Vivian Berlin

Executive Director, HMS

Displaying: 21 - 30 of 75 Results

Invention

Using (-)-indolactam V to induce differentiation of human and mouse embryonic stem cells into pancreatic lineage

• ILV can be used alone, or in combination with growth factors, to direct differentiation of ESCs into pancreatic specification. ILV is effective on human ESC lines and mouse ESC lines. • ILV is effective on human ESC lines HUES 2, 4 and 8. After 4…

Investigators

  • Douglas Melton
  • Shuibing Chen
  • Malgorzata Borowiak
  • Julia L. Fox
  • Stuart L. Schreiber
  • Lee F. Peng
  • Lee L. Rubin
  • Kelvin Lam
  • Lance Davidow

Invention

A drug discovery platform using novel labeled uridine analogs contribute to molecular biology research

This invention consists of novel 5-amino deoxyribouridine analogs. The analogs are labeled with a radioactive or fluorescent moiety and incorporated into nucleic acid by PCR for use in genomic research applications. One assay design involves a…

Investigators

  • Gregory L. Verdine
  • Michael J. Storek

Research Tool

Irf8 Knock Out Mice

Mice homozygous for this Irf8 knockout allele (Irf8-/-) may be expected to to exhibit some or all of the phenotype published for other Irf8 null mutations on both a C57BL/6J-congenic and mixed genetic background. For example, other Ifr8 null mice…

Investigators

  • Andrew P. McMahon

Research Tool

Wnt7a Knock Out Mice

Mice that are homozygous for the targeted mutation are viable, but sterile. A truncated mRNA transcript is detected during embryogenesis. Homozygotes exhibit ventralization of dorsal limb mesoderm tissues. The variable phenotype includes thickening…

Investigators

  • Andrew P. McMahon

Research Tool

RosaGli3TFlag c/c Transgenic Mice

These RosaGli3TFlag c/c mice contain a floxed-neomycin resistance (neo) cassette and polyadenylation signal, cDNA encoding a FLAG-tagged GLI-Kruppel family member (Gli3) repressor gene, an internal ribosome entry site (IRES), and a Venus yellow…

Investigators

  • Andrew P. McMahon

Research Tool

FoxD1GC Transgenic Mice

Heterozygous mice are viable and fertile, normal in size and do not display any gross physical or behavioral abnormalities. The DI states that the strain is homozygous lethal. The FoxD1GC allele expresses an eGFPCre fusion protein (EGFP and cre…

Investigators

  • Andrew P. McMahon

Research Tool

Wnt-1/GAL4/cre-11 Trangenic Mice

When homozygous for both co-injected transgenes, Wnt-1/GAL4/cre-11 transgenic mice are viable and fertile. Of note for Wnt-1/GAL4/cre-11 transgenic mice on the original mixed genetic background, the donating investigator (Dr. Epstein) reported that…

Investigators

  • Andrew P. McMahon

Research Tool

Osr1GCE Knock In Mice

Homozygous mice die upon birth with multiple abnormalities of the heart and urogenital system (among other tissues). Heterozygous mice are viable and fertile. The Osr1eGFPCreERt2 (Osr1GCE) "knock-in" allele both abolishes Osr1 gene function and…

Investigators

  • Andrew P. McMahon

Research Tool

Pdx1-CreER Transgenic Mice

Pancreatic cells are derived from Pdx1 (pancreatic and duodenal homeobox 1)-expressing progenitors throughout embryogenesis. This conditional transgenic strain expresses Cre/Esr1 from the mouse Pdx1 promoter. Cytoplasmic stores of Cre recombinase…

Investigators

  • Douglas Melton

Research Tool

B6N.Sox2-Cre Transgenic Mice

These transgenic mice express Cre recombinase under the control of the mouse SRY-box containing gene 2 promoter. The transgene integrated into an intron of Edil3 (EGF-like repeats and discoidin I-like domains 3). The insertion results in a…

Investigators

  • Andrew P. McMahon

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