DBD Search
Vivian Berlin
Executive Director, HMS
Displaying: 51 - 60 of 75 Results
Research Tool
Akr1b7RFP Trangenic Mice
These transgenic mice express Red Fluorescent Protein (TagRFP-T variant) under the direction of the mouse Akr1b7, aldo-keto reductase family 1, member B7, promoter. Transgene expression is detected at high levels in the adrenal glands and…
Investigators
- Andrew P. McMahon
Research Tool
Six2-TGCtg EFGPCre Transgenic Mice
Six2-TGCtg mice harbor an ~181 kb BAC transgene with a Tet-off-eGFPCre under control of the Six2 promoter/enhancer regions within the BAC transgene. The Tet-off-eGFPCre contains both the tetracycline-controlled transactivator protein (tTA) as well…
Investigators
- Andrew P. McMahon
Research Tool
Irf8 Knock Out Mice
Mice homozygous for this Irf8 knockout allele (Irf8-/-) may be expected to to exhibit some or all of the phenotype published for other Irf8 null mutations on both a C57BL/6J-congenic and mixed genetic background. For example, other Ifr8 null mice…
Investigators
- Andrew P. McMahon
Research Tool
Wnt7a Knock Out Mice
Mice that are homozygous for the targeted mutation are viable, but sterile. A truncated mRNA transcript is detected during embryogenesis. Homozygotes exhibit ventralization of dorsal limb mesoderm tissues. The variable phenotype includes thickening…
Investigators
- Andrew P. McMahon
Research Tool
RosaGli3TFlag c/c Transgenic Mice
These RosaGli3TFlag c/c mice contain a floxed-neomycin resistance (neo) cassette and polyadenylation signal, cDNA encoding a FLAG-tagged GLI-Kruppel family member (Gli3) repressor gene, an internal ribosome entry site (IRES), and a Venus yellow…
Investigators
- Andrew P. McMahon
Research Tool
FoxD1GC Transgenic Mice
Heterozygous mice are viable and fertile, normal in size and do not display any gross physical or behavioral abnormalities. The DI states that the strain is homozygous lethal. The FoxD1GC allele expresses an eGFPCre fusion protein (EGFP and cre…
Investigators
- Andrew P. McMahon
Research Tool
Wnt-1/GAL4/cre-11 Trangenic Mice
When homozygous for both co-injected transgenes, Wnt-1/GAL4/cre-11 transgenic mice are viable and fertile. Of note for Wnt-1/GAL4/cre-11 transgenic mice on the original mixed genetic background, the donating investigator (Dr. Epstein) reported that…
Investigators
- Andrew P. McMahon
Research Tool
Osr1GCE Knock In Mice
Homozygous mice die upon birth with multiple abnormalities of the heart and urogenital system (among other tissues). Heterozygous mice are viable and fertile. The Osr1eGFPCreERt2 (Osr1GCE) "knock-in" allele both abolishes Osr1 gene function and…
Investigators
- Andrew P. McMahon
Research Tool
Pdx1-CreER Transgenic Mice
Pancreatic cells are derived from Pdx1 (pancreatic and duodenal homeobox 1)-expressing progenitors throughout embryogenesis. This conditional transgenic strain expresses Cre/Esr1 from the mouse Pdx1 promoter. Cytoplasmic stores of Cre recombinase…
Investigators
- Douglas Melton
Research Tool
B6N.Sox2-Cre Transgenic Mice
These transgenic mice express Cre recombinase under the control of the mouse SRY-box containing gene 2 promoter. The transgene integrated into an intron of Edil3 (EGF-like repeats and discoidin I-like domains 3). The insertion results in a…
Investigators
- Andrew P. McMahon