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Inhibiting Microbial Metabolism of Levodopa to Increase Availability in the CNS
Parkinson’s disease (PD) impacts 10 million people globally, with 60,000 Americans newly diagnosed every year. Levodopa remains the gold standard treatment for PD, despite limitations including side effects and peripheral metabolism. Current…
DBD
- Yelena Bisharyan
Investigators
- Emily Balskus
New Raman Microscopy Technique Accelerates Digital Pathology
Current methods for pathological diagnosis of diseases require laborious and costly sample processing steps and provide inherently qualitative information. Moreover, batch to batch variations in staining intensity results in highly variable images,…
DBD
- Irit Ben-Chelouche
Investigators
- Marc Kirschner
- Seungeun Oh
Novel Biochemical and Computational Approaches to Increase Mass Spectrometry Sensitivity
Mass spectrometry (MS) has become the leading protein identification technique. Current mass spectrometry methods rely on tandem MS/MS detection, where a prepared peptide digestion sample is injected into the mass spectrometer and analyzed by its…
DBD
- Irit Ben-Chelouche
Investigators
- Marc Kirschner
- Mingjie Dai
Nanophotonic quantum memory for quantum key distribution
Quantum networks have the potential to unlock significant advancements in secure communications. Such networks require nodes which perform quantum processing on a small register of interconnected qubits with long coherence times. Harvard researchers…
Investigators
- Mikhail Lukin
- Marko Loncar
- Denis Sukachev
- Christian Nguyen
- Bartholomeus Machielse
- David Levonian
- Ralf Riedinger
- Mihir Bhaskar
Continuous Evolution (PACE) of Botulinum Neurotoxins with Reprogrammed Substrate Specificity for Intracellular Protease Therapy
Biomacromolecule-based therapies are of keen interest to the pharmaceutical industry because macromolecules engage in highly specific interactions in biological systems compared to traditional small molecules. Despite their success, macromolecular…
DBD
- Irit Ben-Chelouche
Investigators
- David Liu
Wearables to Monitor Strength Training
The ability to track and monitor one’s own exercise routine is fundamental to assessing overall fitness and supporting a healthy lifestyle. While conventional fitness wearables typically capture metrics relating to cardio output, researchers in the…
DBD
- Sam Liss
Investigators
- Conor Walsh
Preventing Stress-Induced Greying of Hair
Loss of hair pigmentation has long been associated with stress; however, stress-related changes at the level of the somatic cell have only recently been elucidated. The hair follicle consists of two stem cell populations: epithelial-derived hair…
DBD
- Yelena Bisharyan
Investigators
- Ya-Chieh Hsu
- Bing Zhang
Direct processing of saltwater for renewable energy storage
Technological advances have created an abundance of renewable energy sources (wind and solar), however, storing energy at scale is an essential part of transitioning to renewables and remains a critical challenge. The Nocera lab has developed a…
DBD
- Christopher Petty
Investigators
- Daniel Nocera
- Samuel Veroneau
Biomimetic heart valve replacement
Researchers from the Disease Biology Group at Harvard have developed tissue-engineered replacement heart valves with a composition, multiscale architecture, and mechanical properties that mimic native valves. The researchers utilize a novel “jet…
Investigators
- Kevin Parker
Sunlight-induced catalysis for biofuel and electricity generation
A new graphene-based material architecture for facilitating catalysis has been developed in the lab of Professor Lene Hau. The hybrid biological and nano-engineered structure acts as an artificial cell-membrane to control electron and proton…
Investigators
- Lene Hau