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Highly conformal tungsten nitride films for use in microelectronics and semiconductors

The invention describes a method of producing a uniform, smooth and conformal coating of tungsten nitride, synthesized by atomic layer deposition (ALD). The silver-colored coating (or film) is metallic and a good electrical conductor.

DBD

  • Christopher Petty

Investigators

  • Roy Gordon
  • Jill Becker
  • Seigi Suh

Electrically-driven nanoscale lasers

This invention is the first demonstration of an electrically driven nanoscale laser. A CdS nanowire, comprising a Fabry-Perot cavity, in contact with an electrode distributed along its length or crossing a Si nanowire, lases above a threshold…

DBD

  • Christopher Petty

Investigators

  • Charles Lieber
  • Xiangfeng Duan
  • Yu Huang
  • Ritesh Agarwal

Lead compounds for the treatment of pain

The invention is a novel synthetic pathway to the generation of nonpeptidic ligands for the mu opioid class of G-protein coupled receptors. The system uses stereochemical variation and acyclic geometric stereocontrol to generate diversity among its…

DBD

  • Vivian Berlin

Investigators

  • Gregory Verdine
  • Bryce Harrison
  • Tiffany Gierasch
  • Zhangjie Shi

Modulating gene activity on chondrocytes

Transgenic mice were generated in which the regulatory sequences for the Col2a1 gene were used to drive expression of Cre recombinase in chondrocytes. The strain initiates Cre-mediated recombination predominantly in immature chondrocytes and the…

DBD

  • Vivian Berlin

Investigators

  • Andrew McMahon
  • Fanxin Long

Drug-inducible RNA aptaswitch for regulating eukaryotic protein expression

Using in vivo evolution techniques, scientists in the Liu laboratory have engineered a drug-inducible aptaswitch for regulating eukaryotic protein expression at the transcription level. This aptaswitch consists of two modular RNA elements: a…

DBD

  • Irit Ben-Chelouche

Investigators

  • David Liu
  • Allen Buskirk
  • Polina Kehayova

Animal model of diabetes and obesity

Mice with the JNK 1 and JNK2 genes knocked out were crossed with the obese mouse line (ob/ob) to create a mouse model of diabetes and obesity. These mice exhibit many of the hallmark metabolic pertubations characteristic in diabetes and obesity.

DBD

  • Vivian Berlin

Investigators

  • Gokhan Hotamisligil
  • Michael Karin

Monoclonal IgE anti-ovalbumin antibody

A laboratory from the Harvard School of Public Health has developed a monoclonal Ig E mouse anti-ovalbumin. This antibody is useful as a positive control in ELISA assays used to measure the level of IgE anti-ovalbumin antibodies in mouse models of…

DBD

  • Grant Zimmermann

Investigators

  • Lester Kobzik
  • Aiyappa Palecanda

Bead-based polymerase colony microarrays and nucleic acid sequencing ("Polony-FISSEQ Beads")

Foundational work of Dr. George Church has enabled the production and use of replicable arrays of polymerase-amplified nucleic acid colonies (so-called "polonies") on semisolid support matrices (see Harvard Case #1438). The present invention extends…

DBD

  • Maryanne Fenerjian

Investigators

  • George Church
  • Jay Shendure
  • Gregory Porreca
  • Jun Zhu

Modular conditional knockout:  Precise temporal control of protein degradation in living cells

Polyubiquitinated proteins in eukaryotes are directed to the proteasome for degradation. It is generally accepted that proteasome-mediated proteolysis depends strictly upon ubiquitination, as disruption of that process has been observed to halt…

DBD

  • Maryanne Fenerjian

Investigators

  • George Church
  • Daniel Janse

Enhanced fidelity of sub-nanogram amplification

The importance of nucleic acid amplification from trace amounts of biological sample has increased with the expansion of genomic sequencing in various clinical and research-oriented applications. This invention characterizes techniques to reduce…

DBD

  • Maryanne Fenerjian

Investigators

  • George Church
  • Kun Zhang

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