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Displaying: 31 - 40 of 103 Results
Immunology and Computational Biology Partnership
Professors Diane Mathis and Christophe Benoist at Harvard Medical School, together with other world-renowned immunologists and computational biologists from multiple research institutions, have created the Immunological Genome Project – Immgen…
DBD
- Irit Ben-Chelouche
Investigators
- Diane Mathis
- Christophe Benoist
Cell-based assay for the discovery of glycogen synthase kinase inhibitors
This cell-based assay is applicable to diverse biological systems for discovery of glycogen synthase kinase inhibitors. The inhibition of GSK-3b has dramatic morphogenic effects during the early development of numerous organisms, including humans,…
DBD
- Vivian Berlin
Investigators
- Douglas Melton
- Peter Klein
Production and uses of polymerase colony ("polony") arrays
The invention provides methods for rapid fabrication and use of replicable, high-density nucleic acid arrays. Array features are produced through amplification on a support matrix of nucleic acid templates of interest. A significant advance over…
DBD
- Maryanne Fenerjian
Investigators
- George Church
- Robi Mitra
Surface-bound double-stranded DNA protein arrays
Developed at Harvard Medical School, this invention provides nucleic acid arrays specifically designed for the assay of DNA-dependent protein:protein binding and/or physical interactions between proteins and nucleic acid molecules. Intermolecular…
DBD
- Maryanne Fenerjian
Investigators
- George Church
- Martha Bulyk
AlignAce motif searching software
Developed by genomics researchers at Harvard Medical School, AlignAce employs an algorithm that scans non-coding nucleic acid sequences at high resolution for motifs that occur with non-random frequency. This algorithm is built into a multi-level…
DBD
- Maryanne Fenerjian
Investigators
- George Church
- Jason Hughes
- Frederick Roth
Migration inhibitory factor (MIF) knockout mouse
To study the biological role of migration inhibitory factor (MIF), a pleiotropic cytokine, we generated a mouse strain lacking MIF by gene targeting in embryonic stem cells. Analysis of the role of MIF during sepsis showed that MIF-/- mice were…
DBD
- Grant Zimmermann
Investigators
- John David
- Marcelo Bozza
- Craig Gerard
Ultra fast method for chiral catalyst discovery
This invention is a novel method for determining--in less than 24 hours--enantiomeric ratios, percent conversions, and absolute configurations of all members of a chemical library containing at least 10,000 reaction products. Reaction mixtures are…
DBD
- Vivian Berlin
Investigators
- Matthew Shair
- Gregory Korbel
- Gojko Lilac
Time and concentration warping software for RNA and protein expression data
The predominant strategies for drug discovery today employ high-throughput screens and microarray-based methods that generate large data sets. Increasingly, these techniques are being used to study biological processes as a function of time and/or…
DBD
- Maryanne Fenerjian
Investigators
- George Church
- John Aach
A drug discovery platform using novel labeled uridine analogs contribute to molecular biology research
This invention consists of novel 5-amino deoxyribouridine analogs. The analogs are labeled with a radioactive or fluorescent moiety and incorporated into nucleic acid by PCR for use in genomic research applications. One assay design involves a…
DBD
- Vivian Berlin
Investigators
- Gregory Verdine
- Michael Storek
anti-MARCO monoclonal antibody
The monoclonal antibody recognizes the Macrophage Receptor with Collagenous structure (MARCO). The scavenger receptors (SRs) expressed by macrophages are thought to play an important role in the immune response against bacteria by mediating binding…
DBD
- Grant Zimmermann
Investigators
- Lester Kobzik
- Aiyappa Palecanda