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Displaying: 141 - 150 of 270 Results
Small-molecule-triggered intein splicing as a universal switch for protein activation
Researchers in the laboratory of Professor David Liu have used directed evolution techniques to evolve an intein-based molecular switch that transduces binding of a small molecule into the activation of an arbitrary protein of interest. To create…
DBD
- Irit Ben-Chelouche
Investigators
- David Liu
- Allen Buskirk
- Sun Peck
Asynchronous circuit techniques for memory error correction
This invention describes a circuit technique for rapidly and efficiently correcting for read and write data errors in a digital semiconductor memory. More specifically, it involves the design of an error-correcting circuit (ECC) as applied to high…
DBD
- Sam Liss
Investigators
- Woodward Yang
- Elaine Ou
A self-sustained soliton oscillator utilizing nonlinear transmission lines and spectrum-preservice nonlinear amplification
The invention describes new methods and apparatus for implementing stable self-starting and self-sustaining electrical nonlinear pulse (e.g., soliton, cnoidal wave, or quasi-soliton) oscillators. In one embodiment, a nonlinear pulse oscillator is…
DBD
- Sam Liss
Investigators
- Donhee Ham
- David Ricketts
- Xiaofeng Li
- Matthew DePetro
DBD
- Christopher Petty
Investigators
- Charles Lieber
- Wei Lu
- Jie Xiang
- Brian Timko
- Yue Wu
- Hao Yan
A transgenic reporter system can be used for recombination-mediated modulation of gene activity in the developing mouse embryo
A transgenic reporter system consisting of a tamoxifen-inducible form of Cre recombinase (Cre-ERTM) that can be used for recombination-mediated modulation of gene activity in the developing mouse embryo. Using the enhancer of the Wnt1 gene to…
DBD
- Vivian Berlin
Investigators
- Andrew McMahon
- Paul Danielian
- David Rowitch
Transgenic mice with fluorescently tagged neuronal mitochondria as a new tool to study axonal transport
Homozygous transgenic mouse stain B6.Cg-Tg(Thy1-CFP/COX8A)S2Lich/J (also know as Thy-CFP-MitoS) was developed by Dr. Jeffrey W. Lichtman at Harvard University. The mice express mitochondria-targeting Cyan Fluorescent Protein (CFP) in neuronal cell…
DBD
- Yelena Bisharyan
Investigators
- Jeffrey Lichtman
- Florence Bareyre
- Thomas Misgeld
- Martin Kerschensteiner
HEK293T cells stably express Divalent Metal Transporter-1 for use in a model system to screen for inhibitors of iron uptake
This invention is a cell-based screen that enables the rapid identification of iron transport inhibitors. From initial efforts, 10 small molecule inhibitors of transport have been identified, and ongoing studies focus on characterizing their…
DBD
- Grant Zimmermann
Investigators
- Marianne Wessling-Resnick
- Peter Buckett
"MoleProbe": A real-time molecular diagnostic device
The invention is a novel engineering method for generation of freestanding 2-D and 3-D tissue structures. Biopolymers (proteins, carbohydrates, lipids, nucleic acids or combinations thereof) are deposited onto a transitional polymer surface with a…
Investigators
- Kevin Parker
Bubble expansion of homogeneous epoxy suspensions of nanowires and carbon nanotubes to produce large area films
The invention describes a general and scalable, low temperature method involving bubble expansion of homogeneous epoxy suspensions of nanowires and carbon nanotubes to produce large area films. The nanowires and carbon nanotubes are well aligned in…
DBD
- Christopher Petty
Investigators
- Charles Lieber
- Guihua Yu
- Anyuan Cao
Patterning of metals and metal compounds using ionotropic polymers
Patterning surfaces to create some function is a core technology propelling our technical society. The most important such technology, photolithography, is used to create IC chips with nanoscale features. It is also the most expensive with fab…
DBD
- Sam Liss
Investigators
- George Whitesides
- Michal Lahav
- Max Narovlyansky
- Adam Winkleman
- Raquel Perez-Castillejos
- Emily Weiss
- Leonard Rodriguez