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Fzd2 - novel anti-cancer therapeutic target
The role of β-catenin accumulation in the development of tumorigenicity has been well documented to date, with various mutations in β-catenin, APC, and axin genes typically to blame. Although β-catenin accumulation plays a role in hepatocellular…
Investigators
- Gavin MacBeath
- Taran S. Gujral
New therapeutic pathway for autoimmune and inflammatory disorders
A recently-discovered class of T cells - T follicular regulatory (TFR) cells - controls the production of antibodies. TFR cells inhibit T follicular helper (TFH) cells, which mediate antibody production in lymph nodes. Several autoimmune diseases…
Investigators
- Arlene H. Sharpe
- Peter Sage
- Loise Francisco
SPECT diagnostic agents for Parkinson’s Disease and ADHD
The Harvard research team has over two decades of experience in the design and synthesis of molecules that target monoamine uptake potently and selectively. The class of compounds utilized for the design of the subject SPECT agents is the…
Investigators
- Bertha Madras
- Paul Blundell
- Alan J. Fischman
- Peter Meltzer
- Alun G. Jones
- Ashfaq Mahmood
Novel methods for generating regulatory T-cells
Regulatory T-cells (Tregs) are key mediators of peripheral tolerance that can actively suppress effector T-cells, inhibit inflammation and mediate self-tolerance. Unlike naturally occurring Tregs (nTregs) which develop in the thymus,…
Investigators
- Arlene H. Sharpe
- Loise Francisco
- Vijay K. Kuchroo
Directed evolution of proteins and nucleic acids using nonhomologous random recombination
The nonhomologous random recombination (NRR) method allows portions of nucleic acids to be recombined at sites where there is little or no sequence homology. This increases the frequency at which novel sequences are generated, allowing a more…
Investigators
- David R. Liu
- Joshua Bittker
Drug-inducible RNA aptaswitch for regulating eukaryotic protein expression
Using in vivo evolution techniques, scientists in the Liu laboratory have engineered a drug-inducible aptaswitch for regulating eukaryotic protein expression at the transcription level. This aptaswitch consists of two modular RNA elements: a…
Investigators
- David R. Liu
- Allen R. Buskirk
- Polina Kehayova
A system for the continuous directed evolution of biomolecules
Researchers in the laboratory of Professor David Liu have developed a platform that enables the continuous directed evolution of gene-encoded molecules that can be linked to protein production in E. coli. During phage-assisted continuous evolution…
Investigators
- David R. Liu
- Kevin M. Esvelt
- Jacob Carlson
- Ahmed Hussein Badran
Small-molecule-triggered intein splicing as a universal switch for protein activation
Researchers in the laboratory of Professor David Liu have used directed evolution techniques to evolve an intein-based molecular switch that transduces binding of a small molecule into the activation of an arbitrary protein of interest. To create…
Investigators
- David R. Liu
- Allen R. Buskirk
- Sun H. Peck