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A fusion intermediate state of HIV-1 gp41, targeted by broadly neutralizing antibodies, for purposes of vaccination
HIV infection generally induces a strong antibody response to the envelope glycoprotein, the sole antigen on the virion surface. Most of the induced antibodies are ineffective in preventing infection, however, as they are either non-neutralizing or…
DBD
- Grant Zimmermann
Investigators
- Stephen Harrison
- Gary Frey
- Bing Chen
Improved metal complex chemical precursors for atomic layer deposition (ALD) and chemical vapor depostion (CVD) using bicyclic guanidines
A new class of metal complex precursors has been identified for use in atomic layer deposition (ALD) and chemical vapor deposition (CVD), using bicycle guanidines as ligands as opposed to acetamidines. The ALD process involves the alternating…
DBD
- Christopher Petty
Investigators
- Roy Gordon
- Leonard Rodriguez
DBD
- Christopher Petty
Investigators
- Roy Gordon
- Hoon Kim
Using (-)-indolactam V to induce differentiation of human and mouse embryonic stem cells into pancreatic lineage
• ILV can be used alone, or in combination with growth factors, to direct differentiation of ESCs into pancreatic specification. ILV is effective on human ESC lines and mouse ESC lines. • ILV is effective on human ESC lines HUES 2, 4 and 8. After 4…
DBD
- Vivian Berlin
Investigators
- Douglas Melton
- Shuibing Chen
- Malgorzata Borowiak
- Julia Fox
- Stuart Schreiber
- Lee Peng
- Lee Rubin
- Kelvin Lam
- Lance Davidow
New cell sorting technology could replace fluorescent and magnetic technologies
Dr. Prentiss’ lab has developed a new cell sorting technology based on microfluidics. This technique enables manipulation of non-magnetic micro- and nano-entities, including cells, immersed in magnetic fluids. Compared to existing MACS and FACS cell…
DBD
- Sam Liss
Investigators
- Mara Prentiss
- Pierre Striehl
- Howard Stone
- Efraim Feinstein
Robust thin film solid oxide fuel cell
Among the major fuel cell chemistries, Solid Oxide Fuel Cells (SOFCs) are considered most desirable due to their high energy conversion efficiency, fuel flexibility, and contaminant tolerance. Conventional solid oxide fuel cells operate at 800°C -…
DBD
- Sam Liss
Investigators
- Shriram Ramanathan
- Alexander Johnson
Vertical silicon nanowires as a universal platform for highly efficient delivery of bioactive molecules into living cells
This platform consists of an array of surface-modified vertical silicon nanowires that have been chemically grown or etched on a wafer and to which virtually any kind of bioactive species (drug, protein, nucleic acid, nanoparticles) may be attached…
DBD
- Christopher Petty
Investigators
- Hongkun Park
- EunGyeong Yang
- JinSeok Lee
- Alexander Shalek
- Myung-Han Yoon
- Jacob Robinson
- Amy Sutton
- Marsela Jorgolli
Paper-supported 3D cell culture for cell and tissue-based bioassays
In this new approach, cells are cultured in 3D on a paper scaffold by adding a hydrogel precursor, as a fluid containing suspended cells, to a paper support, allowing the cell-containing fluid to distribute through the paper by capillary wicking,…
DBD
- Christopher Petty
Investigators
- George Whitesides
- Ratmir Derda
- Anna Laromaine Sague
Novel methods for generating regulatory T-cells
Regulatory T-cells (Tregs) are key mediators of peripheral tolerance that can actively suppress effector T-cells, inhibit inflammation and mediate self-tolerance. Unlike naturally occurring Tregs (nTregs) which develop in the thymus,…
DBD
- Irit Ben-Chelouche
Investigators
- Arlene Sharpe
- Loise Francisco
- Vijay Kuchroo
A system for the continuous directed evolution of biomolecules
Researchers in the laboratory of Professor David Liu have developed a platform that enables the continuous directed evolution of gene-encoded molecules that can be linked to protein production in E. coli. During phage-assisted continuous evolution…
DBD
- Irit Ben-Chelouche
Investigators
- David Liu
- Kevin Esvelt
- Jacob Carlson
- Ahmed Badran