Vivian Berlin

Executive Director, HMS

Displaying: 21 - 30 of 75 Results

Invention

Modulating gene activity on chondrocytes

Transgenic mice were generated in which the regulatory sequences for the Col2a1 gene were used to drive expression of Cre recombinase in chondrocytes. The strain initiates Cre-mediated recombination predominantly in immature chondrocytes and the…

Investigators

  • Andrew P. McMahon
  • Fanxin Long

Invention

Induced motor neurons (iMNs)

The team converted mouse and human fibroblasts into iMNs by the forced expression of select transcription factors. Producing motor neurons this way is much less labor intensive than having to go through the process of creating induced pluripotent…

Investigators

  • Kevin Carl Eggan
  • Justin K. Ichida
  • Esther Yesde Son
  • Brian J. Wainger
  • Clifford Woolf

Research Tool

gene trap ROSA 26 Targeted Mutation Mice

These mice contain a sequence encoding an intracellular portion of the mouse Notch1 gene (amino acids 1749-2293), but lacking the c-terminal PEST domain, and Green Fluorescent Protein, GFP, inserted into the GT(ROSA)26Sor locus. Expression of the…

Investigators

  • Douglas Melton

Research Tool

Wnt11-myrTagRFP-IRES-CE Transgenic Mice

These Wnt11-myrTagRFP-IRES-CE mutant mice have a tamoxifen inducible Cre-mediated recombination system and express the Tag-RFPT variant of Red Fluorescent Protein under the direction of the mouse Wnt11, wingless-related MMTV integration site 11,…

Investigators

  • Andrew P. McMahon

Research Tool

Pax4-cre Transgenic Mice

Pax4-cre transgenic mice have the mouse paired box gene 4 (Pax4) promoter directing expression of an enhanced green fluorescent protein fused to a Tet-off cassette (EGFP/tTA). The transgene also contains a tetracycline-responsive element with a CMV…

Investigators

  • Douglas Melton

Research Tool

Cldn6CIHV Targeted Mutation Mice

In this strain, the Cldn6CIHV allele replaces the entire coding region of the claudin 6 (Cldn6) locus with a CreERT2 fusion protein, an internal ribosome entry site (IRES), and a histone H2B-Venus fluorescent protein. This abolishes gene expression.…

Investigators

  • Douglas Melton

Research Tool

Sox2-cre Transgenic Mice

The Sox2Cre transgene was designed with 12.5 kb of upstream regulatory sequence from the mouse Sox2 locus (SRY-box containing gene 2), a chicken _-actin intron, a Cre recombinase gene, and a rabbit _-globin poly(A) sequence. This transgene was…

Investigators

  • Andrew P. McMahon

Research Tool

Lfng-nuc-Tag-RFP-T-IRES-CE Transgenic Mice

These Lfng-nuc-Tag-RFP-T-IRES-CE mutant mice have a tamoxifen inducible Cre-mediated recombination system and express the Tag-RFPT variant of Red Fluorescent Protein under the direction of the mouse Lfng, LFNG O-fucosylpeptide…

Investigators

  • Andrew P. McMahon

Research Tool

Wnt9bc LoxP Targeted Mutation Mice

Mice homozygous for the Wnt9bc allele are viable and fertile, with loxP sites flanking exon 2 of the targeted gene. When bred to mice that express Cre recombinase, the resulting offspring will have this region deleted in the cre-expressing…

Investigators

  • Andrew P. McMahon

Research Tool

Shh Targeted Mutation Mice

Mice that are homozygous for the Shhtm2Amc targeted mutation are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. This conditional mutant contains two loxP sites flanking exon 2 of the targeted…

Investigators

  • Andrew P. McMahon

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