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Displaying: 171 - 180 of 270 Results
A system for the continuous directed evolution of biomolecules
Researchers in the laboratory of Professor David Liu have developed a platform that enables the continuous directed evolution of gene-encoded molecules that can be linked to protein production in E. coli. During phage-assisted continuous evolution…
DBD
- Irit Ben-Chelouche
Investigators
- David Liu
- Kevin Esvelt
- Jacob Carlson
- Ahmed Badran
A to D converter data calibration in real-time delivers faster conversion rates
The new digital data calibration technique allows any pipeline ADC to operate at a speed about 2 bits faster than currently available ADCs. For example, an 8-bit ADC could potentially run at 12 bits, compared to only the 10 bits maximum that might…
DBD
- Sam Liss
Investigators
- Donhee Ham
- Nan Sun
Voltage emergency prediction: Signature-based approach to reducing voltage emergencies
To reduce the gap between nominal and worst-case operating voltages, Harvard researchers have developed a “voltage emergency predictor” that identifies when emergencies are imminent and prevents their occurrence. A voltage emergency predictor…
DBD
- Sam Liss
Investigators
- Gu-Yeon Wei
- David Brooks
- Michael Smith
- Glenn Holloway
- Meeta Gupta
- Vijay Reddi
Metabolic labeling and direct imaging of choline-containing phospholipids in vivo
A functional analog of a metabolic phospholipid precursor has been devised that, when contacted with cells, becomes incorporated into a cells endogenous phospholipids through cellular metabolic processes. The resulting phospholipids contain a moiety…
DBD
- Grant Zimmermann
Investigators
- Adrian Salic
Potent OGT inhibitors for the treatment of cancer and diabetic complications
First-in-class and potent OGT inhibitors The Walker group has developed novel high throughput assays (HTS) and screened 200,000 compounds at the Institute for Chemistry and Cell Biology (ICCB) at Harvard Medical School, and identified several…
DBD
- Vivian Berlin
Investigators
- Suzanne Walker Kahne
- Michael Lazarus
- Benjamin Gross
Gluconeogenesis as a pro-survival treatment for neurons under stress
A series of AAV-based gene therapy approaches to reprogram certain metabolic enzymes in rod and cone cells in the eye to promote survival in degenerative conditions such as retinitis pigmentosa. Additionally, an independent series of such vectors…
DBD
- Grant Zimmermann
Investigators
- Constance Cepko
- Claudio Punzo
The SMALL Microscope: Scanning microscopy on a chip
Fresnel zone plates use extremely short focal lengths. The Crozier lab has demonstrated that an imaging system with a short focal length zone plate, in combination with a spatial filter formed by a relay lens, can provide a high collection…
DBD
- Sam Liss
Investigators
- Kenneth Crozier
- Ethan Schonbrun
Knockout mouse model for human liver cancer
While most hepatocytes in healthy liver are resting cells, deletion of Mad2 in liver activates the cell cycles and causes proliferation of hepatocytes. Cre-mediated, simultaneous liver-specific knockout of Mad2 and p53 induces mouse cancer which…
DBD
- Grant Zimmermann
Investigators
- Peter Sorger
- Ying Yue
Oligopaints as a means for marking chromosomes with superior resolution and labeling functionality
Oligopaints could provide a means for marking chromosomes with superior resolution and labeling functionality than currently commercially available chromosome paint alternatives. In addition, the technology may be applied to any organism for which…
DBD
- Maryanne Fenerjian
Investigators
- Chao-ting Wu
- George Church
- Benjamin Williams
Interaction-dependent PCR: Multiplexed identification of ligand-target pairs from DNA-encoded ligand/target libraries in a single solution-phase experiment
IDPCR is based on the melting temperature difference between duplex DNA formed intramolecularly versus intermolecularly. Binding of a target to its ligand would increase the effective molarity of single-stranded DNA oligonucleotides linked to the…
DBD
- Irit Ben-Chelouche
Investigators
- David Liu
- David Gorin
- Adam Kamlet
- Lynn McGregor
- Christoph Dumelin