DBD Search
Irit Ben-Chelouche
Director of Business Development, Harvard Medical School
Displaying: 41 - 50 of 80 Results
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Trpa1CKO;pCAGGCre-Er Targeted Mutation Mice
This Trpa1CKO;pCAGGCre-ERTM compound mutant has a floxed allele of the Trpa1 (transient receptor potential cation channel, subfamily A, member 1) gene in addition to a tamoxifen inducible Cre transgene driven by the chicken beta actin…
Investigators
- David P. Corey
Research Tool
Ngn1-CreERT2 Transgenic Mice
These transgenic mice have a tamoxifen inducible Cre-mediated recombination system driven by the mouse neurogenin 1, Neurog1, promoter. The transgene insert contains a fusion product involving Cre recombinase and a mutant form of the mouse estrogen…
Investigators
- Lisa Goodrich
Research Tool
Thy1-Brainbow 2.1 Transgenic Mice
These Thy1-Brainbow 2.1 (line R) transgenic mice are viable and fertile. The mice possess two invertible DNA segments (four fluorescent protein sequences in total) uniquely positioned in tandem and flanked with LoxP sites to generate a larger number…
Investigators
- Jeffrey W. Lichtman
Research Tool
EGRPF-Fmn1-IV Trangenic Mice
These mice contain an Enhanced Green Fluorescent Protein (EGFP) gene inserted in-frame into the Fmn1 locus. Expression of the EGFP is detected in the cytoplasm and localized along microtubules. This strain serves as a reporter strain, with EGFP…
Investigators
- Philip Leder
Research Tool
Cx40 Knock Out Mice
The Gja5 gene encodes an intercellular channel forming protein, also known as Connexin 40, which functions as a component of gap junctions. These mice carry a knock out mutation of the Gja5 gene in which a PGK-NEO cassette replaces the single coding…
Research Tool
PD-L1 Knock Out Mice
The signal and all of the immunoglobulin (Ig)-V-like exon of the CD274 antigen (Cd274) gene were replaced with a neomycin resistance cassette, abolishing PD-L1 gene expression. PD-L1 is one of two ligands for PD-1 and is upregulated on antigen…
Investigators
- Arlene H. Sharpe
Research Tool
R26R-Confetti Targeted Mutation Mice
Mice homozygous for the R26R-Confetti conditional allele are viable and fertile, with a CAG promoter, loxP site, and STOP cassette preventing transcription of the downstream Brainbow 2.1 sequences. The Brainbow 2.1 region contains two loxP-flanked…
Investigators
- Jeffrey W. Lichtman
Research Tool
Truncated Ab1TL Transgenic Mice
Hemizygous transgenic mice expressing only truncated class II A beta molecules lacking the 13 membrane distal residues were generated to address the role of class II cytoplasmic domains in physiological, non-transformed APC and in vivo immune…
Investigators
- Michael J. Grusby
Research Tool
NOD.DQ6, H2-Ab0null,Rag1null
Rag1 and H2-Ab1 deficient NOD mice carrying transgenes encoding humanized CD4 and HLA-DQ6 lack T and B cells and are free of autoimmune diabetes and cardiomyopathy, and do not develop thyroiditis. This model is useful in adoptive transfer…
Investigators
- Michael J. Grusby
Research Tool
Thy1-Brainbow Transgenic Mice
These Thy1-Brainbow 1.0 (line H) transgenic mice are viable and fertile. The mice possess multiple fluorescent protein sequences uniquely flanked with pairs of incompatible Lox sites alternated to create mutually exclusive recombination events;…
Investigators
- Jeffrey W. Lichtman