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Displaying: 171 - 180 of 266 Results
A to D converter data calibration in real-time delivers faster conversion rates
The new digital data calibration technique allows any pipeline ADC to operate at a speed about 2 bits faster than currently available ADCs. For example, an 8-bit ADC could potentially run at 12 bits, compared to only the 10 bits maximum that might…
DBD
- Sam Liss
Investigators
- Donhee Ham
- Nan Sun
Metabolic labeling and direct imaging of choline-containing phospholipids in vivo
A functional analog of a metabolic phospholipid precursor has been devised that, when contacted with cells, becomes incorporated into a cells endogenous phospholipids through cellular metabolic processes. The resulting phospholipids contain a moiety…
DBD
- Grant Zimmermann
Investigators
- Adrian Salic
Potent OGT inhibitors for the treatment of cancer and diabetic complications
First-in-class and potent OGT inhibitors The Walker group has developed novel high throughput assays (HTS) and screened 200,000 compounds at the Institute for Chemistry and Cell Biology (ICCB) at Harvard Medical School, and identified several…
DBD
- Vivian Berlin
Investigators
- Suzanne Walker Kahne
- Michael Lazarus
- Benjamin Gross
Gluconeogenesis as a pro-survival treatment for neurons under stress
A series of AAV-based gene therapy approaches to reprogram certain metabolic enzymes in rod and cone cells in the eye to promote survival in degenerative conditions such as retinitis pigmentosa. Additionally, an independent series of such vectors…
DBD
- Grant Zimmermann
Investigators
- Constance Cepko
- Claudio Punzo
The SMALL Microscope: Scanning microscopy on a chip
Fresnel zone plates use extremely short focal lengths. The Crozier lab has demonstrated that an imaging system with a short focal length zone plate, in combination with a spatial filter formed by a relay lens, can provide a high collection…
DBD
- Sam Liss
Investigators
- Kenneth Crozier
- Ethan Schonbrun
Knockout mouse model for human liver cancer
While most hepatocytes in healthy liver are resting cells, deletion of Mad2 in liver activates the cell cycles and causes proliferation of hepatocytes. Cre-mediated, simultaneous liver-specific knockout of Mad2 and p53 induces mouse cancer which…
DBD
- Grant Zimmermann
Investigators
- Peter Sorger
- Ying Yue
Oligopaints as a means for marking chromosomes with superior resolution and labeling functionality
Oligopaints could provide a means for marking chromosomes with superior resolution and labeling functionality than currently commercially available chromosome paint alternatives. In addition, the technology may be applied to any organism for which…
DBD
- Maryanne Fenerjian
Investigators
- Chao-ting Wu
- George Church
- Benjamin Williams
Interaction-dependent PCR: Multiplexed identification of ligand-target pairs from DNA-encoded ligand/target libraries in a single solution-phase experiment
IDPCR is based on the melting temperature difference between duplex DNA formed intramolecularly versus intermolecularly. Binding of a target to its ligand would increase the effective molarity of single-stranded DNA oligonucleotides linked to the…
DBD
- Irit Ben-Chelouche
Investigators
- David Liu
- David Gorin
- Adam Kamlet
- Lynn McGregor
- Christoph Dumelin
Improved amide synthesis using silver as a catalyst
The Madix and Friend laboratories have developed a novel amide synthesis that uses metallic silver or silver-based alloy with oxygen adsorbed on the surface to catalyze the reaction of primary or secondary amines with alcohols or aldehydes. The…
DBD
- Christopher Petty
Investigators
- Cynthia Friend
- Robert Madix
- Ling Zhou
- Bingjun Xu
- Cassandra Freyschlag
Novel target in NK cell mediated antigen specific memory responses
The von Andrian laboratory discovered a novel mechanism for inducing antigen specific immunological memory. Their research examines the role of a molecular target not previously known to be associated with the natural killer (NK) cell mediated…
DBD
- Irit Ben-Chelouche
Investigators
- Ulrich von Andrian
- Silke Paust