Irit Ben-Chelouche

Director of Business Development, Harvard Medical School

Displaying: 51 - 60 of 80 Results

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PD-L1 Knock Out Mice

The signal and all of the immunoglobulin (Ig)-V-like exon of the CD274 antigen (Cd274) gene were replaced with a neomycin resistance cassette, abolishing PD-L1 gene expression. PD-L1 is one of two ligands for PD-1 and is upregulated on antigen…

Investigators

  • Arlene H. Sharpe

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R26R-Confetti Targeted Mutation Mice

Mice homozygous for the R26R-Confetti conditional allele are viable and fertile, with a CAG promoter, loxP site, and STOP cassette preventing transcription of the downstream Brainbow 2.1 sequences. The Brainbow 2.1 region contains two loxP-flanked…

Investigators

  • Jeffrey W. Lichtman

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Truncated Ab1TL Transgenic Mice

Hemizygous transgenic mice expressing only truncated class II A beta molecules lacking the 13 membrane distal residues were generated to address the role of class II cytoplasmic domains in physiological, non-transformed APC and in vivo immune…

Investigators

  • Michael J. Grusby

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NOD.DQ6, H2-Ab0null,Rag1null

Rag1 and H2-Ab1 deficient NOD mice carrying transgenes encoding humanized CD4 and HLA-DQ6 lack T and B cells and are free of autoimmune diabetes and cardiomyopathy, and do not develop thyroiditis. This model is useful in adoptive transfer…

Investigators

  • Michael J. Grusby

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Thy1-Brainbow Transgenic Mice

These Thy1-Brainbow 1.0 (line H) transgenic mice are viable and fertile. The mice possess multiple fluorescent protein sequences uniquely flanked with pairs of incompatible Lox sites alternated to create mutually exclusive recombination events;…

Investigators

  • Jeffrey W. Lichtman

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Fat3lox Targeted Mutation Mice

FAT3, an atypical cadherin protein, is expressed on amacrine cell (AC) processes in the developing and mature inner plexiform layer (IPL) of the retina and is associated with dendrite morphogenesis. These mutant mice possess loxP sites flanking exon…

Investigators

  • Lisa Goodrich

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Cx37 Knock Out Mice

The Gja4 gene encodes an intercellular channel forming protein, also known as Connexin 37, that is a component of gap junctions. These mice carry a knock out mutation of the Gja4 gene in which a PGK-NEO cassette replaces almost the entire coding…

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Ror1f/f Targeted Mutation Mice

These Ror1f/f mutant mice possess loxP sites flanking exons 3-4 of the receptor tyrosine kinase-like orphan receptor 1 (Ror1) gene. Mice that are homozygous for this allele are viable and fertile. ROR1 is a receptor for Wnt5a-mediated signaling.…

Investigators

  • Michael E Greenberg

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7B2 Knock Out Mice

While heterozygotes are viable and fertile, mice homozygous for this mutation (7B2-null) die in prepubertal or pubertal ages (5 weeks) with severe cardio-respiratory failure, convulsions, and hypothermia. No transcripts are detected in brain tissue…

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YY1lox Targeted Mutation Mice

These mice possess loxP sites on either side of exon 1 of the targeted gene. Mice that are homozygous for this allele are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. When these mutant mice are…

Investigators

  • Yang Shi

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