DBD Search
Yelena Bisharyan
Director of Business Development
Displaying: 11 - 20 of 31 Results
Invention
Photostick: Physical isolation of single cells from tissue, for further propagation and single cell sequencing and omics
Photostick enables the physical selection of single cells from large populations in diverse environments. The novel process entails photochemical immobilization of live cells with patterned illumination, followed by removal of unwanted cells with…
Investigators
- Adam Ezra Cohen
- Miao-Ping Chien
Invention
Early-life nutrition additives to protect against inflammatory bowel disease
The Kasper lab has identified membrane glycosphingolipids from the commensal bacterium Bacteroides fragilis that reduce colonic invariant natural killer T (iNKT) cells – important contributors of inflammatory bowel disease pathogenesis. Exposure to…
Investigators
- Dennis Kasper
Invention
Transgenic mice with fluorescently tagged neuronal mitochondria as a new tool to study axonal transport
Homozygous transgenic mouse stain B6.Cg-Tg(Thy1-CFP/COX8A)S2Lich/J (also know as Thy-CFP-MitoS) was developed by Dr. Jeffrey W. Lichtman at Harvard University. The mice express mitochondria-targeting Cyan Fluorescent Protein (CFP) in neuronal cell…
Investigators
- Jeffrey W. Lichtman
- Florence M. Bareyre
- Thomas Misgeld
- Martin Kerschensteiner
Invention
Corticospinal tract (CST)-YFP transgenic mice for monitoring axonal responses to spinal cord injury
Hemizygous transgenic mouse strain B6.Cg-Tg(Thy1-EYFP)15Jrs/J (also known as Thy-STOP-YFP) was developed by Dr. Joshua R. Sanes at Harvard University. The mouse strain harbors an Enhanced Yellow Fluorescent Protein (EYFP) controlled by mouse thymus…
Investigators
- Joshua R. Sanes
- Joshua R. Sanes
- Florence M. Bareyre
Invention
Trioxacarcins and analogs: DNA-modifying compounds with potent anti-proliferative effects
The trioxacarcins are a new class of DNA-modifying natural products with potent antiproliferative effects (with subnanmolar IC70 values against lung, mammary, and CNS cancer cell lines). Trioxacarcin A, B, and C were first discovered and isolated…
Investigators
- Andrew G. Myers
- Jakub Svenda
- Nicholas Hill
- Robert Yu
- Daniel J. Smaltz
- Thomas Magauer
Research Tool
spH64 Thy1 Transgenic Mice
These transgenic mice express spH, the pH-sensitive variant of the enhanced green fluorescent protein (ecliptic pHluorin) fused to the mouse synaptic vesicle-associated membrane protein 2 (Vamp2), under the control of the mouse thymus cell antigen 1…
Investigators
- Venkatesh Murthy
Research Tool
Vmn1r50/Tau-LacZ Transgenic Mice
Vmn1r50 (vomeronasal 1 receptor 50; also called VN2) is a member of the vomeronasal organ V1R gene family, whose activation is believed to be involved with pheromone detection. These mice co-express tau-lacZ with pheromone receptor Vmn1r50, enabling…
Research Tool
Hist2h2be Flag-Tagged Transgenic Mice
Hist2h2be (histone cluster 2, H2be) is expressed exclusively in olfactory chemosensory neurons. Expression is reduced by sensory activity, and it alters gene expression and promotes neuronal cell death in mature olfactory sensory neurons,…
Research Tool
Tg(Gnrh1-cre)1 Transgenic Mice
Neurons that synthesize and secrete Gnrh1 (gonadotropin releasing hormone 1; also known as Lhrh) integrate and control peripheral and central aspects of reproduction, including the onset of puberty. The hormone is produced by a small and diffuse…
Research Tool
Tbet-cre Transgenic Mice
These transgenic mice express Cre recombinase from the mouse Tbx21 (T-box 21; also called Tbet) promoter in mitral cells of the main and accessory olfactory bulbs. Surveys of the rest of the brain show that Cre-induced recombination is specific to…