DBD Search
Vivian Berlin
Executive Director, HMS
Displaying: 21 - 30 of 75 Results
Invention
A transgenic reporter system can be used for recombination-mediated modulation of gene activity in the developing mouse embryo
A transgenic reporter system consisting of a tamoxifen-inducible form of Cre recombinase (Cre-ERTM) that can be used for recombination-mediated modulation of gene activity in the developing mouse embryo. Using the enhancer of the Wnt1 gene to…
Investigators
- Andrew P. McMahon
- Paul S. Danielian
- David H. Rowitch
Invention
Cell-based assay for the discovery of glycogen synthase kinase inhibitors
This cell-based assay is applicable to diverse biological systems for discovery of glycogen synthase kinase inhibitors. The inhibition of GSK-3b has dramatic morphogenic effects during the early development of numerous organisms, including humans,…
Investigators
- Douglas Melton
- Peter S. Klein
Research Tool
Ihh Knock Out Mice
Mice that are heterozygous for the targeted allele are viable and fertile. Mice homozygous for this mutation have a lethal phenotype. Half of homozygous null mice have an embryonic lethal phenotype, dying between 10.5 to 12.5 days post coitum. The…
Investigators
- Andrew P. McMahon
Research Tool
Wnt4 Knock Out Mice
Mice that are heterozygous for the targeted mutation are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. Homozygous null mice have a perinatal lethal phenotype and die within 24 hours of birth.…
Investigators
- Andrew P. McMahon
Research Tool
Rosa26-rtTA::Col1a1-tetO-H2B-mCherry Targeted Mutation Mice
The Rosa26-rtTA::Col1a1-tetO-H2B-mCherry double mutant mice were generated by breeding Rosa26-rtTA mice (from Stock No. 006965) with Col1a1-tetO-H2B-mCherry mice (from Stock No. 014592). The Rosa26-rtTA targeted mutation has an optimized form of…
Investigators
- Kevin Carl Eggan
Research Tool
Dhh Knock Out mice
Mice that are homozygous for the targeted mutation are viable, normal in size and do not display any gross physical or behavioral abnormalities. Homozygous male mice are sterile due to arrested spermatogenesis at the late meiosis, primary…
Investigators
- Andrew P. McMahon
Research Tool
Tshz3-GC eGFPCre Transgemic Mice
These transgenic mice express the eGFPCre (Enhanced Green Fluorescent Protein and Cre recombinase), GC, fusion gene under the direction of the mouse Tshz3, teashirt zinc finger family member 3, promoter. GFP fluorescence is detected in smooth muscle…
Investigators
- Andrew P. McMahon
Research Tool
Ngn3/CreER Trangenic Mice
These transgenic mice have a tamoxifen inducible Cre-mediated recombination system driven by the mouse neurogenin 3, Neurog3, promoter. The transgene insert contains a fusion product involving Cre recombinase and a mutant form of the mouse estrogen…
Investigators
- Douglas Melton
Research Tool
B6(D2)-Tg(CAG-Brainbow1.0)3 Transgenic Mice
These transgenic mice carry the Brainbow 1.0 cassette, incorporating dTomato, mCerulean, and EYFP, driven by the broadly-expressed CAG (CMV-chicken beta actin) promoter. These fluorescent markers are useful in tracing cell lineage. This strain, line…
Investigators
- Kevin Carl Eggan
Research Tool
Six2-GCE Targeted Mutation Mice
While heterozygous mice are viable and fertile with no reported abnormalities, homozygous mice die shortly after birth. The Six2GCE "knock-in" allele both abolishes Six2 gene function and expresses an eGFPCreERT2 fusion protein (EGFP and creERT2…
Investigators
- Andrew P. McMahon