DBD Search
Yelena Bisharyan
Director of Business Development
Displaying: 11 - 20 of 31 Results
Invention
Trioxacarcins and analogs: DNA-modifying compounds with potent anti-proliferative effects
The trioxacarcins are a new class of DNA-modifying natural products with potent antiproliferative effects (with subnanmolar IC70 values against lung, mammary, and CNS cancer cell lines). Trioxacarcin A, B, and C were first discovered and isolated…
Investigators
- Andrew G. Myers
- Jakub Svenda
- Nicholas Hill
- Robert Yu
- Daniel J. Smaltz
- Thomas Magauer
Invention
Transgenic mice with fluorescently tagged neuronal mitochondria as a new tool to study axonal transport
Homozygous transgenic mouse stain B6.Cg-Tg(Thy1-CFP/COX8A)S2Lich/J (also know as Thy-CFP-MitoS) was developed by Dr. Jeffrey W. Lichtman at Harvard University. The mice express mitochondria-targeting Cyan Fluorescent Protein (CFP) in neuronal cell…
Investigators
- Jeffrey W. Lichtman
- Florence M. Bareyre
- Thomas Misgeld
- Martin Kerschensteiner
Invention
Corticospinal tract (CST)-YFP transgenic mice for monitoring axonal responses to spinal cord injury
Hemizygous transgenic mouse strain B6.Cg-Tg(Thy1-EYFP)15Jrs/J (also known as Thy-STOP-YFP) was developed by Dr. Joshua R. Sanes at Harvard University. The mouse strain harbors an Enhanced Yellow Fluorescent Protein (EYFP) controlled by mouse thymus…
Investigators
- Joshua R. Sanes
- Joshua R. Sanes
- Florence M. Bareyre
Research Tool
spH Trangenic Mice
These transgenic mice express spH, the pH-sensitive variant of the green fluorescent protein (superecliptic pHluorin) fused to the mouse synaptic vesicle-associated membrane protein 2 (Vamp2), under the control of the mouse thymus cell antigen 1…
Investigators
- Venkatesh Murthy
Research Tool
Vmn1r206/YFP Transgenic Mice
Vmn1r206 (vomeronasal 1 receptor 206; also called V1Rh7) is a member of the vomeronasal organ V1R gene family, whose activation is believed to be involved with pheromone detection. Inputs from neurons expressing closely related V1Rs intermingle…
Research Tool
spH64 Thy1 Transgenic Mice
These transgenic mice express spH, the pH-sensitive variant of the enhanced green fluorescent protein (ecliptic pHluorin) fused to the mouse synaptic vesicle-associated membrane protein 2 (Vamp2), under the control of the mouse thymus cell antigen 1…
Investigators
- Venkatesh Murthy
Research Tool
Vmn1r191/CFP Transgenic Mice
Vmn1r191 (vomeronasal 1 receptor 191; also called V1Rh15) is a member of the vomeronasal organ V1R gene family, whose activation is believed to be involved with pheromone detection. Inputs from neurons expressing closely related V1Rs intermingle…
Research Tool
Tg(Gnrh1-cre)1 Transgenic Mice
Neurons that synthesize and secrete Gnrh1 (gonadotropin releasing hormone 1; also known as Lhrh) integrate and control peripheral and central aspects of reproduction, including the onset of puberty. The hormone is produced by a small and diffuse…
Research Tool
Vmn1r51/Tau-LacZ Transgenic Mice
Vmn1r51 (vomeronasal 1 receptor 51; also called VN12) is a member of the vomeronasal organ V1R gene family, whose activation is believed to be involved with pheromone detection. These mice co-express tau-lacZ with pheromone receptor Vmn1r51…
Research Tool
Trpc2 Knock Out Mice
In mouse, the Trpc2 (transient receptor potential cation channel, subfamily C, member 2) gene is expressed primarily in the neurons of the vomeronasal organ (VNO). It is involved with processes of pheromone detection which impact social behaviors.…