DBD Search
Irit Ben-Chelouche
Director of Business Development, Harvard Medical School
Displaying: 31 - 40 of 80 Results
Invention
Drug-inducible RNA aptaswitch for regulating eukaryotic protein expression
Using in vivo evolution techniques, scientists in the Liu laboratory have engineered a drug-inducible aptaswitch for regulating eukaryotic protein expression at the transcription level. This aptaswitch consists of two modular RNA elements: a…
Investigators
- David R. Liu
- Allen R. Buskirk
- Polina Kehayova
Invention
Bisphosphonates as novel adjuvants to enhance the adaptive immune response, validated with common types of vaccine antigens and commercial vaccines
Despite decades of adjuvant research, only a handful of adjuvants have been approved in seven major global markets and only two (Alum and GSK’s AS04) are licensed in the US. The availability of additional adjuvants has been minimized due to…
Investigators
- Ulrich H. von Andrian
- Matteo Iannacone
- Elena Tonti
- Elliott Ashley Moseman
Invention
Small-molecule-triggered intein splicing as a universal switch for protein activation
Researchers in the laboratory of Professor David Liu have used directed evolution techniques to evolve an intein-based molecular switch that transduces binding of a small molecule into the activation of an arbitrary protein of interest. To create…
Investigators
- David R. Liu
- Allen R. Buskirk
- Sun H. Peck
Invention
Novel methods for generating regulatory T-cells
Regulatory T-cells (Tregs) are key mediators of peripheral tolerance that can actively suppress effector T-cells, inhibit inflammation and mediate self-tolerance. Unlike naturally occurring Tregs (nTregs) which develop in the thymus,…
Investigators
- Arlene H. Sharpe
- Loise Francisco
- Vijay K. Kuchroo
Invention
New therapeutic pathway for autoimmune and inflammatory disorders
A recently-discovered class of T cells - T follicular regulatory (TFR) cells - controls the production of antibodies. TFR cells inhibit T follicular helper (TFH) cells, which mediate antibody production in lymph nodes. Several autoimmune diseases…
Investigators
- Arlene H. Sharpe
- Peter Sage
- Loise Francisco
Invention
A system for the continuous directed evolution of biomolecules
Researchers in the laboratory of Professor David Liu have developed a platform that enables the continuous directed evolution of gene-encoded molecules that can be linked to protein production in E. coli. During phage-assisted continuous evolution…
Investigators
- David R. Liu
- Kevin M. Esvelt
- Jacob Carlson
- Ahmed Hussein Badran
Invention
Interaction-dependent PCR: Multiplexed identification of ligand-target pairs from DNA-encoded ligand/target libraries in a single solution-phase experiment
IDPCR is based on the melting temperature difference between duplex DNA formed intramolecularly versus intermolecularly. Binding of a target to its ligand would increase the effective molarity of single-stranded DNA oligonucleotides linked to the…
Investigators
- David R. Liu
- David J. Gorin
- Adam S. Kamlet
- Lynn McGregor
- Christoph E. Dumelin
Invention
Fzd2 - novel anti-cancer therapeutic target
The role of β-catenin accumulation in the development of tumorigenicity has been well documented to date, with various mutations in β-catenin, APC, and axin genes typically to blame. Although β-catenin accumulation plays a role in hepatocellular…
Investigators
- Gavin MacBeath
- Taran S. Gujral
Invention
Small molecule inhibitors of Ebola virus entry
Background: Human cells that are susceptible to infection by pathogenic viruses express surface membrane proteins that mediate attachment and membrane fusion activity of virus glycoproteins. There are strong structural and functional similarities…
Investigators
- Dennis Kasper
- Kyungae Lee
- Tao Ren
- James Cunningham
- Kartik Chandran
Invention
SPECT diagnostic agents for Parkinson’s Disease and ADHD
The Harvard research team has over two decades of experience in the design and synthesis of molecules that target monoamine uptake potently and selectively. The class of compounds utilized for the design of the subject SPECT agents is the…
Investigators
- Bertha Madras
- Paul Blundell
- Alan J. Fischman
- Peter Meltzer
- Alun G. Jones
- Ashfaq Mahmood