ (VNO). It is involved with processes of pheromone detection which impact social behaviors.…

DBD

  • Yelena Bisharyan

Tg(Thy1-Brainbow3.1) Transgenic Mice

The Thy1-Brainbow 3.1 transgene was designed by Drs. Dawen Cai and Joshua R.Sanes (Harvard University) with the mouse Thy1 (thymus cell antigen 1, theta) regulatory elements surrounding four fluorescent protein (Yellow fluorescent protein…

DBD

  • Yelena Bisharyan

Investigators

  • Joshua Sanes
  • Joshua Sanes

Uba6flox/flox Targeted Mutation Mice

These Uba6flox/flox mutant mice possess loxP sites flanking exons 16-17 of the ubiquitin-like modifier activating enzyme 6 (Uba6) gene. Uba6 (E1) is part of the ubiquitin proteasome system (UPS) which regulates protein homeostasis during…

DBD

  • Vivian Berlin

CD1-deficient BXSB.Yaa Knock Out Mice

BXSB.Yaa CD1-/- (BXSB.Yaa Cd1d1/Cd1d2-/-) mice are a BXSB-congenic strain carrying a null mutation of the CD1 antigen complex; both CD1.1 (Cd1d1) and CD1.2 (Cd1d2) expression is abolished. Homozygous (CD1-/-) mice are natural killer T cell…

DBD

  • Irit Ben-Chelouche

Investigators

  • Michael Grusby

Prg4GFPCreERt2 Transgenic Mice

The Prg4, proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein), gene encodes the lubricin protein, a large proteoglycan that acts as a lubricant at the surface of cartilage of articulating joints. Prg4 also encodes…

DBD

  • Grant Zimmermann

Brsk1Knock Out Mice

The protein encoded by Brsk1 is a serine/threonine-protein kinase that is involved in neuronal polarization, axon branching, and presynaptic differentiation in diverse neuronal populations. These mice carry a targeted mutation of the Brsk1 gene in…

DBD

  • Yelena Bisharyan

Investigators

  • Joshua Sanes
  • Joshua Sanes

Brsk2Floxed Transgenic Mice

The protein encoded by Brsk2 is a serine/threonine-protein kinase that is involved in neuronal polarization, axon specification, axon branching, and presynaptic differentiation in diverse neuronal populations. These mice possess loxP sites on either…

DBD

  • Yelena Bisharyan

Investigators

  • Joshua Sanes
  • Joshua Sanes

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