DBD Search
Vivian Berlin
Executive Director, HMS
Displaying: 21 - 30 of 75 Results
Invention
Induced motor neurons (iMNs)
The team converted mouse and human fibroblasts into iMNs by the forced expression of select transcription factors. Producing motor neurons this way is much less labor intensive than having to go through the process of creating induced pluripotent…
Investigators
- Kevin Carl Eggan
- Justin K. Ichida
- Esther Yesde Son
- Brian J. Wainger
- Clifford Woolf
Invention
Animal model of diabetes and obesity
Mice with the JNK 1 and JNK2 genes knocked out were crossed with the obese mouse line (ob/ob) to create a mouse model of diabetes and obesity. These mice exhibit many of the hallmark metabolic pertubations characteristic in diabetes and obesity.
Investigators
- Gokhan S. Hotamisligil
- Michael Karin
Research Tool
ROSA 26Sortm1(Smo/EYFP) Transgenic Mice
When these mice are used in conjunction with a Cre recombinase-expressing strain, successful Cre-mediated excision results in the constitutive expression of the Smo/EYFP fusion gene (monitored by using EYFP-specific fluorescence protocols) and…
Investigators
- Andrew P. McMahon
Research Tool
Col1a1-tetO-H2B-mcherry Targeted Mutation Mice
These Col1a1-tetO-H2B-mcherry mutant mice contain a tet-responsive element (tetO) and a histone H2B-mCherry fusion protein, targeted to the collagen, type I, alpha 1 (Col1a1) locus. Homozygous are viable, fertile, and normal is size. Animals have a…
Investigators
- Kevin Carl Eggan
Research Tool
Tmem100-GCE Transgemic Mice
These transgenic mice express the eGFPCreERT2 (Enhanced Green Fluorescent Protein and cre/ESR1) fusion gene under the direction of the mouse Tmem100, transmembrane protein 100, promoter. Transgene expression is detected in developing nephrons of the…
Investigators
- Andrew P. McMahon
Research Tool
Meox1-nucTagRFP-T-IRES-CE Transgenic Mice
These Meox1-nucTagRFP-T-IRES-CE mutant mice have a tamoxifen inducible Cre-mediated recombination system and express the nuclear-localized Tag-RFPT variant of Red Fluorescent Protein under the direction of the mouse Meox1, mesenchyme homeobox 1,…
Investigators
- Andrew P. McMahon
Research Tool
B6(D2)-Tg(CAG-Brainbow1.0)2 Transgenic Mice
These transgenic mice carry the Brainbow 1.0 cassette, incorporating dTomato, mCerulean, and EYFP, driven by the broadly-expressed CAG (CMV-chicken beta actin) promoter. These fluorescent markers are useful in tracing cell lineage. This strain, line…
Investigators
- Kevin Carl Eggan
Research Tool
Shh::gfp Targeted Mutation Mice
While mice heterozygous for the Shh::gfp allele are viable, fertile, and indistinguishable from wild-type littermates, homozygotes are stillborn and show developmental defects consistent with reduced Sonic Hedgehog (Shh) signaling. The Shh::gfp…
Investigators
- Andrew P. McMahon
Research Tool
Ihh Knock Out Mice
Mice that are heterozygous for the targeted allele are viable and fertile. Mice homozygous for this mutation have a lethal phenotype. Half of homozygous null mice have an embryonic lethal phenotype, dying between 10.5 to 12.5 days post coitum. The…
Investigators
- Andrew P. McMahon
Research Tool
Wnt4 Knock Out Mice
Mice that are heterozygous for the targeted mutation are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. Homozygous null mice have a perinatal lethal phenotype and die within 24 hours of birth.…
Investigators
- Andrew P. McMahon