DBD Search
Vivian Berlin
Executive Director, HMS
Displaying: 21 - 30 of 75 Results
Invention
Induced motor neurons (iMNs)
The team converted mouse and human fibroblasts into iMNs by the forced expression of select transcription factors. Producing motor neurons this way is much less labor intensive than having to go through the process of creating induced pluripotent…
Investigators
- Kevin Carl Eggan
- Justin K. Ichida
- Esther Yesde Son
- Brian J. Wainger
- Clifford Woolf
Invention
Animal model of diabetes and obesity
Mice with the JNK 1 and JNK2 genes knocked out were crossed with the obese mouse line (ob/ob) to create a mouse model of diabetes and obesity. These mice exhibit many of the hallmark metabolic pertubations characteristic in diabetes and obesity.
Investigators
- Gokhan S. Hotamisligil
- Michael Karin
Research Tool
Shh Targeted Mutation Mice
Mice that are homozygous for the Shhtm2Amc targeted mutation are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. This conditional mutant contains two loxP sites flanking exon 2 of the targeted…
Investigators
- Andrew P. McMahon
Research Tool
Hoxb7-cre Transgenic Mice
Mice hemizygous for the transgenic insert are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. Homozygotes are not viable. These transgenic mice express the Cre recombinase under the control of the…
Investigators
- Andrew P. McMahon
Research Tool
Wnt3a Knock Out Mice
Mice that are heterozygous for the targeted mutation are viable, fertile, normal in size and, with the exception of a kinked tail, do not display any gross physical or behavioral abnormalities. Homozygous null mice have an embryonic lethal…
Investigators
- Andrew P. McMahon
Research Tool
ROSA 26Sortm1(Smo/EYFP) Transgenic Mice
When these mice are used in conjunction with a Cre recombinase-expressing strain, successful Cre-mediated excision results in the constitutive expression of the Smo/EYFP fusion gene (monitored by using EYFP-specific fluorescence protocols) and…
Investigators
- Andrew P. McMahon
Research Tool
Col1a1-tetO-H2B-mcherry Targeted Mutation Mice
These Col1a1-tetO-H2B-mcherry mutant mice contain a tet-responsive element (tetO) and a histone H2B-mCherry fusion protein, targeted to the collagen, type I, alpha 1 (Col1a1) locus. Homozygous are viable, fertile, and normal is size. Animals have a…
Investigators
- Kevin Carl Eggan
Research Tool
Tmem100-GCE Transgemic Mice
These transgenic mice express the eGFPCreERT2 (Enhanced Green Fluorescent Protein and cre/ESR1) fusion gene under the direction of the mouse Tmem100, transmembrane protein 100, promoter. Transgene expression is detected in developing nephrons of the…
Investigators
- Andrew P. McMahon
Research Tool
Meox1-nucTagRFP-T-IRES-CE Transgenic Mice
These Meox1-nucTagRFP-T-IRES-CE mutant mice have a tamoxifen inducible Cre-mediated recombination system and express the nuclear-localized Tag-RFPT variant of Red Fluorescent Protein under the direction of the mouse Meox1, mesenchyme homeobox 1,…
Investigators
- Andrew P. McMahon
Research Tool
B6(D2)-Tg(CAG-Brainbow1.0)2 Transgenic Mice
These transgenic mice carry the Brainbow 1.0 cassette, incorporating dTomato, mCerulean, and EYFP, driven by the broadly-expressed CAG (CMV-chicken beta actin) promoter. These fluorescent markers are useful in tracing cell lineage. This strain, line…
Investigators
- Kevin Carl Eggan