DBD Search
Vivian Berlin
Executive Director, HMS
Displaying: 21 - 30 of 75 Results
Invention
Induced motor neurons (iMNs)
The team converted mouse and human fibroblasts into iMNs by the forced expression of select transcription factors. Producing motor neurons this way is much less labor intensive than having to go through the process of creating induced pluripotent…
Investigators
- Kevin Carl Eggan
- Justin K. Ichida
- Esther Yesde Son
- Brian J. Wainger
- Clifford Woolf
Invention
Animal model of diabetes and obesity
Mice with the JNK 1 and JNK2 genes knocked out were crossed with the obese mouse line (ob/ob) to create a mouse model of diabetes and obesity. These mice exhibit many of the hallmark metabolic pertubations characteristic in diabetes and obesity.
Investigators
- Gokhan S. Hotamisligil
- Michael Karin
Research Tool
Cldn6CIHV Targeted Mutation Mice
In this strain, the Cldn6CIHV allele replaces the entire coding region of the claudin 6 (Cldn6) locus with a CreERT2 fusion protein, an internal ribosome entry site (IRES), and a histone H2B-Venus fluorescent protein. This abolishes gene expression.…
Investigators
- Douglas Melton
Research Tool
Sox2-cre Transgenic Mice
The Sox2Cre transgene was designed with 12.5 kb of upstream regulatory sequence from the mouse Sox2 locus (SRY-box containing gene 2), a chicken _-actin intron, a Cre recombinase gene, and a rabbit _-globin poly(A) sequence. This transgene was…
Investigators
- Andrew P. McMahon
Research Tool
Lfng-nuc-Tag-RFP-T-IRES-CE Transgenic Mice
These Lfng-nuc-Tag-RFP-T-IRES-CE mutant mice have a tamoxifen inducible Cre-mediated recombination system and express the Tag-RFPT variant of Red Fluorescent Protein under the direction of the mouse Lfng, LFNG O-fucosylpeptide…
Investigators
- Andrew P. McMahon
Research Tool
Wnt9bc LoxP Targeted Mutation Mice
Mice homozygous for the Wnt9bc allele are viable and fertile, with loxP sites flanking exon 2 of the targeted gene. When bred to mice that express Cre recombinase, the resulting offspring will have this region deleted in the cre-expressing…
Investigators
- Andrew P. McMahon
Research Tool
Shh Targeted Mutation Mice
Mice that are homozygous for the Shhtm2Amc targeted mutation are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. This conditional mutant contains two loxP sites flanking exon 2 of the targeted…
Investigators
- Andrew P. McMahon
Research Tool
Hoxb7-cre Transgenic Mice
Mice hemizygous for the transgenic insert are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. Homozygotes are not viable. These transgenic mice express the Cre recombinase under the control of the…
Investigators
- Andrew P. McMahon
Research Tool
Wnt3a Knock Out Mice
Mice that are heterozygous for the targeted mutation are viable, fertile, normal in size and, with the exception of a kinked tail, do not display any gross physical or behavioral abnormalities. Homozygous null mice have an embryonic lethal…
Investigators
- Andrew P. McMahon
Research Tool
ROSA 26Sortm1(Smo/EYFP) Transgenic Mice
When these mice are used in conjunction with a Cre recombinase-expressing strain, successful Cre-mediated excision results in the constitutive expression of the Smo/EYFP fusion gene (monitored by using EYFP-specific fluorescence protocols) and…
Investigators
- Andrew P. McMahon