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Novel Antifungal Agent
The existing suite of clinically useful antifungals is limited. While amphotericin B and nystatin have been used widely over the past 50 years, they are associated with high toxicity and negligible oral bioavailability. Harvard researchers in the…
DBD
- Grant Zimmermann
Investigators
- Jon Clardy
Targeting fatty acid oxidation for treatment of cancer, including AML, prostate, breast and colon cancers
Several cancers are characterized by slow glycolysis and rely on non-glycolytic pathways such as fatty acid oxidation (FAO) as their main source of energy. While dependency of cancer cells on FAO has been known, the underlying mechanistic…
DBD
- Irit Ben-Chelouche
Investigators
- Marcia Haigis
3D-brain organoids: Enabling discovery through patient-derived brain organoids
The Arlotta team is developing a 3D brain organoid platform, which makes it possible to study aspects of human brain development and neurodevelopmental disorders in a format amenable to large-scale production and genetic engineering.These organoids…
DBD
- Yelena Bisharyan
Investigators
- Paola Arlotta
- Giorgia Quadrato
Functionalized and coated carbon nanotubes via atomic layer deposition
Carbon nanotubes have remarkable electrical and optical properties that have not been extensively commercialized in part due to difficulties making robust and high quality devices containing them. One current difficulty is the lack of an effective…
DBD
- Christopher Petty
Investigators
- Roy Gordon
- Damon Farmer
- Charles Marcus
- James Williams
Intracellular delivery of proteins: Aurin 1.2, an efficient non-endosomal protein delivery platform
To fully realize the therapeutic potential of proteins, exogenous proteins need to access intracellular targets. Since the vast majority of proteins cannot spontaneously cross cell membranes, a range of delivery platforms have been developed. These…
DBD
- Irit Ben-Chelouche
Investigators
- David Liu
FlicR: A bright and fast red fluorescent protein voltage indicator that reports neuronal activity
Fluorescent-protein-based voltage indicators enable imaging of the electrical activity of many genetically targeted neurons with high spatial and temporal resolution. FlicR is a new bright red fluorescent protein-based voltage indicator that has…
DBD
- Yelena Bisharyan
Investigators
- Adam Cohen
CMOS integrated NMR spectrometer
Nuclear Magnetic Resonance (NMR) spectrometers have been in use for many years and are used to provide imaging or analysis of a sample being tested. In general, an NMR spectrometer is comprised of three main components: a pulse sequencer, an NMR…
DBD
- Sam Liss
Investigators
- Donhee Ham
- Dongwan Ha
- Jeffrey Paulsen
- Song Yi-Qiao
Stretchable ionics: Layered electrolytes and dielectrics as high-speed, transparent artificial muscles
A new class of soft, stretchable materials can be utilized as a sensor or high-speed actuator. This invention incorporates a simple and low-cost design that can be made fully transparent, highly stretchable, biocompatible and biodegradable. Thus it…
DBD
- Christopher Petty
Investigators
- Zhigang Suo
- Jeong-Yun Sun
- Christoph Keplinger
- George Whitesides
Multi-axis force sensing soft artificial skin
With rapid growth in key segments such as robotics and wearable computing. Sensors are one of the critical areas of need. The soft sensor IP developed in the Wood Lab consists of stretchable sensors that register deformation and surface pressure.…
DBD
- Sam Liss
Investigators
- Robert Wood
- Daniel Vogt
- Yong Park
Modular millimeter-scale distal force sensor, based on pop-up fabrication
The ability to measure force is a critical need in small-scale systems. This invention is a low-cost force sensor that operates over a force range of 0-200 mN, with a sensitivity of 5 V/N and a resolution of 0.8 mN. Key advantages over competing…
DBD
- Sam Liss
Investigators
- Conor Walsh
- Joshua Gafford
- Robert Wood