DBD Search
Vivian Berlin
Executive Director, HMS
Displaying: 21 - 30 of 75 Results
Invention
Potent OGT inhibitors for the treatment of cancer and diabetic complications
First-in-class and potent OGT inhibitors The Walker group has developed novel high throughput assays (HTS) and screened 200,000 compounds at the Institute for Chemistry and Cell Biology (ICCB) at Harvard Medical School, and identified several…
Investigators
- Suzanne Walker Kahne
- Michael B Lazarus
- Benjamin J. Gross
Invention
Lead compounds for the treatment of pain
The invention is a novel synthetic pathway to the generation of nonpeptidic ligands for the mu opioid class of G-protein coupled receptors. The system uses stereochemical variation and acyclic geometric stereocontrol to generate diversity among its…
Investigators
- Gregory L. Verdine
- Bryce A. Harrison
- Tiffany Kaye Malinky Gierasch
- Zhangjie Shi
Research Tool
S100b-GCE
These transgenic mice express the eGFPCreERT2 (Enhanced Green Fluorescent Protein and cre/ESR1) fusion gene under the direction of the mouse S100b, S100 protein, beta polypeptide, neural, promoter. Transgene expression is detected in chondrocytes in…
Investigators
- Andrew P. McMahon
Research Tool
FoxD1GCE eGFPCreERT2 Transgenic Mice
Heterozygous mice are viable and fertile, normal in size and do not display any gross physical or behavioral abnormalities. The DI states that the strain is homozygous lethal. The Foxd1GCE allele expresses an eGFPCreERT2 fusion protein (EGFP and…
Investigators
- Andrew P. McMahon
Research Tool
Wnt11 knock-out
Mice heterozygous for this targeted mutation are viable and fertile with normal kidney size and histology. Homozygotes exhibit some embryonic lethality and will die by 2 days post partem. While the cause of death is unclear, these neonates have…
Investigators
- Andrew P. McMahon
Research Tool
Osx1-GFP::Cre Transgenic Mice
Mice hemizygous for this Osx1-GFP::Cre transgene are viable and fertile. The transgene carries both tTA under the regulation of the osterix (Sp7) promoter and, just downstream, a tetracycline responsive element (TRE; tetO)-controlled GFP/Cre fusion…
Investigators
- Andrew P. McMahon
Research Tool
Cited1-nuc-TagRFP-T Transgenic Mice
These transgenic mice express the Tag-RFPT variant of Red Fluorescent Protein under the direction of the mouse Cited1, Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1, promoter. TagRFP is the optimized monomeric…
Investigators
- Andrew P. McMahon
Research Tool
Sox2Cre Transgenic Mice
These transgenic mice express Cre recombinase under the control of the mouse SRY-box containing gene 2 promoter. The transgene integrated into an intron of Edil3 (EGF-like repeats and discoidin I-like domains 3). The insertion results in a…
Investigators
- Andrew P. McMahon
Research Tool
L7Cre Transgenic Mice
Hemizygous mice are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities. Cre activity is observed in parasagittal domains of the cerebellum beginning at embryonic day 17 (E17). At E19, low level…
Investigators
- Andrew P. McMahon
Research Tool
Wnt7bc3 LoxP Targeted Mutation Mice
Mice homozygous for the Wnt7bc3 allele are viable and fertile, with loxP sites flanking exon 3 of the targeted gene. When bred to mice that express Cre recombinase, the resulting offspring will have this region deleted in the cre-expressing…
Investigators
- Douglas Melton