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Therapeutic strategies for autism spectrum disorder sensory (tactile) hypersensitivity, anxiety and social interaction deficits
This is a novel strategy to treat tactile hypersensitivity, anxiety, and social interaction deficits by targeting the peripheral nervous system without drugging the brain.Autism spectrum disorders (ASDs), including Rett Syndrome, as well as Fragile…
Investigators
- David Ginty
- Lauren Orefice
A novel and effective technology for target-based screening
Target-based screening allows for rapid identification of ligands for an increasing number of macromolecular targets and is commonly used in drug discovery.The present invention uses interaction-dependent PCR (IDPCR) to selectively identify…
Investigators
- David R. Liu
- Christoph E. Dumelin
- David J. Gorin
- Lynn McGregor
Targeting spiral ganglion neurons for treatment of hearing loss
Hearing loss makes interactions with the world challenging for over 30 million people in the United States. While cochlear implants and hearing aid devices can ameliorate hearing loss, they often fail to restore the function of spiral ganglion…
Investigators
- Lisa Goodrich
Genomic Analysis Tool Box
Cancer genomes frequently harbor high mutation rates, complex structural variations, and are characterized by genome instability. Detailed understanding of these characteristics of the cancer genome is necessary for pinpointing the cause of tumor…
Investigators
- Peter Park
A system for in vivo generation of protective CD8+ T lymphocytes and other cells of hematopoietic origin
Differentiated CD8+ effector T cells mediate long-term immunity and protection against infectious diseases and cancer. Naive T cells are refractory to transduction with viral vectors without extensive ex vivo manipulations. A team of researchers at…
Investigators
- Arlene H. Sharpe
- Nicholas Haining
Immunology and Computational Biology Partnership
Professors Diane Mathis and Christophe Benoist at Harvard Medical School, together with other world-renowned immunologists and computational biologists from multiple research institutions, have created the Immunological Genome Project – Immgen…
Investigators
- Diane J. Mathis
- Christophe O. Benoist
Novel methods for generating regulatory T-cells
Regulatory T-cells (Tregs) are key mediators of peripheral tolerance that can actively suppress effector T-cells, inhibit inflammation and mediate self-tolerance. Unlike naturally occurring Tregs (nTregs) which develop in the thymus,…
Investigators
- Arlene H. Sharpe
- Loise Francisco
- Vijay K. Kuchroo
A system for the continuous directed evolution of biomolecules
Researchers in the laboratory of Professor David Liu have developed a platform that enables the continuous directed evolution of gene-encoded molecules that can be linked to protein production in E. coli. During phage-assisted continuous evolution…
Investigators
- David R. Liu
- Kevin M. Esvelt
- Jacob Carlson
- Ahmed Hussein Badran
Interaction-dependent PCR: Multiplexed identification of ligand-target pairs from DNA-encoded ligand/target libraries in a single solution-phase experiment
IDPCR is based on the melting temperature difference between duplex DNA formed intramolecularly versus intermolecularly. Binding of a target to its ligand would increase the effective molarity of single-stranded DNA oligonucleotides linked to the…
Investigators
- David R. Liu
- David J. Gorin
- Adam S. Kamlet
- Lynn McGregor
- Christoph E. Dumelin
Novel target in NK cell mediated antigen specific memory responses
The von Andrian laboratory discovered a novel mechanism for inducing antigen specific immunological memory. Their research examines the role of a molecular target not previously known to be associated with the natural killer (NK) cell mediated…
Investigators
- Ulrich H. von Andrian
- Silke Paust