DBD Search
Irit Ben-Chelouche
Director of Business Development, Harvard Medical School
Displaying: 51 - 60 of 80 Results
Research Tool
Fmn2 Knock Out Mice
The proline-rich FH1 domain of the formin 2 (Fmn2) gene was disrupted with a neomycin resistance (neo) cassette, abolishing FH1 domain binding function. Formin 2, a straight-actin-filament nucleator expressed in neurons of the central nervous…
Investigators
- Philip Leder
Research Tool
Stat4 Knock Out mice
Mice homozygous for the Stat4tm1Gru mutation are viable and fertile. IL12 induced interferon-gamma secretion and stimulation of lymphocytes are defective. Development of Th1 cells in response to either IL12 or Listeria monocytogenes is also…
Investigators
- Michael J. Grusby
Research Tool
Cd1 Knock Out Mice
Mice homozygous for the Cd1tm1Gru targeted mutation are deficient in both the Cd1d1 and Cd1d2 genes (CD1.1, CD1.2). Homozygous mutant mice lack the normal natural killer cell-like T cell subset. However, type 2 T helper cell (TH2) response is…
Investigators
- Michael J. Grusby
Research Tool
CD1-deficient BXSB.Yaa Knock Out Mice
BXSB.Yaa CD1-/- (BXSB.Yaa Cd1d1/Cd1d2-/-) mice are a BXSB-congenic strain carrying a null mutation of the CD1 antigen complex; both CD1.1 (Cd1d1) and CD1.2 (Cd1d2) expression is abolished. Homozygous (CD1-/-) mice are natural killer T cell…
Investigators
- Michael J. Grusby
Research Tool
p21CIP1/WAF1 Knock Out Mice
In this knockout strain, a neo cassette replaces exon 2 of the of the cyclin-dependent kinase inhibitor 1A (Cdkn1a or p21CIP1/WAF1) gene. Homozygotes are viable, fertile, and normal in size. P21CIP1/WAF1 is expressed, in a p53-dependent manner,…
Investigators
- Philip Leder
Research Tool
Transmembrane IL-4 Knock In mice
This strain was made using gene targeting in embryonic stem cells to modify the Il4 locus by knocking-in a transmembrane domain. Expression of Il4 in a membrane-bound form provides a novel method for the identification and characterization of…
Investigators
- Michael J. Grusby
Research Tool
Hba-a1 Targeted Mutation Mice
Mice that are homozygous for the targeted mutation are viable and fertile, but are anemic. Reduced levels of gene product (mRNA) are detected by Northern blot analysis of homozygous embryos (due to compensatory expression of the _2-globin gene).…
Investigators
- Philip Leder
Research Tool
Thy1-Brainbow 1.0 Trangenic Mice
These Thy1-Brainbow 1.0 (line L) transgenic mice are viable and fertile. The mice possess multiple fluorescent protein sequences uniquely flanked with pairs of incompatible Lox sites alternated to create mutually exclusive recombination events;…
Investigators
- Jeffrey W. Lichtman
Research Tool
Cdk5lox Targeted Mutation Mice
These Cdk5 floxed mutant mice possess loxP sites flanking exons 1-5. Mice that are homozygous for this allele are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. When bred to mice that express Cre…
Investigators
- Li-Huei Tsai
Research Tool
Slamf2 Knock Out Mice
The Cd48 gene, also know as Slamf2 (signaling lymphocytic activation molecule 2), encodes for a lymphocyte cell surface antigen that binds CD2 and CD244 and is involved in regulation of T cell activation. These mice carry a targeted mutation for…
Investigators
- Arlene H. Sharpe