Browse Research Tools
Browse Research Tools
Research Tools Keyword Search
Search Results
Displaying: 121 - 130 of 139 Results
Stim2 flox Transgenic Mice
The targeted Stim2 gene encodes a protein involved in regulation of cytosolic and endoplasmic reticulum calcium levels and store-operated calcium channels. These Stim2fl mice possess loxP sites on either side of exon 3 of the targeted gene. Exon 3…
Orai1 Knock Out Mice
The targeted Orai1 gene encodes a pore subunit of the store-operated calcium channel, CRAC (calcium release-activated calcium) channel. Mutations in this gene have been associated with primary immunodeficiency-9 and tubular aggregate myopathy-2.…
Slamf2 Knock Out Mice
The Cd48 gene, also know as Slamf2 (signaling lymphocytic activation molecule 2), encodes for a lymphocyte cell surface antigen that binds CD2 and CD244 and is involved in regulation of T cell activation. These mice carry a targeted mutation for…
DBD
- Irit Ben-Chelouche
Investigators
- Arlene Sharpe
Hist2h2be Targeted Mutation Mice
Hist2h2be (histone cluster 2, H2be) is expressed exclusively in olfactory chemosensory neurons. Expression is reduced by sensory activity, and it alters gene expression and promotes neuronal cell death in mature olfactory sensory neurons,…
DBD
- Yelena Bisharyan
Hist2h2be Flag-Tagged Transgenic Mice
Hist2h2be (histone cluster 2, H2be) is expressed exclusively in olfactory chemosensory neurons. Expression is reduced by sensory activity, and it alters gene expression and promotes neuronal cell death in mature olfactory sensory neurons,…
DBD
- Yelena Bisharyan
Lsd1fl Targeted Mutation Mice
These LSD1fl/fl mice possess loxP sites flanking exons 5-6 of the lysine (K)-specific demethylase 1A (Kdm1a) gene. LSD1 demethylates histone H3 on Lys4 or Lys9 (H3K4/K9) and represses hematopoietic stem and progenitor cell (HSPC) gene expression…
DBD
- Irit Ben-Chelouche
Ppp3ca Knock Out Mice
Ppp3ca (protein phosphatase 3, catalytic subunit, alpha isoform) is a calcium- and calmodulin-dependent serine/threonine protein phosphatase. It is an important signaling molecule in T cells, neurons, the heart, and kidneys. The catalytic domain of…
DBD
- Grant Zimmermann
Ihhfl Targeted Mutation Mice
These Ihhfl/fl mutant mice possess loxP sites flanking exon 1 of the Indian hedgehog (Ihh) gene. IHH is involved in growth plate maintenance and sustaining trabecular bone after birth. It is also essential for chondrocyte proliferation and…
Tbet-cre Transgenic Mice
These transgenic mice express Cre recombinase from the mouse Tbx21 (T-box 21; also called Tbet) promoter in mitral cells of the main and accessory olfactory bulbs. Surveys of the rest of the brain show that Cre-induced recombination is specific to…
DBD
- Yelena Bisharyan
tetO-Gata6 Transgenic Mice
Gata6 Tg mice express GATA binding protein 6 (Gata6) cDNA under control of a tetracycline operator (tetO). Hemizygotes are viable and fertile. GATA6 is a zinc-finger-containing transcription factor involved in the regulation of early axial…
DBD
- Grant Zimmermann