DBD Search
Irit Ben-Chelouche
Director of Business Development, Harvard Medical School
Displaying: 51 - 60 of 80 Results
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Truncated Ab1TL Transgenic Mice
Hemizygous transgenic mice expressing only truncated class II A beta molecules lacking the 13 membrane distal residues were generated to address the role of class II cytoplasmic domains in physiological, non-transformed APC and in vivo immune…
Investigators
- Michael J. Grusby
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NOD.DQ6, H2-Ab0null,Rag1null
Rag1 and H2-Ab1 deficient NOD mice carrying transgenes encoding humanized CD4 and HLA-DQ6 lack T and B cells and are free of autoimmune diabetes and cardiomyopathy, and do not develop thyroiditis. This model is useful in adoptive transfer…
Investigators
- Michael J. Grusby
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Thy1-Brainbow Transgenic Mice
These Thy1-Brainbow 1.0 (line H) transgenic mice are viable and fertile. The mice possess multiple fluorescent protein sequences uniquely flanked with pairs of incompatible Lox sites alternated to create mutually exclusive recombination events;…
Investigators
- Jeffrey W. Lichtman
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Fat3lox Targeted Mutation Mice
FAT3, an atypical cadherin protein, is expressed on amacrine cell (AC) processes in the developing and mature inner plexiform layer (IPL) of the retina and is associated with dendrite morphogenesis. These mutant mice possess loxP sites flanking exon…
Investigators
- Lisa Goodrich
Research Tool
Cx37 Knock Out Mice
The Gja4 gene encodes an intercellular channel forming protein, also known as Connexin 37, that is a component of gap junctions. These mice carry a knock out mutation of the Gja4 gene in which a PGK-NEO cassette replaces almost the entire coding…
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Ror1f/f Targeted Mutation Mice
These Ror1f/f mutant mice possess loxP sites flanking exons 3-4 of the receptor tyrosine kinase-like orphan receptor 1 (Ror1) gene. Mice that are homozygous for this allele are viable and fertile. ROR1 is a receptor for Wnt5a-mediated signaling.…
Investigators
- Michael E Greenberg
Research Tool
7B2 Knock Out Mice
While heterozygotes are viable and fertile, mice homozygous for this mutation (7B2-null) die in prepubertal or pubertal ages (5 weeks) with severe cardio-respiratory failure, convulsions, and hypothermia. No transcripts are detected in brain tissue…
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YY1lox Targeted Mutation Mice
These mice possess loxP sites on either side of exon 1 of the targeted gene. Mice that are homozygous for this allele are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. When these mutant mice are…
Investigators
- Yang Shi
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NOD.DQ8, H2-Ab0null Mice
The NOD transgenic HLA DQ8, H2-Ab1deficient mouse is diabetes resistant but develops cardiomyopathy resulting in early death from heart failure in both males and females. Histological exam indicates hearts are 3-4x larger than wildtype. Pathology…
Investigators
- Michael J. Grusby
Research Tool
Thy1-CFP-MitoC Transgenic Mice
These transgenic mice express Cyan Fluorescent Protein (CFP) under the control of the mouse thymus cell antigen 1, theta, Thy1, promoter. CFP is specifically localized to the mitochondria by a human cytochrome c oxidase, subunit 8A (ubiquitous),…
Investigators
- Jeffrey W. Lichtman