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Displaying: 151 - 160 of 270 Results
Homozygous IKKepsilon knockout mouse as an animal model for influenza virus infection
Homozygous IKKepsilon (inhibitor of kappaB kinase epsilon) mutant mice are used as animal models for influenza virus infection. Homozygous deletion results in a complete loss of the endogenous kinase function in lung, spleen, and embryonic…
DBD
- Grant Zimmermann
Investigators
- Thomas Maniatis
- Benjamin tenOever
A novel color filter array design scheme significantly reduces hardware complexity
In digital imaging applications, data are typically obtained via a spatial sub-sampling procedure implemented as a color filter array (CFA). CFA assigns a separate primary color to each pixel by placing a filter of that color over the pixel. The…
DBD
- Sam Liss
Investigators
- Patrick Wolfe
- Keigo Hirakawa
Corticospinal tract (CST)-YFP transgenic mice for monitoring axonal responses to spinal cord injury
Hemizygous transgenic mouse strain B6.Cg-Tg(Thy1-EYFP)15Jrs/J (also known as Thy-STOP-YFP) was developed by Dr. Joshua R. Sanes at Harvard University. The mouse strain harbors an Enhanced Yellow Fluorescent Protein (EYFP) controlled by mouse thymus…
DBD
- Yelena Bisharyan
Investigators
- Joshua Sanes
- Joshua Sanes
- Florence Bareyre
Protein-based therapies using quantitatively designed proteins
A bipartite, quantitatively designed protein having two discrete ligands and a linker; one ligand having the ability to strongly bind to a particular cell, the other having the ability to affect a target only when the previous ligand binds. For many…
DBD
- Grant Zimmermann
Investigators
- Pamela Silver
- Pablo Cironi
- David Miguez
Slowing down light for enhanced detection and measurement of biomolecules
The photonic crystal device is a novel method for localizing and trapping light, where the light can be utilized for a wide-variety of chemical, biological, and optical applications. Traditional chemical and biological optical sensors are limited by…
DBD
- Sam Liss
Investigators
- Frank Vollmer
- Juraj Topolancik
Robust fluorescent probes allow sensitive detection of small molecules
The invention is an efficient method to synthesize novel silver nanoparticles with bright fluorescence and a giant Raman enhancement effect. These particles, 2 – 20 nm in diameter, exhibit a highly multi-domain structure with grain sizes down to 1…
DBD
- Sam Liss
Investigators
- Xiaowei Zhuang
- Jie Zheng
Mass spectrometry-based in vitro kinome activity assay
This technology is a new generation, high-throughput assay to quantitatively assess the activity of the kinome in a variety of samples. Cocktails of synthetic peptides are combined with a sample of interest and phosphorylated by kinases in the…
DBD
- Grant Zimmermann
Investigators
- Steven Gygi
- Judit Villen
- Kazuishi Kubota
- Yong Yu
In vitro models and method of treatment for amyotrophic lateral sclerosis (ALS)
It has been impossible to isolate viable human motor neurons from patients or from postmortem samples to investigate the mechanisms leading to neural degeneration in ALS. A potential solution is to use embryonic stem cells (ESC) as a renewable…
DBD
- Vivian Berlin
Investigators
- Kevin Eggan
- Francesco Di Giorgio
Control over deposition of nanoscale materials using structured surfaces
The ability to precisely localize and control deposition of materials at the nanoscale is extremely important for a wide variety of emerging technologies. Many unique physical properties emerge only at the nanoscale and it is very useful to be able…
DBD
- Christopher Petty
Investigators
- Joanna Aizenberg
- Benjamin Hatton
Low-cost method for measuring the frequency content of a signal above the acquisition rate
Harvard researchers have developed a new method for determining the PSD of a signal that dramatically extends the effective detection bandwidth of current instruments. The invention circumvents previous limitations of acquisition rate and detector…
DBD
- Christopher Petty
Investigators
- Wesley Wong
- Kenneth Halvorsen